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Murcko scaffold

Ring system with 3 rings and 20 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
9
With full pages
5
Scaffold SMILES

O=C(Nc1ccccn1)c1ccc2c(c1)C(=O)NC2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccn1)c1ccc2c(c1)C(=O)NC2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

2-(2-Methylpropyl)-1,3-dioxo-N-pyridin-2-ylisoindole-5-carboxamide chemical structure, C18H17N3O3, CAS 497062-80-3
2-(2-Methylpropyl)-1,3-dioxo-N-pyridin-2-ylisoindole-5-carboxamide
CAS 497062-80-3C18H17N3O3
2-(3-Methylbutyl)-N-(4-methylpyridin-2-yl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C20H21N3O3, CAS 774187-05-2
2-(3-Methylbutyl)-N-(4-methylpyridin-2-yl)-1,3-dioxoisoindole-5-carboxamide
CAS 774187-05-2C20H21N3O3
2-(2-Methylpropyl)-N-(4-methylpyridin-2-yl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C19H19N3O3, CAS 774186-32-2
2-(2-Methylpropyl)-N-(4-methylpyridin-2-yl)-1,3-dioxoisoindole-5-carboxamide
CAS 774186-32-2C19H19N3O3
2-Methyl-N-(4-methylpyridin-2-yl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C16H13N3O3, CAS 774186-30-0
2-Methyl-N-(4-methylpyridin-2-yl)-1,3-dioxoisoindole-5-carboxamide
CAS 774186-30-0C16H13N3O3
N-(5-Bromopyridin-2-yl)-2-(2-methylpropyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C18H16BrN3O3, CAS 842119-59-9
N-(5-Bromopyridin-2-yl)-2-(2-methylpropyl)-1,3-dioxoisoindole-5-carboxamide
CAS 842119-59-9C18H16BrN3O3
2-(3-Methylbutyl)-1,3-dioxo-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C19H19N3O3, CAS 1030522-48-5
2-(3-Methylbutyl)-1,3-dioxo-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1030522-48-5C19H19N3O3
1,3-Dioxo-2-(prop-2-en-1-yl)-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C17H13N3O3, CAS 1088165-08-5
1,3-Dioxo-2-(prop-2-en-1-yl)-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1088165-08-5C17H13N3O3
2-(2-Methoxyethyl)-1,3-dioxo-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C17H15N3O4, CAS 1030522-53-2
2-(2-Methoxyethyl)-1,3-dioxo-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1030522-53-2C17H15N3O4
1,3-Dioxo-2-[3-(propan-2-yloxy)propyl]-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide chemical structure, C20H21N3O4, CAS 1144473-48-2
1,3-Dioxo-2-[3-(propan-2-yloxy)propyl]-N-(pyridin-2-yl)-2,3-dihydro-1H-isoindole-5-carboxamide
CAS 1144473-48-2C20H21N3O4