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Murcko scaffold

Ring system with 3 rings and 16 atoms

60 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
60
With full pages
27
Scaffold SMILES

c1ccc(Cn2ncc3cncnc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Cn2ncc3cncnc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 60 chemicals

1-Benzyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H11N5, CAS 5444-61-1
1-Benzyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5444-61-1C12H11N5
1-Benzyl-4,6-bis(methylthio)-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C14H14N4S2, CAS 126867-57-0
1-Benzyl-4,6-bis(methylthio)-1H-pyrazolo[3,4-d]pyrimidine
CAS 126867-57-0C14H14N4S2
1-Benzyl-4-hydrazinyl-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C12H12N6, CAS 329707-65-5
1-Benzyl-4-hydrazinyl-1H-pyrazolo[3,4-d]pyrimidine
CAS 329707-65-5C12H12N6
1-Benzyl-N-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H19N5, CAS 370851-76-6
1-Benzyl-N-tert-butylpyrazolo[3,4-d]pyrimidin-4-amine
CAS 370851-76-6C16H19N5
1-(4-Chlorobenzyl)-N,N-diethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H18ClN5, CAS 612523-77-0
1-(4-Chlorobenzyl)-N,N-diethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 612523-77-0C16H18ClN5
1-[(4-Chlorophenyl)methyl]-4-hydrazinyl-1H-pyrazolo[3,4-d]pyrimidine chemical structure, C12H11ClN6, CAS 610279-50-0
1-[(4-Chlorophenyl)methyl]-4-hydrazinyl-1H-pyrazolo[3,4-d]pyrimidine
CAS 610279-50-0C12H11ClN6
N,N-Diethyl-1-[(4-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C17H21N5, CAS 612524-09-1
N,N-Diethyl-1-[(4-methylphenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine
CAS 612524-09-1C17H21N5
4-Hydrazinyl-1-((4-methylphenyl)methyl)-1H-pyrazolo(3,4-d)pyrimidine chemical structure, C13H14N6, CAS 610279-48-6
4-Hydrazinyl-1-((4-methylphenyl)methyl)-1H-pyrazolo(3,4-d)pyrimidine
CAS 610279-48-6C13H14N6
1-[(4-Chlorophenyl)methyl]-N-(2-methylpropyl)pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H18ClN5, CAS 612524-00-2
1-[(4-Chlorophenyl)methyl]-N-(2-methylpropyl)pyrazolo[3,4-d]pyrimidin-4-amine
CAS 612524-00-2C16H18ClN5
1-(4-Chlorobenzyl)-N-(2-methoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H16ClN5O, CAS 612523-74-7
1-(4-Chlorobenzyl)-N-(2-methoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 612523-74-7C15H16ClN5O
N-(2-Methoxyethyl)-1-(4-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H19N5O, CAS 612524-06-8
N-(2-Methoxyethyl)-1-(4-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 612524-06-8C16H19N5O
1-(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)sulfanyl-3,3-dimethylbutan-2-one chemical structure, C18H20N4OS, CAS 850899-73-9
1-(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)sulfanyl-3,3-dimethylbutan-2-one
CAS 850899-73-9C18H20N4OS
N-Butan-2-yl-1-[(4-chlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H18ClN5, CAS 612523-96-3
N-Butan-2-yl-1-[(4-chlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-amine
CAS 612523-96-3C16H18ClN5
2-[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)amino]ethanol chemical structure, C14H15N5O, CAS 159599-51-6
2-[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)amino]ethanol
CAS 159599-51-6C14H15N5O
1-Benzyl-4-chloro-6-(trifluoromethyl)-1H-pyrazolo(3,4-d)pyrimidine chemical structure, C13H8ClF3N4, CAS 871547-71-6
1-Benzyl-4-chloro-6-(trifluoromethyl)-1H-pyrazolo(3,4-d)pyrimidine
CAS 871547-71-6C13H8ClF3N4
1-(4-Chlorobenzyl)-N-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H16ClN5, CAS 903188-36-3
1-(4-Chlorobenzyl)-N-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 903188-36-3C15H16ClN5
N,N-Dimethyl-N'-[1-(4-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine chemical structure, C17H22N6, CAS 903866-97-7
N,N-Dimethyl-N'-[1-(4-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]ethane-1,2-diamine
CAS 903866-97-7C17H22N6
1-[(2-Chlorophenyl)methyl]-N-[3-(dimethylamino)propyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C17H21ClN6, CAS 903196-12-3
1-[(2-Chlorophenyl)methyl]-N-[3-(dimethylamino)propyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 903196-12-3C17H21ClN6
1-(2-Chlorobenzyl)-N-(2-methoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H16ClN5O, CAS 903853-22-5
1-(2-Chlorobenzyl)-N-(2-methoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 903853-22-5C15H16ClN5O
1-(2-Chlorobenzyl)-N-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C15H16ClN5, CAS 903858-90-2
1-(2-Chlorobenzyl)-N-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 903858-90-2C15H16ClN5
1-(2-Chlorobenzyl)-N-(3-methylbutyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C17H20ClN5, CAS 903861-86-9
1-(2-Chlorobenzyl)-N-(3-methylbutyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 903861-86-9C17H20ClN5
1-(2-Chlorobenzyl)-N-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H18ClN5, CAS 903203-68-9
1-(2-Chlorobenzyl)-N-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 903203-68-9C16H18ClN5
Butyl{1-[(4-chlorophenyl)methyl]pyrazolo[4,5-e]pyrimidin-4-yl}amine chemical structure, C16H18ClN5, CAS 903192-31-4
Butyl{1-[(4-chlorophenyl)methyl]pyrazolo[4,5-e]pyrimidin-4-yl}amine
CAS 903192-31-4C16H18ClN5
N,N-Dimethyl-N'-[1-(4-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]propane-1,3-diamine chemical structure, C18H24N6, CAS 903192-66-5
N,N-Dimethyl-N'-[1-(4-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]propane-1,3-diamine
CAS 903192-66-5C18H24N6