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Murcko scaffold

1-Phenyl-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione scaffold

25 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
25
With full pages
11
Scaffold SMILES

O=C1CC(N2CCN(c3ccccn3)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(N2CCN(c3ccccn3)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

1-(4-Fluorophenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H19FN4O2, CAS 299949-40-9
1-(4-Fluorophenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299949-40-9C19H19FN4O2
1-(4-Methoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H22N4O3, CAS 296800-60-7
1-(4-Methoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 296800-60-7C20H22N4O3
1-(2-Methoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H22N4O3, CAS 313378-61-9
1-(2-Methoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 313378-61-9C20H22N4O3
1-Phenyl-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H20N4O2, CAS 296801-18-8
1-Phenyl-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 296801-18-8C19H20N4O2
1-(4-Chlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C19H19ClN4O2, CAS 299949-58-9
1-(4-Chlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 299949-58-9C19H19ClN4O2
1-(3-Chlorophenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H19ClN4O2, CAS 299949-59-0
1-(3-Chlorophenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 299949-59-0C19H19ClN4O2
1-(3-Methylphenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H22N4O2, CAS 296769-62-5
1-(3-Methylphenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 296769-62-5C20H22N4O2
1-(4-Hexoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C25H32N4O3, CAS 333398-61-1
1-(4-Hexoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 333398-61-1C25H32N4O3
1-(3-Methoxyphenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H22N4O3, CAS 333398-37-1
1-(3-Methoxyphenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 333398-37-1C20H22N4O3
1-(3,5-Dichlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C19H18Cl2N4O2, CAS 333398-85-9
1-(3,5-Dichlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 333398-85-9C19H18Cl2N4O2
1-(4-Propoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C22H26N4O3, CAS 296769-73-8
1-(4-Propoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 296769-73-8C22H26N4O3
1-(3,4-Dichlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C19H18Cl2N4O2, CAS 331759-48-9
1-(3,4-Dichlorophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 331759-48-9C19H18Cl2N4O2
1-(3-Bromophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C19H19BrN4O2, CAS 311776-49-5
1-(3-Bromophenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 311776-49-5C19H19BrN4O2
Methyl 4-[2,5-dioxo-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]benzoate chemical structure, C21H22N4O4, CAS 313400-33-8
Methyl 4-[2,5-dioxo-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]benzoate
CAS 313400-33-8C21H22N4O4
1-(3-Ethoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C21H24N4O3, CAS 313380-86-8
1-(3-Ethoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 313380-86-8C21H24N4O3
1-(4-Butoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C23H28N4O3, CAS 312504-82-8
1-(4-Butoxyphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 312504-82-8C23H28N4O3
1-(4-Ethoxyphenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H24N4O3, CAS 331966-23-5
1-(4-Ethoxyphenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 331966-23-5C21H24N4O3
1-(2-Fluorophenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C19H19FN4O2, CAS 332125-89-0
1-(2-Fluorophenyl)-3-[4-(pyridin-2-yl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 332125-89-0C19H19FN4O2
1-(3-Chloro-4-methylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H21ClN4O2, CAS 330865-11-7
1-(3-Chloro-4-methylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 330865-11-7C20H21ClN4O2
Ethyl 4-[2,5-dioxo-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]benzoate chemical structure, C22H24N4O4, CAS 330864-95-4
Ethyl 4-[2,5-dioxo-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]benzoate
CAS 330864-95-4C22H24N4O4
1-(4-Acetylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C21H22N4O3, CAS 6043-64-7
1-(4-Acetylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 6043-64-7C21H22N4O3
1-(4-Methylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione chemical structure, C20H22N4O2, CAS 317324-79-1
1-(4-Methylphenyl)-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidine-2,5-dione
CAS 317324-79-1C20H22N4O2
Butyl 4-[2,5-dioxo-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]benzoate chemical structure, C24H28N4O4, CAS 361999-86-2
Butyl 4-[2,5-dioxo-3-(4-pyridin-2-ylpiperazin-1-yl)pyrrolidin-1-yl]benzoate
CAS 361999-86-2C24H28N4O4
3-(4-Pyridin-2-ylpiperazin-1-yl)-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione chemical structure, C20H19F3N4O2, CAS 590378-37-3
3-(4-Pyridin-2-ylpiperazin-1-yl)-1-[4-(trifluoromethyl)phenyl]pyrrolidine-2,5-dione
CAS 590378-37-3C20H19F3N4O2