Murcko scaffold
Ring system with 3 rings and 18 atoms
69 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 18
- Chemicals
- 69
- With full pages
- 20
Scaffold SMILES
O=c1[nH]c(SCc2ccccc2)nc2sccc12
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1[nH]c(SCc2ccccc2)nc2sccc12](/scaffold/QRXXBGREQCHFDW-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 69 chemicals
![2-(Benzylsulfanyl)-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H16N2OS2, CAS 312285-52-2](/s/WCFFURSZJHAZJV-UHFFFAOYSA-N.svg)
2-(Benzylsulfanyl)-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 312285-52-2C16H16N2OS2
![3-Allyl-2-(benzylsulfanyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C17H16N2OS2, CAS 499134-22-4](/s/RKCVKFKGQKJEBW-UHFFFAOYSA-N.svg)
3-Allyl-2-(benzylsulfanyl)-6-methylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 499134-22-4C17H16N2OS2
![2-Benzylsulfanyl-6-ethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one chemical structure, C18H18N2OS2, CAS 380474-66-8](/s/ONRTZWUVSVJWFI-UHFFFAOYSA-N.svg)
2-Benzylsulfanyl-6-ethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one
CAS 380474-66-8C18H18N2OS2
![3-Allyl-2-(benzylsulfanyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C18H18N2OS2, CAS 324057-32-1](/s/VGQIWUSCQTYHDI-UHFFFAOYSA-N.svg)
3-Allyl-2-(benzylsulfanyl)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 324057-32-1C18H18N2OS2
3-Ethyl-2-((4-fluorobenzyl)thio)-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one
CAS 618427-51-3C17H17FN2OS2
![2-[(3-Fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H15FN2OS2, CAS 678540-58-4](/s/BVYUJGDMLQLPAN-UHFFFAOYSA-N.svg)
2-[(3-Fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 678540-58-4C16H15FN2OS2
![2-[(3-Methoxybenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C17H18N2O2S2, CAS 752990-18-4](/s/WUVIMJSFZSFBSW-UHFFFAOYSA-N.svg)
2-[(3-Methoxybenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 752990-18-4C17H18N2O2S2
![3,5,6-Trimethyl-2-[(3-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C17H18N2OS2, CAS 678556-66-6](/s/AJZBYHWFVPUSSP-UHFFFAOYSA-N.svg)
3,5,6-Trimethyl-2-[(3-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
CAS 678556-66-6C17H18N2OS2
3-Ethyl-5,6-dimethyl-2-((2-methylbenzyl)thio)thieno(2,3-D)pyrimidin-4(3H)-one
CAS 618427-53-5C18H20N2OS2
3-Ethyl-2-((3-fluorobenzyl)thio)-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one
CAS 573669-02-0C17H17FN2OS2
3-Ethyl-5,6-dimethyl-2-((4-methylbenzyl)thio)thieno(2,3-D)pyrimidin-4(3H)-one
CAS 573670-03-8C18H20N2OS2
3-Ethyl-2-((2-fluorobenzyl)thio)-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one
CAS 573706-13-5C17H17FN2OS2
![2-[(2-Fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H15FN2OS2, CAS 577765-22-1](/s/QZSJCOKEYXCJTM-UHFFFAOYSA-N.svg)
2-[(2-Fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 577765-22-1C16H15FN2OS2
![3,5,6-Trimethyl-2-[(2-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C17H18N2OS2, CAS 578756-78-2](/s/RROAQYCMXYPPQT-UHFFFAOYSA-N.svg)
3,5,6-Trimethyl-2-[(2-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
CAS 578756-78-2C17H18N2OS2
![2-[(2,5-Dimethylbenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C18H20N2OS2, CAS 577698-44-3](/s/MQJROXXVFUIJKC-UHFFFAOYSA-N.svg)
2-[(2,5-Dimethylbenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 577698-44-3C18H20N2OS2
![2-[(4-Fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C16H15FN2OS2, CAS 577700-06-2](/s/FEWKKUAKHUOHGW-UHFFFAOYSA-N.svg)
2-[(4-Fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one
CAS 577700-06-2C16H15FN2OS2
![3-Ethyl-5,6-dimethyl-2-[(3-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C18H20N2OS2, CAS 577959-82-1](/s/AFGWBKRGOYMMBC-UHFFFAOYSA-N.svg)
3-Ethyl-5,6-dimethyl-2-[(3-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
CAS 577959-82-1C18H20N2OS2
2-(Benzylthio)-3-ethyl-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one
CAS 587011-26-5C17H18N2OS2
![3,5,6-Trimethyl-2-[(4-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C17H18N2OS2, CAS 587011-05-0](/s/NUBTYXDKBTUJHS-UHFFFAOYSA-N.svg)
3,5,6-Trimethyl-2-[(4-methylbenzyl)sulfanyl]thieno[2,3-d]pyrimidin-4(3H)-one
CAS 587011-05-0C17H18N2OS2
