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Murcko scaffold

Ring system with 2 rings and 13 atoms

83 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
83
With full pages
3
Scaffold SMILES

O=C(Nc1cccs1)c1ccn[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccs1)c1ccn[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 83 chemicals

Methyl 4,5-dimethyl-2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C13H15N3O3S, CAS 309923-07-7
Methyl 4,5-dimethyl-2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}thiophene-3-carboxylate
CAS 309923-07-7C13H15N3O3S
Ethyl 4,5-dimethyl-2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3-thiophenecarboxylate chemical structure, C14H17N3O3S, CAS 293764-70-2
Ethyl 4,5-dimethyl-2-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-3-thiophenecarboxylate
CAS 293764-70-2C14H17N3O3S
N-(3-Carbamoyl-5-propan-2-ylthiophen-2-yl)-4-chloro-1-ethylpyrazole-3-carboxamide chemical structure, C14H17ClN4O2S, CAS 512817-48-0
N-(3-Carbamoyl-5-propan-2-ylthiophen-2-yl)-4-chloro-1-ethylpyrazole-3-carboxamide
CAS 512817-48-0C14H17ClN4O2S
4-Isopropyl 2-methyl 3-methyl-5-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-2,4-thiophenedicarboxylate chemical structure, C16H19N3O5S, CAS 492426-53-6
4-Isopropyl 2-methyl 3-methyl-5-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-2,4-thiophenedicarboxylate
CAS 492426-53-6C16H19N3O5S
Diethyl 5-{[(4-bromo-1-ethyl-1H-pyrazol-5-yl)carbonyl]amino}-3-methyl-2,4-thiophenedicarboxylate chemical structure, C17H20BrN3O5S, CAS 515849-11-3
Diethyl 5-{[(4-bromo-1-ethyl-1H-pyrazol-5-yl)carbonyl]amino}-3-methyl-2,4-thiophenedicarboxylate
CAS 515849-11-3C17H20BrN3O5S
2-Ethyl 4-methyl 3-methyl-5-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-2,4-thiophenedicarboxylate chemical structure, C15H17N3O5S, CAS 494217-10-6
2-Ethyl 4-methyl 3-methyl-5-{[(1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-2,4-thiophenedicarboxylate
CAS 494217-10-6C15H17N3O5S
Diethyl 3-methyl-5-(1-methyl-1H-pyrazole-5-carboxamido)thiophene-2,4-dicarboxylate chemical structure, C16H19N3O5S, CAS 494217-19-5
Diethyl 3-methyl-5-(1-methyl-1H-pyrazole-5-carboxamido)thiophene-2,4-dicarboxylate
CAS 494217-19-5C16H19N3O5S
4-Bromo-N-(3-carbamoyl-5-propan-2-ylthiophen-2-yl)-1,5-dimethylpyrazole-3-carboxamide chemical structure, C14H17BrN4O2S, CAS 512824-75-8
4-Bromo-N-(3-carbamoyl-5-propan-2-ylthiophen-2-yl)-1,5-dimethylpyrazole-3-carboxamide
CAS 512824-75-8C14H17BrN4O2S
Ethyl 2-[(4-bromo-2-methylpyrazole-3-carbonyl)amino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C18H23BrN4O4S, CAS 491832-16-7
Ethyl 2-[(4-bromo-2-methylpyrazole-3-carbonyl)amino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 491832-16-7C18H23BrN4O4S
Ethyl 2-[(4-bromo-1-methylpyrazole-3-carbonyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C14H16BrN3O3S, CAS 957319-85-6
Ethyl 2-[(4-bromo-1-methylpyrazole-3-carbonyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 957319-85-6C14H16BrN3O3S
Dimethyl 5-[(1-ethylpyrazole-3-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C15H17N3O5S, CAS 494217-08-2
Dimethyl 5-[(1-ethylpyrazole-3-carbonyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 494217-08-2C15H17N3O5S
Methyl 2-(4-bromo-1-methyl-1H-pyrazole-3-carboxamido)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C17H21BrN4O4S, CAS 309285-91-4
