Murcko scaffold
(1-Benzylpiperidin-3-yl)-piperidin-1-ylmethanone scaffold
50 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 21
- Chemicals
- 50
- With full pages
- 4
Scaffold SMILES
O=C(C1CCCN(Cc2ccccc2)C1)N1CCCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 50 chemicals
![[1-[(2,4-Dimethoxyphenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone chemical structure, C20H30N2O3, CAS 524058-93-3](/s/FFOXUMWZCBRROC-UHFFFAOYSA-N.svg)
[1-[(2,4-Dimethoxyphenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone
CAS 524058-93-3C20H30N2O3
1-(4-Methylbenzyl)-3-(1-piperidinylcarbonyl)piperidine
CAS 524059-69-6C19H28N2O
(1-Benzylpiperidin-3-yl)-piperidin-1-ylmethanone
CAS 524058-58-0C18H26N2O
![[1-[(4-Ethylphenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone chemical structure, C20H30N2O, CAS 524059-12-9](/s/ZIMVRNMKAUSOED-UHFFFAOYSA-N.svg)
[1-[(4-Ethylphenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone
CAS 524059-12-9C20H30N2O
![[1-[(3-Bromophenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone chemical structure, C18H25BrN2O, CAS 524058-69-3](/s/DALTVDLZVWJFER-UHFFFAOYSA-N.svg)
[1-[(3-Bromophenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone
CAS 524058-69-3C18H25BrN2O
![Piperidin-1-yl-[1-[(3,4,5-trimethoxyphenyl)methyl]piperidin-3-yl]methanone chemical structure, C21H32N2O4, CAS 524059-83-4](/s/RZYNIPPEJBIZJE-UHFFFAOYSA-N.svg)
Piperidin-1-yl-[1-[(3,4,5-trimethoxyphenyl)methyl]piperidin-3-yl]methanone
CAS 524059-83-4C21H32N2O4
![Piperidin-1-yl-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-3-yl]methanone chemical structure, C19H25F3N2O, CAS 524059-73-2](/s/PSWQTCPQIOCSJM-UHFFFAOYSA-N.svg)
Piperidin-1-yl-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-3-yl]methanone
CAS 524059-73-2C19H25F3N2O
![[1-[(2-Ethoxyphenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone chemical structure, C20H30N2O2, CAS 524059-05-0](/s/WZNXWRUGVYPQAF-UHFFFAOYSA-N.svg)
[1-[(2-Ethoxyphenyl)methyl]piperidin-3-yl]-piperidin-1-ylmethanone
CAS 524059-05-0C20H30N2O2
(1-(5-Bromo-2-methoxybenzyl)piperidin-3-yl)(piperidin-1-yl)methanone
CAS 524058-63-7C19H27BrN2O2
![1-[(2,5-Difluorophenyl)methyl]-3-(piperidine-1-carbonyl)piperidine chemical structure, C18H24F2N2O, CAS 2775941-38-1](/s/PWYXIJDJTXNTIO-UHFFFAOYSA-N.svg)
1-[(2,5-Difluorophenyl)methyl]-3-(piperidine-1-carbonyl)piperidine
CAS 2775941-38-1C18H24F2N2O
![3-(Piperidine-1-carbonyl)-1-{[3-(trifluoromethyl)phenyl]methyl}piperidine chemical structure, C19H25F3N2O, CAS 2781528-99-0](/s/XVPJISQZJTUDKQ-UHFFFAOYSA-N.svg)
3-(Piperidine-1-carbonyl)-1-{[3-(trifluoromethyl)phenyl]methyl}piperidine
CAS 2781528-99-0C19H25F3N2O
![1-[(3-Fluoro-4-methoxyphenyl)methyl]-3-(piperidine-1-carbonyl)piperidine chemical structure, C19H27FN2O2, CAS 2772661-78-4](/s/ZGGMUDKZRLSYOH-UHFFFAOYSA-N.svg)
1-[(3-Fluoro-4-methoxyphenyl)methyl]-3-(piperidine-1-carbonyl)piperidine
CAS 2772661-78-4C19H27FN2O2
![3-{[3-(Piperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile chemical structure, C19H25N3O, CAS 2791831-17-7](/s/CYYABONUFASGQL-UHFFFAOYSA-N.svg)
