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Murcko scaffold

Ring system with 2 rings and 24 atoms

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
24
Chemicals
22
With full pages
3
Scaffold SMILES

O=C(CCCC(=O)OCC(=O)c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCCC(=O)OCC(=O)c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-(4-Bromophenyl)-2-oxoethyl 5-(4-fluoroanilino)-5-oxopentanoate chemical structure, C19H17BrFNO4, CAS 352671-37-5
2-(4-Bromophenyl)-2-oxoethyl 5-(4-fluoroanilino)-5-oxopentanoate
CAS 352671-37-5C19H17BrFNO4
2-(4-Methoxyphenyl)-2-oxoethyl 5-oxo-5-((3-(trifluoromethyl)phenyl)amino)pentanoate chemical structure, C21H20F3NO5, CAS 351989-42-9
2-(4-Methoxyphenyl)-2-oxoethyl 5-oxo-5-((3-(trifluoromethyl)phenyl)amino)pentanoate
CAS 351989-42-9C21H20F3NO5
[2-(4-Methoxyphenyl)-2-oxoethyl] 5-(4-acetylanilino)-5-oxopentanoate chemical structure, C22H23NO6, CAS 355818-40-5
[2-(4-Methoxyphenyl)-2-oxoethyl] 5-(4-acetylanilino)-5-oxopentanoate
CAS 355818-40-5C22H23NO6
Methyl 4-({5-[2-(4-chlorophenyl)-2-oxoethoxy]-5-oxopentanoyl}amino)benzoate chemical structure, C21H20ClNO6, CAS 352671-41-1
Methyl 4-({5-[2-(4-chlorophenyl)-2-oxoethoxy]-5-oxopentanoyl}amino)benzoate
CAS 352671-41-1C21H20ClNO6
2-(4-Methoxyphenyl)-2-oxoethyl 5-(3-chloro-4-methylanilino)-5-oxopentanoate chemical structure, C21H22ClNO5, CAS 313393-59-8
2-(4-Methoxyphenyl)-2-oxoethyl 5-(3-chloro-4-methylanilino)-5-oxopentanoate
CAS 313393-59-8C21H22ClNO5
[2-(4-Methyl-3-nitrophenyl)-2-oxoethyl] 5-(4-fluoroanilino)-5-oxopentanoate chemical structure, C20H19FN2O6, CAS 355431-73-1
[2-(4-Methyl-3-nitrophenyl)-2-oxoethyl] 5-(4-fluoroanilino)-5-oxopentanoate
CAS 355431-73-1C20H19FN2O6
[2-(4-Chloro-3-nitrophenyl)-2-oxoethyl] 5-(4-methoxyanilino)-5-oxopentanoate chemical structure, C20H19ClN2O7, CAS 355432-12-1
[2-(4-Chloro-3-nitrophenyl)-2-oxoethyl] 5-(4-methoxyanilino)-5-oxopentanoate
CAS 355432-12-1C20H19ClN2O7
[2-(4-Methyl-3-nitrophenyl)-2-oxoethyl] 5-(4-methoxyanilino)-5-oxopentanoate chemical structure, C21H22N2O7, CAS 355431-75-3
[2-(4-Methyl-3-nitrophenyl)-2-oxoethyl] 5-(4-methoxyanilino)-5-oxopentanoate
CAS 355431-75-3C21H22N2O7
2-(4-Methyl-3-nitrophenyl)-2-oxoethyl 5-[(2,5-dimethylphenyl)amino]-5-oxopentanoate chemical structure, C22H24N2O6, CAS 6462-67-5
2-(4-Methyl-3-nitrophenyl)-2-oxoethyl 5-[(2,5-dimethylphenyl)amino]-5-oxopentanoate
CAS 6462-67-5C22H24N2O6
2-Oxo-2-phenylethyl 5-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-5-oxopentanoate chemical structure, C20H17ClF3NO4, CAS 356098-11-8
2-Oxo-2-phenylethyl 5-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-5-oxopentanoate
CAS 356098-11-8C20H17ClF3NO4
