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Murcko scaffold

Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one scaffold

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
16
With full pages
1
Scaffold SMILES

O=C1Nc2ccccc2C2(CCNCC2)O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one page
Murcko scaffold O=C1Nc2ccccc2C2(CCNCC2)O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

6-Methyl-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one chemical structure, C13H16N2O2, CAS 233261-86-4
6-Methyl-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one
CAS 233261-86-4C13H16N2O2
1'-Boc-1,2-Dihydro-2-oxo-spiro[4H-3,1-benzoxazine-4,4'-piperidine] chemical structure, C17H22N2O4, CAS 84060-08-2
1'-Boc-1,2-Dihydro-2-oxo-spiro[4H-3,1-benzoxazine-4,4'-piperidine]
CAS 84060-08-2C17H22N2O4
Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one chemical structure, C12H14N2O2, CAS 84060-09-3
Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
CAS 84060-09-3C12H14N2O2
1,2-Dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one hydrochloride chemical structure, C12H15ClN2O2, CAS 85732-37-2
1,2-Dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one hydrochloride
CAS 85732-37-2C12H15ClN2O2
1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one chemical structure, C13H16N2O2, CAS 84060-10-6
1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
CAS 84060-10-6C13H16N2O2
1'-Boc-6-chlorospiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one chemical structure, C17H21ClN2O4, CAS 332187-61-8
1'-Boc-6-chlorospiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
CAS 332187-61-8C17H21ClN2O4
tert-Butyl 6-fluoro-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-carboxylate chemical structure, C17H21FN2O4, CAS 345938-08-1
tert-Butyl 6-fluoro-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-carboxylate
CAS 345938-08-1C17H21FN2O4
6-Chloro-1,2-dihydro-2-oxospiro[4H-3,1-benzoxazin-4,4'-piperidine] chemical structure, C12H13ClN2O2, CAS 92926-63-1
6-Chloro-1,2-dihydro-2-oxospiro[4H-3,1-benzoxazin-4,4'-piperidine]
CAS 92926-63-1C12H13ClN2O2
6-Chloro-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one hydrochloride chemical structure, C12H14Cl2N2O2, CAS 85732-39-4
6-Chloro-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one hydrochloride
CAS 85732-39-4C12H14Cl2N2O2
6-Fluorospiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one chemical structure, C12H13FN2O2, CAS 92926-32-4
6-Fluorospiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
CAS 92926-32-4C12H13FN2O2
6-Bromospiro[benzo[D][1,3]oxazine-4,4'-piperidin]-2(1H)-one chemical structure, C12H13BrN2O2, CAS 92926-60-8
6-Bromospiro[benzo[D][1,3]oxazine-4,4'-piperidin]-2(1H)-one
CAS 92926-60-8C12H13BrN2O2
2-Oxo-1,2-dihydrospiro[[3,1]benzoxazine-4,4'-piperidine]-6-carbonitrile chemical structure, C13H13N3O2, CAS 92926-35-7
2-Oxo-1,2-dihydrospiro[[3,1]benzoxazine-4,4'-piperidine]-6-carbonitrile
CAS 92926-35-7C13H13N3O2
6-Fluoro-1-methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one chemical structure, C13H15FN2O2, CAS 1036926-64-3
6-Fluoro-1-methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
CAS 1036926-64-3C13H15FN2O2
6-Methoxyspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one chemical structure, C13H16N2O3, CAS 1893182-42-7
6-Methoxyspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
CAS 1893182-42-7C13H16N2O3
6-Methyl-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-onehydrochloride chemical structure, C13H17ClN2O2, CAS 603152-35-8
6-Methyl-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-onehydrochloride
CAS 603152-35-8C13H17ClN2O2
6-Fluoro-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one hydrochloride chemical structure, C12H14ClFN2O2, CAS 1036926-61-0
6-Fluoro-1,2-dihydrospiro[3,1-benzoxazine-4,4'-piperidine]-2-one hydrochloride
CAS 1036926-61-0C12H14ClFN2O2