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Murcko scaffold

3,5-Bis(benzylidene)-4-piperidone scaffold

73 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
73
With full pages
13
Scaffold SMILES

O=C1C(=Cc2ccccc2)CNCC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,5-Bis(benzylidene)-4-piperidone page
Murcko scaffold O=C1C(=Cc2ccccc2)CNCC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 73 chemicals

3,5-Bis(benzylidene)-1-methyl-4-piperidone chemical structure, C20H19NO
3,5-Bis(benzylidene)-1-methyl-4-piperidone
C20H19NO
4-Piperidinone, 3,5-bis(phenylmethylene)-, hydrochloride chemical structure, C19H18ClNO, CAS 54237-35-3
4-Piperidinone, 3,5-bis(phenylmethylene)-, hydrochloride
CAS 54237-35-3C19H18ClNO
3,5-Bis(benzylidene)-4-piperidone chemical structure, C19H17NO, CAS 132766-61-1
3,5-Bis(benzylidene)-4-piperidone
CAS 132766-61-1C19H17NO
4-Piperidinone, 1-methyl-3,5-bis(phenylmethylene)-, hydrochloride chemical structure, C20H20ClNO, CAS 54237-25-1
4-Piperidinone, 1-methyl-3,5-bis(phenylmethylene)-, hydrochloride
CAS 54237-25-1C20H20ClNO
3,5-Bis[(4-nitrophenyl)methylidene]piperidin-4-one chemical structure, C19H15N3O5, CAS 330450-41-4
3,5-Bis[(4-nitrophenyl)methylidene]piperidin-4-one
CAS 330450-41-4C19H15N3O5
3,5-Bis[[4-(dimethylamino)phenyl]methylidene]-1-prop-2-enoylpiperidin-4-one chemical structure, C26H29N3O2, CAS 330450-47-0
3,5-Bis[[4-(dimethylamino)phenyl]methylidene]-1-prop-2-enoylpiperidin-4-one
CAS 330450-47-0C26H29N3O2
1-Ethyl-3,5-bis(phenylmethylene)-4-piperidinone chemical structure, C21H21NO, CAS 7069-88-7
1-Ethyl-3,5-bis(phenylmethylene)-4-piperidinone
CAS 7069-88-7C21H21NO
(3E,5E)-1-Methyl-3,5-bis[(3-nitrophenyl)methylidene]piperidin-4-one chemical structure, C20H17N3O5, CAS 920030-44-0
(3E,5E)-1-Methyl-3,5-bis[(3-nitrophenyl)methylidene]piperidin-4-one
CAS 920030-44-0C20H17N3O5
(3Z,5E)-3,5-Bis(3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one chemical structure, C24H27NO5, CAS 315691-89-5
(3Z,5E)-3,5-Bis(3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one
CAS 315691-89-5C24H27NO5
(3E,5E)-3,5-Bis[(2,4-dimethylphenyl)methylidene]-1-methylpiperidin-4-one chemical structure, C24H27NO, CAS 330657-24-4
(3E,5E)-3,5-Bis[(2,4-dimethylphenyl)methylidene]-1-methylpiperidin-4-one
CAS 330657-24-4C24H27NO
(3E,5E)-3,5-Bis[(4-tert-butylphenyl)methylidene]-1-methylpiperidin-4-one chemical structure, C28H35NO, CAS 380626-07-3
(3E,5E)-3,5-Bis[(4-tert-butylphenyl)methylidene]-1-methylpiperidin-4-one
CAS 380626-07-3C28H35NO
(3E,5E)-1-Methyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylidene]piperidin-4-one chemical structure, C26H31NO7, CAS 1049971-16-5
(3E,5E)-1-Methyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylidene]piperidin-4-one
CAS 1049971-16-5C26H31NO7
(3E,5E)-3,5-Bis[(4-fluorophenyl)methylidene]-1-propylpiperidin-4-one chemical structure, C22H21F2NO, CAS 331839-29-3
(3E,5E)-3,5-Bis[(4-fluorophenyl)methylidene]-1-propylpiperidin-4-one
CAS 331839-29-3C22H21F2NO
(3E,5E)-3,5-Dibenzylidene-1-propylpiperidin-4-one chemical structure, C22H23NO, CAS 296798-88-4
(3E,5E)-3,5-Dibenzylidene-1-propylpiperidin-4-one
CAS 296798-88-4C22H23NO
(3Z,5E)-3,5-Bis[(4-fluorophenyl)methylidene]-1-methylpiperidin-4-one chemical structure, C20H17F2NO, CAS 4369-13-5
(3Z,5E)-3,5-Bis[(4-fluorophenyl)methylidene]-1-methylpiperidin-4-one
CAS 4369-13-5C20H17F2NO
(3E,5E)-3,5-Bis[(4-fluorophenyl)methylidene]-1-methylpiperidin-4-one chemical structure, C20H17F2NO, CAS 920030-35-9
(3E,5E)-3,5-Bis[(4-fluorophenyl)methylidene]-1-methylpiperidin-4-one
CAS 920030-35-9C20H17F2NO
(3E,5E)-3,5-Bis[(4-nitrophenyl)methylidene]-1-propylpiperidin-4-one chemical structure, C22H21N3O5, CAS 5154-94-9
(3E,5E)-3,5-Bis[(4-nitrophenyl)methylidene]-1-propylpiperidin-4-one
CAS 5154-94-9C22H21N3O5
3,5-Bis[(4-bromophenyl)methylidene]-1-propylpiperidin-4-one chemical structure, C22H21Br2NO, CAS 412957-50-7
3,5-Bis[(4-bromophenyl)methylidene]-1-propylpiperidin-4-one
CAS 412957-50-7C22H21Br2NO
(3E,5E)-1-Methyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one chemical structure, C26H31NO7, CAS 1195795-93-7
(3E,5E)-1-Methyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one
CAS 1195795-93-7C26H31NO7
(3Z,5E)-3,5-Bis[(4-bromophenyl)methylidene]-1-ethylpiperidin-4-one chemical structure, C21H19Br2NO, CAS 330657-32-4
(3Z,5E)-3,5-Bis[(4-bromophenyl)methylidene]-1-ethylpiperidin-4-one
CAS 330657-32-4C21H19Br2NO
4-Piperidinone, 3,5-bis[(4-hydroxyphenyl)methylene]-1-methyl- chemical structure, C20H19NO3, CAS 142808-53-5
4-Piperidinone, 3,5-bis[(4-hydroxyphenyl)methylene]-1-methyl-
CAS 142808-53-5C20H19NO3
3,5-Bis[(3-bromophenyl)methylidene]-1-methylpiperidin-4-one chemical structure, C20H17Br2NO, CAS 721414-89-7
3,5-Bis[(3-bromophenyl)methylidene]-1-methylpiperidin-4-one
CAS 721414-89-7C20H17Br2NO
1-Ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one chemical structure, C27H33NO7
1-Ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one
C27H33NO7
4-Piperidinone, 3,5-bis[[4-(diethylamino)phenyl]methylene]-1-methyl- chemical structure, C28H37N3O, CAS 4367-02-6
4-Piperidinone, 3,5-bis[[4-(diethylamino)phenyl]methylene]-1-methyl-
CAS 4367-02-6C28H37N3O