3-{[3-(Piperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile
CAS 2791831-17-7C19H25N3O
![3-Fluoro-4-{[3-(piperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile chemical structure, C19H24FN3O, CAS 2877720-92-6](/s/NEAZAOHXWAUHHT-UHFFFAOYSA-N.svg)
3-Fluoro-4-{[3-(piperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile
CAS 2877720-92-6C19H24FN3O
![4-{[3-(Piperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile chemical structure, C19H25N3O, CAS 2785509-93-3](/s/ICPWJRRMMCWKMI-UHFFFAOYSA-N.svg)
4-{[3-(Piperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile
CAS 2785509-93-3C19H25N3O
![4,4-Difluoro-1-{1-[(4-fluorophenyl)methyl]piperidine-3-carbonyl}piperidine chemical structure, C18H23F3N2O, CAS 2770585-48-1](/s/PGHWAQNISOYOCB-UHFFFAOYSA-N.svg)
4,4-Difluoro-1-{1-[(4-fluorophenyl)methyl]piperidine-3-carbonyl}piperidine
CAS 2770585-48-1C18H23F3N2O
![4,4-Difluoro-1-[1-(1-phenylethyl)piperidine-3-carbonyl]piperidine chemical structure, C19H26F2N2O, CAS 2770641-67-1](/s/YTRFJHKQGWBNGL-UHFFFAOYSA-N.svg)
4,4-Difluoro-1-[1-(1-phenylethyl)piperidine-3-carbonyl]piperidine
CAS 2770641-67-1C19H26F2N2O
![1-{1-[(2,5-Difluorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine chemical structure, C18H22F4N2O, CAS 2770587-36-3](/s/UNGQJHOYFKENGB-UHFFFAOYSA-N.svg)
1-{1-[(2,5-Difluorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine
CAS 2770587-36-3C18H22F4N2O
![4,4-Difluoro-1-{1-[(2-methylphenyl)methyl]piperidine-3-carbonyl}piperidine chemical structure, C19H26F2N2O, CAS 2770588-59-3](/s/CQAZHILRCRDFCG-UHFFFAOYSA-N.svg)
4,4-Difluoro-1-{1-[(2-methylphenyl)methyl]piperidine-3-carbonyl}piperidine
CAS 2770588-59-3C19H26F2N2O
![1-{1-[(4-Chlorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine chemical structure, C18H23ClF2N2O, CAS 2770636-81-0](/s/WDTRDGMXLFNVRK-UHFFFAOYSA-N.svg)
1-{1-[(4-Chlorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine
CAS 2770636-81-0C18H23ClF2N2O
![1-{1-[(2,5-Dimethylphenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine chemical structure, C20H28F2N2O, CAS 2770591-55-2](/s/ISEDLQIVCAXDDK-UHFFFAOYSA-N.svg)
1-{1-[(2,5-Dimethylphenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine
CAS 2770591-55-2C20H28F2N2O
![4,4-Difluoro-1-(1-{[3-(trifluoromethyl)phenyl]methyl}piperidine-3-carbonyl)piperidine chemical structure, C19H23F5N2O, CAS 2770634-13-2](/s/PICSXUXRWNCODA-UHFFFAOYSA-N.svg)
4,4-Difluoro-1-(1-{[3-(trifluoromethyl)phenyl]methyl}piperidine-3-carbonyl)piperidine
CAS 2770634-13-2C19H23F5N2O
![1-{1-[(4-Bromophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine chemical structure, C18H23BrF2N2O, CAS 2770603-98-8](/s/RHCWNEOHPAMMHV-UHFFFAOYSA-N.svg)
1-{1-[(4-Bromophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine
CAS 2770603-98-8C18H23BrF2N2O
![1-{1-[(3-Bromophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine chemical structure, C18H23BrF2N2O, CAS 2770582-86-8](/s/CLCIEEFHHSHIFK-UHFFFAOYSA-N.svg)
1-{1-[(3-Bromophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine
CAS 2770582-86-8C18H23BrF2N2O
