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Murcko scaffold

Ring system with 3 rings and 16 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
8
With full pages
5
Scaffold SMILES

C(=Cc1cccs1)c1nc2ccccc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1cccs1)c1nc2ccccc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

(2E)-2-(1H-1,3-Benzodiazol-2-yl)-3-(thiophen-2-yl)prop-2-enenitrile chemical structure, C14H9N3S, CAS 104030-31-1
(2E)-2-(1H-1,3-Benzodiazol-2-yl)-3-(thiophen-2-yl)prop-2-enenitrile
CAS 104030-31-1C14H9N3S
(E)-2-(1-Methyl-1H-benzo[d]imidazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylonitrile chemical structure, C15H10N4O2S, CAS 328027-85-6
(E)-2-(1-Methyl-1H-benzo[d]imidazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylonitrile
CAS 328027-85-6C15H10N4O2S
(E)-3-(5-Bromothiophen-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile chemical structure, C15H10BrN3OS, CAS 476279-78-4
(E)-3-(5-Bromothiophen-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile
CAS 476279-78-4C15H10BrN3OS
2-(1H-Benzo[d]imidazol-2(3H)-ylidene)-3-(5-bromothiophen-2-yl)-3-oxopropanenitrile chemical structure, C14H8BrN3OS, CAS 391228-73-2
2-(1H-Benzo[d]imidazol-2(3H)-ylidene)-3-(5-bromothiophen-2-yl)-3-oxopropanenitrile
CAS 391228-73-2C14H8BrN3OS
(E)-3-(5-Chlorothiophen-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile chemical structure, C15H10ClN3OS, CAS 476279-77-3
(E)-3-(5-Chlorothiophen-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile
CAS 476279-77-3C15H10ClN3OS
(2Z)-2-(1H-Benzimidazol-2-yl)-3-hydroxy-3-(thiophen-2-yl)prop-2-enenitrile chemical structure, C14H9N3OS, CAS 476211-13-9
(2Z)-2-(1H-Benzimidazol-2-yl)-3-hydroxy-3-(thiophen-2-yl)prop-2-enenitrile
CAS 476211-13-9C14H9N3OS
(E)-2-(1-Methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-(5-nitrothiophen-2-yl)-3-oxopropanenitrile chemical structure, C15H10N4O3S, CAS 307327-01-1
(E)-2-(1-Methyl-1H-benzo[d]imidazol-2(3H)-ylidene)-3-(5-nitrothiophen-2-yl)-3-oxopropanenitrile
CAS 307327-01-1C15H10N4O3S
2-(1-Methyl(3-hydrobenzimidazol-2-ylidene))-3-(5-nitro(2-thienyl))-3-oxopropan enitrile chemical structure, C15H10N4O3S
2-(1-Methyl(3-hydrobenzimidazol-2-ylidene))-3-(5-nitro(2-thienyl))-3-oxopropan enitrile
C15H10N4O3S