2-(4-Nitrophenyl)-2-oxoethyl 5-((2-chloro-5-(trifluoromethyl)phenyl)amino)-5-oxopentanoate chemical structure, C20H16ClF3N2O6, CAS 356098-15-2
2-(4-Nitrophenyl)-2-oxoethyl 5-((2-chloro-5-(trifluoromethyl)phenyl)amino)-5-oxopentanoate
CAS 356098-15-2C20H16ClF3N2O6
2-(3-Methoxyphenyl)-2-oxoethyl 5-((2-ethylphenyl)amino)-5-oxopentanoate chemical structure, C22H25NO5, CAS 524930-15-2
2-(3-Methoxyphenyl)-2-oxoethyl 5-((2-ethylphenyl)amino)-5-oxopentanoate
CAS 524930-15-2C22H25NO5
2-(4-Nitrophenyl)-2-oxoethyl 4-[N-(4-bromophenyl)carbamoyl]butanoate chemical structure, C19H17BrN2O6, CAS 351989-17-8
2-(4-Nitrophenyl)-2-oxoethyl 4-[N-(4-bromophenyl)carbamoyl]butanoate
CAS 351989-17-8C19H17BrN2O6
2-(4-Methyl-3-nitrophenyl)-2-oxoethyl 5-[(4-methylphenyl)amino]-5-oxopentanoate chemical structure, C21H22N2O6, CAS 355431-78-6
2-(4-Methyl-3-nitrophenyl)-2-oxoethyl 5-[(4-methylphenyl)amino]-5-oxopentanoate
CAS 355431-78-6C21H22N2O6
Methyl 4-[[5-[2-(4-methyl-3-nitrophenyl)-2-oxoethoxy]-5-oxopentanoyl]amino]benzoate chemical structure, C22H22N2O8, CAS 355431-82-2
Methyl 4-[[5-[2-(4-methyl-3-nitrophenyl)-2-oxoethoxy]-5-oxopentanoyl]amino]benzoate
CAS 355431-82-2C22H22N2O8
1-Methyl-2-oxo-2-phenylethyl 5-{4-nitroanilino}-5-oxopentanoate chemical structure, C20H20N2O6, CAS 335391-35-0
1-Methyl-2-oxo-2-phenylethyl 5-{4-nitroanilino}-5-oxopentanoate
CAS 335391-35-0C20H20N2O6
4-p-Tolylcarbamoyl-butyric acid 1-methyl-2-oxo-2-phenyl-ethyl ester chemical structure, C21H23NO4, CAS 335391-38-3
4-p-Tolylcarbamoyl-butyric acid 1-methyl-2-oxo-2-phenyl-ethyl ester
CAS 335391-38-3C21H23NO4
2-(4-Methyl-3-nitrophenyl)-2-oxoethyl 5-((2-chloro-5-(trifluoromethyl)phenyl)amino)-5-oxopentanoate chemical structure, C21H18ClF3N2O6, CAS 356098-19-6
2-(4-Methyl-3-nitrophenyl)-2-oxoethyl 5-((2-chloro-5-(trifluoromethyl)phenyl)amino)-5-oxopentanoate
CAS 356098-19-6C21H18ClF3N2O6
1-Oxo-1-phenylpropan-2-yl 5-((2-methoxyphenyl)amino)-5-oxopentanoate chemical structure, C21H23NO5, CAS 335391-36-1
1-Oxo-1-phenylpropan-2-yl 5-((2-methoxyphenyl)amino)-5-oxopentanoate
CAS 335391-36-1C21H23NO5
[2-(4-Methoxyphenyl)-2-oxoethyl] 5-(4-ethoxyanilino)-5-oxopentanoate chemical structure, C22H25NO6, CAS 351989-31-6
[2-(4-Methoxyphenyl)-2-oxoethyl] 5-(4-ethoxyanilino)-5-oxopentanoate
CAS 351989-31-6C22H25NO6
1-Methyl-2-oxo-2-phenylethyl 5-(4-bromoanilino)-5-oxopentanoate chemical structure, C20H20BrNO4, CAS 335391-34-9
1-Methyl-2-oxo-2-phenylethyl 5-(4-bromoanilino)-5-oxopentanoate
CAS 335391-34-9C20H20BrNO4
2-(4-Fluorophenyl)-2-oxoethyl 5-[(4-fluorophenyl)amino]-5-oxopentanoate chemical structure, C19H17F2NO4, CAS 524046-24-0
2-(4-Fluorophenyl)-2-oxoethyl 5-[(4-fluorophenyl)amino]-5-oxopentanoate
CAS 524046-24-0C19H17F2NO4