- 1-(1-Benzylpiperidine-3-carbonyl)-4,4-difluoropiperidine2770604-10-7C18H24F2N2O
- 4,4-Difluoro-1-{1-[(3-fluoro-4-methoxyphenyl)methyl]piperidine-3-carbonyl}piperidine2770622-15-4C19H25F3N2O2
- 1-{1-[(2,4-Difluorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770614-46-3C18H22F4N2O
- 3-{[3-(4,4-Difluoropiperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile2770630-99-2C19H23F2N3O
- 4-{[3-(4,4-Difluoropiperidine-1-carbonyl)piperidin-1-yl]methyl}benzonitrile2770609-95-3C19H23F2N3O
- 4-{[3-(4,4-Difluoropiperidine-1-carbonyl)piperidin-1-yl]methyl}-3-fluorobenzonitrile2770641-25-1C19H22F3N3O
- 4,4-Difluoro-1-{1-[(4-methoxyphenyl)methyl]piperidine-3-carbonyl}piperidine2770621-65-1C19H26F2N2O2
- 4,4-Difluoro-1-{1-[(3-methoxyphenyl)methyl]piperidine-3-carbonyl}piperidine2770640-43-0C19H26F2N2O2
- 4,4-Difluoro-1-{1-[(2-fluorophenyl)methyl]piperidine-3-carbonyl}piperidine2770594-23-3C18H23F3N2O
- (4,4-Difluoropiperidin-1-yl)-[1-[(3-fluorophenyl)methyl]piperidin-3-yl]methanon2770622-86-9C18H23F3N2O
- 1-{1-[(3,5-Difluorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770582-69-7C18H22F4N2O
- 4,4-Difluoro-1-{1-[(4-methylphenyl)methyl]piperidine-3-carbonyl}piperidine2770605-26-8C19H26F2N2O
- 4,4-Difluoro-1-{1-[(3-methylphenyl)methyl]piperidine-3-carbonyl}piperidine2770622-57-4C19H26F2N2O
- 1-{1-[(3,5-Dimethoxyphenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770608-67-6C20H28F2N2O3
- 1-{1-[(2-Chlorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770612-57-0C18H23ClF2N2O
- 1-{1-[(2-Chloro-6-fluorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770639-12-6C18H22ClF3N2O
- 4,4-Difluoro-1-(1-{[4-(trifluoromethyl)phenyl]methyl}piperidine-3-carbonyl)piperidine2770609-64-6C19H23F5N2O
- 4,4-Difluoro-1-(1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-3-carbonyl)piperidine2770587-31-8C19H23F5N2O
- 4,4-Difluoro-1-(1-{[4-(trifluoromethoxy)phenyl]methyl}piperidine-3-carbonyl)piperidine2770600-28-5C19H23F5N2O2
- 1-{1-[(2-Bromophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770642-25-4C18H23BrF2N2O
- 1-{1-[(3,4-Dichlorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770639-57-9C18H22Cl2F2N2O
- 1-{1-[(2,4-Dichlorophenyl)methyl]piperidine-3-carbonyl}-4,4-difluoropiperidine2770616-60-7C18H22Cl2F2N2O
- 1-[(2,4-Difluorophenyl)methyl]-3-(piperidine-1-carbonyl)piperidine2775977-52-9C18H24F2N2O
- 1-[(3,5-Dimethoxyphenyl)methyl]-3-(piperidine-1-carbonyl)piperidine2787385-64-0C20H30N2O3
Related scaffolds
Same ring framework with different atoms or bond orders
C1CCC(OC2CCCC(OC3CCCCO3)C2)OC148 chemicals
O=C1C(=Cc2ccccc2)CCCC1=Cc1ccccc119 chemicals
c1ccc(Nc2ccnc(Nc3ccccc3)n2)cc117 chemicals
c1ccc(Cc2cccc(Cc3ccccc3)c2)cc116 chemicals
c1ccc(Nc2ncnc(CN3CCCCC3)n2)cc115 chemicals
O=C1C(=Cc2ccccc2)CNCC1=Cc1ccccc113 chemicals
C1CCC(OC2CCOC(OC3CCCOC3)C2)OC111 chemicals
c1ccc(Nc2ncnc(Nc3ccccc3)n2)cc111 chemicals
c1ccc(Nc2ncnc(CN3CCNCC3)n2)cc110 chemicals
C1CCC(OC2CCOC(OC3CCOCC3)C2)OC19 chemicals
c1ccc(Oc2cccc(Oc3ccccc3)c2)cc18 chemicals
O=C(C1CCCN(S(=O)(=O)c2ccccc2)C1)N1CCNCC17 chemicals