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Murcko scaffold

Ring system with 3 rings and 19 atoms

397 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
397
With full pages
12
Scaffold SMILES

C(=Cc1nc(-c2ccccc2)cs1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1nc(-c2ccccc2)cs1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 397 chemicals

3-(2-Chlorophenyl)-3-oxo-2-(4-phenyl-2,3-dihydrothiazole-2-ylidene)-propionitrile chemical structure, C18H11ClN2OS, CAS 77768-58-2
3-(2-Chlorophenyl)-3-oxo-2-(4-phenyl-2,3-dihydrothiazole-2-ylidene)-propionitrile
CAS 77768-58-2C18H11ClN2OS
3-(2,4-Dichlorophenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C19H12Cl2N2OS, CAS 332056-05-0
3-(2,4-Dichlorophenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 332056-05-0C19H12Cl2N2OS
2-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-3-phenylprop-2-enenitrile chemical structure, C19H14N2S, CAS 277308-32-4
2-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-3-phenylprop-2-enenitrile
CAS 277308-32-4C19H14N2S
3-(4-Ethylphenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C21H18N2OS
3-(4-Ethylphenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
C21H18N2OS
Ethyl 2-[4-[2-cyano-2-(4-phenyl-2-thiazolyl)ethenyl]-2-methoxyphenoxy]acetate chemical structure, C23H20N2O4S, CAS 635698-31-6
Ethyl 2-[4-[2-cyano-2-(4-phenyl-2-thiazolyl)ethenyl]-2-methoxyphenoxy]acetate
CAS 635698-31-6C23H20N2O4S
(E)-3-(4-Chlorophenyl)-2-(4-phenylthiazol-2-yl)acrylonitrile chemical structure, C18H11ClN2S, CAS 72740-55-7
(E)-3-(4-Chlorophenyl)-2-(4-phenylthiazol-2-yl)acrylonitrile
CAS 72740-55-7C18H11ClN2S
(E)-3-(2-Nitrophenyl)-2-(4-(p-tolyl)thiazol-2-yl)acrylonitrile chemical structure, C19H13N3O2S, CAS 313687-04-6
(E)-3-(2-Nitrophenyl)-2-(4-(p-tolyl)thiazol-2-yl)acrylonitrile
CAS 313687-04-6C19H13N3O2S
(E)-3-(3-Nitrophenyl)-2-(4-phenylthiazol-2-yl)acrylonitrile chemical structure, C18H11N3O2S, CAS 313687-13-7
(E)-3-(3-Nitrophenyl)-2-(4-phenylthiazol-2-yl)acrylonitrile
CAS 313687-13-7C18H11N3O2S
(2E)-3-Phenyl-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile chemical structure, C18H12N2S, CAS 72740-58-0
(2E)-3-Phenyl-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile
CAS 72740-58-0C18H12N2S
(E)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(2-nitrophenyl)acrylonitrile chemical structure, C18H10ClN3O2S, CAS 313687-02-4
(E)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(2-nitrophenyl)acrylonitrile
CAS 313687-02-4C18H10ClN3O2S
3-(4-Methylphenyl)-2-(4-phenyl-1,3-thiazol-2-yl)acrylonitrile chemical structure, C19H14N2S, CAS 1321695-60-6
3-(4-Methylphenyl)-2-(4-phenyl-1,3-thiazol-2-yl)acrylonitrile
CAS 1321695-60-6C19H14N2S
(E)-3-(2-Chlorophenyl)-2-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C20H15ClN2S, CAS 5304-25-6
(E)-3-(2-Chlorophenyl)-2-[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 5304-25-6C20H15ClN2S
(E)-2-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-(2-ethoxyphenyl)prop-2-enenitrile chemical structure, C20H15BrN2OS, CAS 332052-03-6
(E)-2-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-(2-ethoxyphenyl)prop-2-enenitrile
CAS 332052-03-6C20H15BrN2OS
(2Z)-3-(4-Bromophenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C19H13BrN2OS, CAS 313686-23-6
(2Z)-3-(4-Bromophenyl)-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 313686-23-6C19H13BrN2OS
(E)-2-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(2-ethoxyphenyl)prop-2-enenitrile chemical structure, C20H14Cl2N2OS, CAS 5305-58-8
(E)-2-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(2-ethoxyphenyl)prop-2-enenitrile
CAS 5305-58-8C20H14Cl2N2OS
(E)-3-(3,5-Dichloro-2-methoxyphenyl)-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile chemical structure, C19H12Cl2N2OS, CAS 5309-21-7
(E)-3-(3,5-Dichloro-2-methoxyphenyl)-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile
CAS 5309-21-7C19H12Cl2N2OS
(E)-2-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)prop-2-enenitrile chemical structure, C19H12Cl2N2S, CAS 5310-50-9
(E)-2-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)prop-2-enenitrile
CAS 5310-50-9C19H12Cl2N2S
(E)-2-[4-(4-Ethoxyphenyl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)prop-2-enenitrile chemical structure, C21H18N2OS, CAS 313686-13-4
(E)-2-[4-(4-Ethoxyphenyl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)prop-2-enenitrile
CAS 313686-13-4C21H18N2OS
(2Z)-3-(4-Ethoxyphenyl)-2-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C20H15FN2OS, CAS 5319-47-1
(2Z)-3-(4-Ethoxyphenyl)-2-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 5319-47-1C20H15FN2OS
(E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(3-methoxyphenyl)prop-2-enenitrile chemical structure, C19H13ClN2OS, CAS 5346-87-2
(E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(3-methoxyphenyl)prop-2-enenitrile
CAS 5346-87-2C19H13ClN2OS
2-[4-(4-Butylphenyl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)acrylonitrile chemical structure, C23H22N2S, CAS 332175-17-4
2-[4-(4-Butylphenyl)-1,3-thiazol-2-yl]-3-(4-methylphenyl)acrylonitrile
CAS 332175-17-4C23H22N2S
(E)-3-(3,4-Dimethoxyphenyl)-2-(4-(4-methoxyphenyl)thiazol-2-yl)acrylonitrile chemical structure, C21H18N2O3S, CAS 313687-66-0
(E)-3-(3,4-Dimethoxyphenyl)-2-(4-(4-methoxyphenyl)thiazol-2-yl)acrylonitrile
CAS 313687-66-0C21H18N2O3S
(E)-3-(2,4-Dimethoxyphenyl)-2-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C22H20N2O4S, CAS 342593-25-3
(E)-3-(2,4-Dimethoxyphenyl)-2-[4-(3,4-dimethoxyphenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 342593-25-3C22H20N2O4S
(2E)-3-(2-Chlorophenyl)-2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile chemical structure, C18H9Cl3N2S, CAS 5212-27-1
(2E)-3-(2-Chlorophenyl)-2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]prop-2-enenitrile
CAS 5212-27-1C18H9Cl3N2S