CompoundList
Sign in
Murcko scaffold

1-Phenyl-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione scaffold

233 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
233
With full pages
60
Scaffold SMILES

O=C1CC(N2CCN(c3ccccc3)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(N2CCN(c3ccccc3)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 233 chemicals

1-(3-Chloro-4-methylphenyl)-3-[4-(3-methoxyphenyl)-1-piperazinyl]-2,5-pyrrolidinedione chemical structure, C22H24ClN3O3, CAS 488119-63-7
1-(3-Chloro-4-methylphenyl)-3-[4-(3-methoxyphenyl)-1-piperazinyl]-2,5-pyrrolidinedione
CAS 488119-63-7C22H24ClN3O3
3-[4-(4-Nitrophenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione chemical structure, C20H20N4O4, CAS 293766-09-3
3-[4-(4-Nitrophenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione
CAS 293766-09-3C20H20N4O4
1-(4-Methoxyphenyl)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrrolidine-2,5-dione chemical structure, C22H22F3N3O3, CAS 299408-97-2
1-(4-Methoxyphenyl)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrrolidine-2,5-dione
CAS 299408-97-2C22H22F3N3O3
1-(3-Chlorophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H19ClF3N3O2, CAS 299408-73-4
1-(3-Chlorophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-73-4C21H19ClF3N3O2
1-(4-Bromophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H19BrF3N3O2, CAS 299408-75-6
1-(4-Bromophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-75-6C21H19BrF3N3O2
1-(4-Chlorophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H19ClF3N3O2, CAS 299408-76-7
1-(4-Chlorophenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-76-7C21H19ClF3N3O2
1-(2-Methoxyphenyl)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrrolidine-2,5-dione chemical structure, C22H22F3N3O3, CAS 299408-98-3
1-(2-Methoxyphenyl)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrrolidine-2,5-dione
CAS 299408-98-3C22H22F3N3O3
1-(2,4-Dimethylphenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C23H24F3N3O2, CAS 306316-57-4
1-(2,4-Dimethylphenyl)-3-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyrrolidine-2,5-dione
CAS 306316-57-4C23H24F3N3O2
3-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C21H22FN3O3, CAS 299408-80-3
3-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 299408-80-3C21H22FN3O3
3-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(m-tolyl)pyrrolidine-2,5-dione chemical structure, C21H22FN3O2, CAS 296797-95-0
3-(4-(4-Fluorophenyl)piperazin-1-yl)-1-(m-tolyl)pyrrolidine-2,5-dione
CAS 296797-95-0C21H22FN3O2
1-(3-Chlorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H19ClFN3O2, CAS 5187-39-3
1-(3-Chlorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 5187-39-3C20H19ClFN3O2
1-(2,4-Dimethylphenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C22H24FN3O2, CAS 299408-95-0
1-(2,4-Dimethylphenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-95-0C22H24FN3O2
3-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(2-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C21H22FN3O3, CAS 299408-81-4
3-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(2-methoxyphenyl)pyrrolidine-2,5-dione
CAS 299408-81-4C21H22FN3O3
1-(3-Chlorophenyl)-3-[4-(4-chlorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H19Cl2N3O2, CAS 299408-59-6
1-(3-Chlorophenyl)-3-[4-(4-chlorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-59-6C20H19Cl2N3O2
1-(4-Bromophenyl)-3-[4-(4-chlorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H19BrClN3O2, CAS 299408-60-9
1-(4-Bromophenyl)-3-[4-(4-chlorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-60-9C20H19BrClN3O2
1-(4-Chlorophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H20ClN3O2, CAS 299408-64-3
1-(4-Chlorophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299408-64-3C20H20ClN3O2
1-(4-Bromophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H20BrN3O2, CAS 299408-65-4
1-(4-Bromophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299408-65-4C20H20BrN3O2
1-(2-Methoxyphenyl)-3-(4-phenyl-1-piperazinyl)-2,5-pyrrolidinedione chemical structure, C21H23N3O3, CAS 299408-66-5
1-(2-Methoxyphenyl)-3-(4-phenyl-1-piperazinyl)-2,5-pyrrolidinedione
CAS 299408-66-5C21H23N3O3
1-(3-Methylphenyl)-3-[4-(4-nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H22N4O4, CAS 299408-82-5
1-(3-Methylphenyl)-3-[4-(4-nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-82-5C21H22N4O4
1-(4-Methoxyphenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C21H23N3O3, CAS 299408-67-6
1-(4-Methoxyphenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299408-67-6C21H23N3O3
1-(2-Methoxyphenyl)-3-[4-(4-nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H22N4O5, CAS 299408-85-8
1-(2-Methoxyphenyl)-3-[4-(4-nitrophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-85-8C21H22N4O5
1-(3-Chlorophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H20ClN3O2, CAS 299408-68-7
1-(3-Chlorophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299408-68-7C20H20ClN3O2
1-(3,4-Dichlorophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H19Cl2N3O2, CAS 299408-69-8
1-(3,4-Dichlorophenyl)-3-(4-phenylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299408-69-8C20H19Cl2N3O2
1-(3,4-Dichlorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H18Cl2FN3O2, CAS 299408-88-1
1-(3,4-Dichlorophenyl)-3-[4-(4-fluorophenyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299408-88-1C20H18Cl2FN3O2