Methyl 2-(4-bromo-1-methyl-1H-pyrazole-3-carboxamido)-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 309285-91-4C17H21BrN4O4S
2-[[(4-Bromo-1-ethyl-3-pyrazolyl)-oxomethyl]amino]-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester chemical structure, C15H18BrN3O3S, CAS 494217-14-0
2-[[(4-Bromo-1-ethyl-3-pyrazolyl)-oxomethyl]amino]-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester
CAS 494217-14-0C15H18BrN3O3S
4-Bromo-N-(3-carbamoyl-5-propan-2-ylthiophen-2-yl)-1-methylpyrazole-3-carboxamide chemical structure, C13H15BrN4O2S, CAS 494790-62-4
4-Bromo-N-(3-carbamoyl-5-propan-2-ylthiophen-2-yl)-1-methylpyrazole-3-carboxamide
CAS 494790-62-4C13H15BrN4O2S
Ethyl 4-cyano-5-({[1-(difluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-methylthiophene-2-carboxylate chemical structure, C14H12F2N4O3S, CAS 1005633-91-9
Ethyl 4-cyano-5-({[1-(difluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-3-methylthiophene-2-carboxylate
CAS 1005633-91-9C14H12F2N4O3S
Ethyl 5-{[(4-bromo-1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4-cyano-3-methyl-2-thiophenecarboxylate chemical structure, C15H15BrN4O3S, CAS 515849-69-1
Ethyl 5-{[(4-bromo-1-ethyl-1H-pyrazol-3-yl)carbonyl]amino}-4-cyano-3-methyl-2-thiophenecarboxylate
CAS 515849-69-1C15H15BrN4O3S
Ethyl 5-[[3-cyano-5-(diethylcarbamoyl)-4-methylthiophen-2-yl]carbamoyl]-1-methylpyrazole-3-carboxylate chemical structure, C19H23N5O4S, CAS 496834-96-9
Ethyl 5-[[3-cyano-5-(diethylcarbamoyl)-4-methylthiophen-2-yl]carbamoyl]-1-methylpyrazole-3-carboxylate
CAS 496834-96-9C19H23N5O4S
N-(3-Carbamoyl-5-propan-2-ylthiophen-2-yl)-1-methyl-4-nitropyrazole-3-carboxamide chemical structure, C13H15N5O4S, CAS 512825-73-9
N-(3-Carbamoyl-5-propan-2-ylthiophen-2-yl)-1-methyl-4-nitropyrazole-3-carboxamide
CAS 512825-73-9C13H15N5O4S
N-(3-Carbamoyl-5-propan-2-ylthiophen-2-yl)-2,5-dimethyl-4-nitropyrazole-3-carboxamide chemical structure, C14H17N5O4S, CAS 1005575-57-4
N-(3-Carbamoyl-5-propan-2-ylthiophen-2-yl)-2,5-dimethyl-4-nitropyrazole-3-carboxamide
CAS 1005575-57-4C14H17N5O4S
Ethyl 4,5-dimethyl-2-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)thiophene-3-carboxylate chemical structure, C15H16F3N3O3S, CAS 1005616-68-1
Ethyl 4,5-dimethyl-2-({[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)thiophene-3-carboxylate
CAS 1005616-68-1C15H16F3N3O3S
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide chemical structure, C14H15F3N4O2S, CAS 1005662-88-3
N-(3-Carbamoyl-4-ethyl-5-methylthiophen-2-yl)-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
CAS 1005662-88-3C14H15F3N4O2S
Ethyl 2-{[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C14H16BrN3O3S, CAS 1005618-11-0
Ethyl 2-{[(4-bromo-1-methyl-1H-pyrazol-5-yl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 1005618-11-0C14H16BrN3O3S
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide chemical structure, C13H11F3N4OS, CAS 1005618-32-5
N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-methyl-5-(trifluoromethyl)pyrazole-3-carboxamide
CAS 1005618-32-5C13H11F3N4OS
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-4-iodo-1-methylpyrazole-3-carboxamide chemical structure, C12H13IN4O2S, CAS 1005633-64-6
N-(3-Carbamoyl-4,5-dimethylthiophen-2-yl)-4-iodo-1-methylpyrazole-3-carboxamide
CAS 1005633-64-6C12H13IN4O2S