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Murcko scaffold

Ring system with 3 rings and 17 atoms

49 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 17
Chemicals: 49
With full pages: 5

Scaffold SMILES

O=C(Nc1cc2c(s1)CCCC2)c1cc[nH]n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1cc2c(s1)CCCC2)c1cc[nH]n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

2-[[(4-Chloro-1-methyl-3-pyrazolyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester chemical structure, C15H16ClN3O3S, CAS 328251-69-0

2-[[(4-Chloro-1-methyl-3-pyrazolyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester

CAS 328251-69-0C₁₅H₁₆ClN₃O₃S

Ethyl 2-(1-methyl-1H-pyrazole-5-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C16H19N3O3S, CAS 296263-72-4

Ethyl 2-(1-methyl-1H-pyrazole-5-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

CAS 296263-72-4C₁₆H₁₉N₃O₃S

Methyl 2-{[(1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H19N3O3S, CAS 512807-25-9

Methyl 2-{[(1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 512807-25-9C₁₆H₁₉N₃O₃S

Ethyl 2-[[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C17H21N3O3S, CAS 514799-11-2

Ethyl 2-[[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

CAS 514799-11-2C₁₇H₂₁N₃O₃S

Ethyl 2-[(2-ethyl-4-nitropyrazole-3-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H20N4O5S, CAS 514799-19-0

Ethyl 2-[(2-ethyl-4-nitropyrazole-3-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 514799-19-0C₁₇H₂₀N₄O₅S

Ethyl 2-{[(1-methyl-4-nitro-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H18N4O5S, CAS 294194-41-5

Ethyl 2-{[(1-methyl-4-nitro-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 294194-41-5C₁₆H₁₈N₄O₅S

Isopropyl 2-(1-methyl-4-nitro-1H-pyrazole-3-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C17H20N4O5S, CAS 360573-22-4

Isopropyl 2-(1-methyl-4-nitro-1H-pyrazole-3-carboxamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

CAS 360573-22-4C₁₇H₂₀N₄O₅S

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methylpyrazole-3-carboxamide chemical structure, C14H14N4OS, CAS 489408-01-7

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methylpyrazole-3-carboxamide

CAS 489408-01-7C₁₄H₁₄N₄OS

Ethyl 2-[(1-methyl-4-nitropyrazole-3-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C16H18N4O5S, CAS 351333-01-2

Ethyl 2-[(1-methyl-4-nitropyrazole-3-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 351333-01-2C₁₆H₁₈N₄O₅S

Isopropyl 2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H21N3O3S, CAS 492427-50-6

Isopropyl 2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 492427-50-6C₁₇H₂₁N₃O₃S

Ethyl 5-[(3-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-2-methylpyrazole-3-carboxylate chemical structure, C18H21N3O5S, CAS 494791-27-4

Ethyl 5-[(3-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-2-methylpyrazole-3-carboxylate

CAS 494791-27-4C₁₈H₂₁N₃O₅S

4-Bromo-N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-ethylpyrazole-3-carboxamide chemical structure, C15H17BrN4O2S, CAS 492427-32-4

4-Bromo-N-(3-carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-ethylpyrazole-3-carboxamide

CAS 492427-32-4C₁₅H₁₇BrN₄O₂S

2-Methoxyethyl 2-{[(4-chloro-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H20ClN3O4S, CAS 491828-98-9

2-Methoxyethyl 2-{[(4-chloro-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 491828-98-9C₁₇H₂₀ClN₃O₄S

Ethyl 1-methyl-5-[(3-propoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]pyrazole-3-carboxylate chemical structure, C20H25N3O5S, CAS 512808-89-8

Ethyl 1-methyl-5-[(3-propoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]pyrazole-3-carboxylate

CAS 512808-89-8C₂₀H₂₅N₃O₅S

Ethyl 5-[(3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate chemical structure, C19H23N3O5S, CAS 957294-60-9

Ethyl 5-[(3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate

CAS 957294-60-9C₁₉H₂₃N₃O₅S

Ethyl 2-{[(1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H21N3O3S, CAS 514799-92-9

Ethyl 2-{[(1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 514799-92-9C₁₇H₂₁N₃O₃S

Ethyl 2-{[(4-bromo-1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H20BrN3O3S, CAS 351333-00-1

Ethyl 2-{[(4-bromo-1-methyl-1H-pyrazol-3-yl)carbonyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 351333-00-1C₁₇H₂₀BrN₃O₃S

Ethyl 6-ethyl-2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H23N3O3S, CAS 492427-65-3

Ethyl 6-ethyl-2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 492427-65-3C₁₈H₂₃N₃O₃S

N-(3-Carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methyl-3-pyrazolecarboxamide chemical structure, C14H16N4O2S, CAS 488821-87-0

N-(3-Carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-methyl-3-pyrazolecarboxamide

CAS 488821-87-0C₁₄H₁₆N₄O₂S

Ethyl 5-[(3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-2-methylpyrazole-3-carboxylate chemical structure, C19H23N3O5S, CAS 494791-25-2

Ethyl 5-[(3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-2-methylpyrazole-3-carboxylate

CAS 494791-25-2C₁₉H₂₃N₃O₅S

Isopropyl 2-{[(1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H23N3O3S, CAS 492425-58-8

Isopropyl 2-{[(1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 492425-58-8C₁₈H₂₃N₃O₃S

Ethyl 5-[(3-butan-2-yloxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate chemical structure, C21H27N3O5S, CAS 496834-91-4

Ethyl 5-[(3-butan-2-yloxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)carbamoyl]-1-methylpyrazole-3-carboxylate

CAS 496834-91-4C₂₁H₂₇N₃O₅S

N-(3-Carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-methyl-4-nitropyrazole-3-carboxamide chemical structure, C14H15N5O4S, CAS 515847-13-9

N-(3-Carbamoyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-methyl-4-nitropyrazole-3-carboxamide

CAS 515847-13-9C₁₄H₁₅N₅O₄S

Propyl 2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C17H21N3O3S, CAS 492427-64-2

Propyl 2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

CAS 492427-64-2C₁₇H₂₁N₃O₃S