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Murcko scaffold

Ring system with 3 rings and 20 atoms

106 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
106
With full pages
26
Scaffold SMILES

O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)NC2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)NC2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 106 chemicals

2-tert-Butyl-N-(4-hydroxyphenyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C19H18N2O4, CAS 305361-47-1
2-tert-Butyl-N-(4-hydroxyphenyl)-1,3-dioxoisoindole-5-carboxamide
CAS 305361-47-1C19H18N2O4
2-tert-Butyl-N-(3-hydroxyphenyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C19H18N2O4, CAS 294891-61-5
2-tert-Butyl-N-(3-hydroxyphenyl)-1,3-dioxoisoindole-5-carboxamide
CAS 294891-61-5C19H18N2O4
N-(5-Chloro-2-hydroxyphenyl)-2-methyl-1,3-dioxoisoindole-5-carboxamide chemical structure, C16H11ClN2O4, CAS 434294-78-7
N-(5-Chloro-2-hydroxyphenyl)-2-methyl-1,3-dioxoisoindole-5-carboxamide
CAS 434294-78-7C16H11ClN2O4
3-{[(2-Ethyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C18H14N2O5, CAS 500261-60-9
3-{[(2-Ethyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 500261-60-9C18H14N2O5
N-(5-Chloro-2-hydroxyphenyl)-2-ethyl-1,3-dioxoisoindole-5-carboxamide chemical structure, C17H13ClN2O4, CAS 519147-44-5
N-(5-Chloro-2-hydroxyphenyl)-2-ethyl-1,3-dioxoisoindole-5-carboxamide
CAS 519147-44-5C17H13ClN2O4
4-Methyl-3-{[(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C18H14N2O5, CAS 519147-49-0
4-Methyl-3-{[(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 519147-49-0C18H14N2O5
2-Methyl-3-{[(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C18H14N2O5, CAS 667410-64-2
2-Methyl-3-{[(2-methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 667410-64-2C18H14N2O5
2-{[(2-Methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C17H12N2O5, CAS 378773-33-2
2-{[(2-Methyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 378773-33-2C17H12N2O5
N-(2-Hydroxyphenyl)-2-(2-methylpropyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C19H18N2O4, CAS 369398-87-8
N-(2-Hydroxyphenyl)-2-(2-methylpropyl)-1,3-dioxoisoindole-5-carboxamide
CAS 369398-87-8C19H18N2O4
N-(2-Hydroxyphenyl)-2-methyl-1,3-dioxoisoindole-5-carboxamide chemical structure, C16H12N2O4, CAS 518022-19-0
N-(2-Hydroxyphenyl)-2-methyl-1,3-dioxoisoindole-5-carboxamide
CAS 518022-19-0C16H12N2O4
N-(2-Ethoxyphenyl)-2-methyl-1,3-dioxoisoindole-5-carboxamide chemical structure, C18H16N2O4, CAS 518022-29-2
N-(2-Ethoxyphenyl)-2-methyl-1,3-dioxoisoindole-5-carboxamide
CAS 518022-29-2C18H16N2O4
N-(2-Hydroxy-5-methylphenyl)-1,3-dioxo-2-propyl-5-isoindolecarboxamide chemical structure, C19H18N2O4, CAS 518010-96-3
N-(2-Hydroxy-5-methylphenyl)-1,3-dioxo-2-propyl-5-isoindolecarboxamide
CAS 518010-96-3C19H18N2O4
N-(3-Hydroxyphenyl)-1,3-dioxo-2-propylisoindole-5-carboxamide chemical structure, C18H16N2O4, CAS 518010-98-5
N-(3-Hydroxyphenyl)-1,3-dioxo-2-propylisoindole-5-carboxamide
CAS 518010-98-5C18H16N2O4
5-Bromo-2-[(2-methyl-1,3-dioxoisoindole-5-carbonyl)amino]benzoic acid chemical structure, C17H11BrN2O5, CAS 354121-07-6
5-Bromo-2-[(2-methyl-1,3-dioxoisoindole-5-carbonyl)amino]benzoic acid
CAS 354121-07-6C17H11BrN2O5
2-{[(1,3-Dioxo-2-propyl-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C19H16N2O5, CAS 500261-61-0
2-{[(1,3-Dioxo-2-propyl-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 500261-61-0C19H16N2O5
5-Bromo-2-{[(2-ethyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C18H13BrN2O5, CAS 500261-62-1
5-Bromo-2-{[(2-ethyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 500261-62-1C18H13BrN2O5
5-Bromo-2-{[(1,3-dioxo-2-propyl-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C19H15BrN2O5, CAS 500262-25-9
5-Bromo-2-{[(1,3-dioxo-2-propyl-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 500262-25-9C19H15BrN2O5
Methyl (4-{[(2-tert-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}phenoxy)acetate chemical structure, C22H22N2O6, CAS 500263-69-4
Methyl (4-{[(2-tert-butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}phenoxy)acetate
CAS 500263-69-4C22H22N2O6
2-(2-Methylpropyl)-1,3-dioxo-N-(2,4,6-trimethylphenyl)isoindole-5-carboxamide chemical structure, C22H24N2O3, CAS 665025-89-8
2-(2-Methylpropyl)-1,3-dioxo-N-(2,4,6-trimethylphenyl)isoindole-5-carboxamide
CAS 665025-89-8C22H24N2O3
N-(2-Hydroxy-5-methylphenyl)-2-(3-methylbutyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C21H22N2O4, CAS 666710-87-8
N-(2-Hydroxy-5-methylphenyl)-2-(3-methylbutyl)-1,3-dioxoisoindole-5-carboxamide
CAS 666710-87-8C21H22N2O4
N-[3-(tert-Butylcarbamoyl)phenyl]-2-ethyl-1,3-dioxoisoindole-5-carboxamide chemical structure, C22H23N3O4, CAS 666710-98-1
N-[3-(tert-Butylcarbamoyl)phenyl]-2-ethyl-1,3-dioxoisoindole-5-carboxamide
CAS 666710-98-1C22H23N3O4
4-{[(2-tert-Butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid chemical structure, C20H18N2O5, CAS 6044-16-2
4-{[(2-tert-Butyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)carbonyl]amino}benzoic acid
CAS 6044-16-2C20H18N2O5
2-tert-Butyl-N-(3-iodophenyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C19H17IN2O3, CAS 294891-43-3
2-tert-Butyl-N-(3-iodophenyl)-1,3-dioxoisoindole-5-carboxamide
CAS 294891-43-3C19H17IN2O3
N-(3-Iodophenyl)-2-(2-methylpropyl)-1,3-dioxoisoindole-5-carboxamide chemical structure, C19H17IN2O3, CAS 305358-42-3
N-(3-Iodophenyl)-2-(2-methylpropyl)-1,3-dioxoisoindole-5-carboxamide
CAS 305358-42-3C19H17IN2O3