![2-{[(2-Fluorophenyl)methyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C18H17FN2OS2, CAS 314261-84-2](/s/WHJMIYVWSIPBMS-UHFFFAOYSA-N.svg)
2-{[(2-Fluorophenyl)methyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one
CAS 314261-84-2C18H17FN2OS2
![Methyl 4-[(5,6-dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylmethyl]benzoate chemical structure, C20H20N2O3S2, CAS 325693-48-9](/s/FZEZMLHSQXUFFK-UHFFFAOYSA-N.svg)
Methyl 4-[(5,6-dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylmethyl]benzoate
CAS 325693-48-9C20H20N2O3S2
![2-Benzylsulfanyl-3,6-dimethylthieno[2,3-d]pyrimidin-4-one chemical structure, C15H14N2OS2, CAS 717829-60-2](/s/SARUKUCDCVXTHI-UHFFFAOYSA-N.svg)
2-Benzylsulfanyl-3,6-dimethylthieno[2,3-d]pyrimidin-4-one
CAS 717829-60-2C15H14N2OS2
![5,6-Dimethyl-2-[(4-nitrophenyl)methylsulfanyl]-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one chemical structure, C18H17N3O3S2, CAS 679821-72-8](/s/YJTQLWNWLZXEHS-UHFFFAOYSA-N.svg)
5,6-Dimethyl-2-[(4-nitrophenyl)methylsulfanyl]-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one
CAS 679821-72-8C18H17N3O3S2
![2-[(4-Chlorophenyl)methylsulfanyl]-5,6-dimethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one chemical structure, C18H17ClN2OS2, CAS 380211-40-5](/s/POZFBNWQULUYBT-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)methylsulfanyl]-5,6-dimethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one
CAS 380211-40-5C18H17ClN2OS2
- 2-[(4-Chlorophenyl)methylsulfanyl]-6-ethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one380453-41-8C18H17ClN2OS2
- 2-[(2-Chlorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one462075-19-0C16H15ClN2OS2
- 4-(((5,6-Dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)methyl)-N-(2-hydroxyethyl)benzamide325693-59-2C18H19N3O3S2
- 2-[(2,6-Difluorobenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one573942-49-1C18H16F2N2OS2
- 2-[(2-Chlorobenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one573943-58-5C18H17ClN2OS2
- 2-((2,5-Dimethylbenzyl)thio)-3-ET-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one573945-48-9C19H22N2OS2
- 2-[(2,6-Dichlorobenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one678558-28-6C18H16Cl2N2OS2
- 2-[(3-Bromobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one678984-68-4C16H15BrN2OS2
- 2-[(2,5-Dimethylbenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one677329-93-0C20H22N2OS2
- 2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one678978-72-8C18H16ClFN2OS2
- 4-(3-Allyl-5,6-dimethyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidin-2-ylsulfanylmethyl)-benzoic acid678146-42-4C19H18N2O3S2
- 4-[(5,6-Dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylmethyl]-N-(2-hydroxyethyl)benzamide325693-42-3C21H23N3O3S2
- 2-[(2,4-Dichlorophenyl)methylsulfanyl]-6-ethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one380455-19-6C18H16Cl2N2OS2
- 2-[(4-tert-Butylbenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one676640-63-4C20H24N2OS2
- 2-((3-Chlorobenzyl)thio)-3-ethyl-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one577988-96-6C17H17ClN2OS2
- 5,6-Dimethyl-2-[(4-methylbenzyl)sulfanyl]-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one577989-23-2C19H20N2OS2
- 2-[(3-Bromobenzyl)sulfanyl]-3-ethyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one679416-17-2C17H17BrN2OS2
- 2-[(3-Fluorobenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one578753-86-3C18H17FN2OS2
- 5,6-Dimethyl-2-[(3-methylbenzyl)sulfanyl]-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one678972-19-5C19H20N2OS2
- 2-[(2-Chloro-6-fluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one578761-21-4C16H14ClFN2OS2
- 3-Ethyl-2-[(3-methoxybenzyl)sulfanyl]-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one578761-63-4C18H20N2O2S2
- 2-[(2,4-Dichlorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one575460-57-0C16H14Cl2N2OS2
- 2-[(2,6-Difluorobenzyl)sulfanyl]-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one577788-23-9C16H14F2N2OS2
- 2-[(4-Bromobenzyl)sulfanyl]-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one585552-01-8C18H17BrN2OS2
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