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Murcko scaffold

Ring system with 3 rings and 19 atoms

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
36
With full pages
5
Scaffold SMILES

c1ccc(Oc2cnnc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Oc2cnnc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

5-Phenoxy-3-phenyl-6-(trifluoromethyl)-1,2,4-triazine chemical structure, C16H10F3N3O, CAS 383148-40-1
5-Phenoxy-3-phenyl-6-(trifluoromethyl)-1,2,4-triazine
CAS 383148-40-1C16H10F3N3O
Ethyl 5-(4-chlorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H14ClN3O3, CAS 338957-35-0
Ethyl 5-(4-chlorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-35-0C18H14ClN3O3
Ethyl 5-(4-methylphenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O3, CAS 338957-37-2
Ethyl 5-(4-methylphenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-37-2C19H17N3O3
Ethyl 3-phenyl-5-[3-(trifluoromethyl)phenoxy]-1,2,4-triazine-6-carboxylate chemical structure, C19H14F3N3O3, CAS 338957-38-3
Ethyl 3-phenyl-5-[3-(trifluoromethyl)phenoxy]-1,2,4-triazine-6-carboxylate
CAS 338957-38-3C19H14F3N3O3
Ethyl 5-(4-fluorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H14FN3O3, CAS 338957-39-4
Ethyl 5-(4-fluorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-39-4C18H14FN3O3
Ethyl 5-(2,6-dichlorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H13Cl2N3O3, CAS 338957-40-7
Ethyl 5-(2,6-dichlorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-40-7C18H13Cl2N3O3
Ethyl 5-(2,6-dimethylphenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C20H19N3O3, CAS 338957-41-8
Ethyl 5-(2,6-dimethylphenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-41-8C20H19N3O3
Ethyl 5-(2-chlorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C18H14ClN3O3, CAS 338957-42-9
Ethyl 5-(2-chlorophenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-42-9C18H14ClN3O3
Ethyl 5-(4-methoxyphenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O4, CAS 338957-43-0
Ethyl 5-(4-methoxyphenoxy)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338957-43-0C19H17N3O4
Ethyl 5-phenoxy-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C19H14F3N3O3, CAS 338957-78-1
Ethyl 5-phenoxy-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-78-1C19H14F3N3O3
Ethyl 5-(4-chlorophenoxy)-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C19H13ClF3N3O3, CAS 338957-79-2
Ethyl 5-(4-chlorophenoxy)-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-79-2C19H13ClF3N3O3
Ethyl 5-[3-(trifluoromethyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C20H13F6N3O3, CAS 338957-80-5
Ethyl 5-[3-(trifluoromethyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-80-5C20H13F6N3O3
Ethyl 5-[2-(methoxycarbonyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C21H16F3N3O5, CAS 338957-81-6
Ethyl 5-[2-(methoxycarbonyl)phenoxy]-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338957-81-6C21H16F3N3O5
Ethyl 5-(4-methoxyphenoxy)-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate chemical structure, C20H16F3N3O4, CAS 338959-68-5
Ethyl 5-(4-methoxyphenoxy)-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-6-carboxylate
CAS 338959-68-5C20H16F3N3O4
4-({6-Methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-yl}oxy)benzenecarbonitrile chemical structure, C18H11F3N4O, CAS 339103-87-6
4-({6-Methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-yl}oxy)benzenecarbonitrile
CAS 339103-87-6C18H11F3N4O
5-(2,4-Dichlorophenoxy)-6-methyl-3-(4-methylphenyl)-1,2,4-triazine chemical structure, C17H13Cl2N3O, CAS 478260-75-2
5-(2,4-Dichlorophenoxy)-6-methyl-3-(4-methylphenyl)-1,2,4-triazine
CAS 478260-75-2C17H13Cl2N3O
5-(4-Methylphenoxy)-3-phenyl-6-(trifluoromethyl)-1,2,4-triazine chemical structure, C17H12F3N3O, CAS 672950-81-1
5-(4-Methylphenoxy)-3-phenyl-6-(trifluoromethyl)-1,2,4-triazine
CAS 672950-81-1C17H12F3N3O
5-(4-Fluorophenoxy)-3-phenyl-6-(trifluoromethyl)-1,2,4-triazine chemical structure, C16H9F4N3O, CAS 672950-87-7
5-(4-Fluorophenoxy)-3-phenyl-6-(trifluoromethyl)-1,2,4-triazine
CAS 672950-87-7C16H9F4N3O
Ethyl 3-(4-methylphenyl)-5-[3-(trifluoromethyl)phenoxy]-1,2,4-triazine-6-carboxylate chemical structure, C20H16F3N3O3, CAS 338966-14-6
Ethyl 3-(4-methylphenyl)-5-[3-(trifluoromethyl)phenoxy]-1,2,4-triazine-6-carboxylate
CAS 338966-14-6C20H16F3N3O3
Ethyl 5-(4-methoxyphenoxy)-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate chemical structure, C20H19N3O4, CAS 338966-15-7
Ethyl 5-(4-methoxyphenoxy)-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate
CAS 338966-15-7C20H19N3O4
Ethyl 5-(2,4-dichlorophenoxy)-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate chemical structure, C19H15Cl2N3O3, CAS 338966-16-8
Ethyl 5-(2,4-dichlorophenoxy)-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate
CAS 338966-16-8C19H15Cl2N3O3
Ethyl 5-[2-(methoxycarbonyl)phenoxy]-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate chemical structure, C21H19N3O5, CAS 338966-17-9
Ethyl 5-[2-(methoxycarbonyl)phenoxy]-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate
CAS 338966-17-9C21H19N3O5
Ethyl 5-(2-chlorophenoxy)-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate chemical structure, C19H16ClN3O3, CAS 338965-90-5
Ethyl 5-(2-chlorophenoxy)-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate
CAS 338965-90-5C19H16ClN3O3
Ethyl 3-(4-methylphenyl)-5-phenoxy-1,2,4-triazine-6-carboxylate chemical structure, C19H17N3O3, CAS 338965-89-2
Ethyl 3-(4-methylphenyl)-5-phenoxy-1,2,4-triazine-6-carboxylate
CAS 338965-89-2C19H17N3O3