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Murcko scaffold

Ring system with 4 rings and 25 atoms

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
18
With full pages
4
Scaffold SMILES

O=C1CC(N2CCC(N3CCCCC3)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(N2CCC(N3CCCCC3)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

1-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H27FN4O3, CAS 309731-39-3
1-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 309731-39-3C21H27FN4O3
1-[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H27ClN4O3, CAS 381185-71-3
1-[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 381185-71-3C21H27ClN4O3
1-[2,5-Dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C24H34N4O4, CAS 381185-67-7
1-[2,5-Dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 381185-67-7C24H34N4O4
Ethyl 4-[3-(4-carbamoyl-4-piperidin-1-ylpiperidin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C24H32N4O5, CAS 381185-69-9
Ethyl 4-[3-(4-carbamoyl-4-piperidin-1-ylpiperidin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 381185-69-9C24H32N4O5
1-[1-(3,4-Dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H26Cl2N4O3, CAS 381185-91-7
1-[1-(3,4-Dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 381185-91-7C21H26Cl2N4O3
1-[1-(3-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C23H32N4O4, CAS 309921-90-2
1-[1-(3-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 309921-90-2C23H32N4O4
1-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C23H32N4O4, CAS 381185-87-1
1-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 381185-87-1C23H32N4O4
1-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H27BrN4O3, CAS 381185-13-3
1-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 381185-13-3C21H27BrN4O3
1-[2,5-Dioxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C22H27F3N4O3, CAS 522638-07-9
1-[2,5-Dioxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 522638-07-9C22H27F3N4O3
Butyl 4-(3-(4'-carbamoyl-[1,4'-bipiperidin]-1'-yl)-2,5-dioxopyrrolidin-1-yl)benzoate chemical structure, C26H36N4O5, CAS 361999-24-8
Butyl 4-(3-(4'-carbamoyl-[1,4'-bipiperidin]-1'-yl)-2,5-dioxopyrrolidin-1-yl)benzoate
CAS 361999-24-8C26H36N4O5
1-[1-(2-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C22H30N4O4, CAS 361995-57-5
1-[1-(2-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 361995-57-5C22H30N4O4
1-[1-(2-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H27FN4O3, CAS 350708-05-3
1-[1-(2-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 350708-05-3C21H27FN4O3
1-[1-(3-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H27BrN4O3, CAS 350708-02-0
1-[1-(3-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 350708-02-0C21H27BrN4O3
1-[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C21H27ClN4O3, CAS 350708-10-0
1-[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 350708-10-0C21H27ClN4O3
1-[1-(3-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C22H30N4O4, CAS 361374-64-3
1-[1-(3-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 361374-64-3C22H30N4O4
Methyl 4-[3-(4-carbamoyl-4-piperidin-1-ylpiperidin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C23H30N4O5, CAS 350708-03-1
Methyl 4-[3-(4-carbamoyl-4-piperidin-1-ylpiperidin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 350708-03-1C23H30N4O5
1-[1-[4-Chloro-3-(trifluoromethyl)phenyl]-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C22H26ClF3N4O3, CAS 587849-79-4
1-[1-[4-Chloro-3-(trifluoromethyl)phenyl]-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 587849-79-4C22H26ClF3N4O3
1-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide chemical structure, C22H30N4O4, CAS 309731-40-6
1-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-piperidin-1-ylpiperidine-4-carboxamide
CAS 309731-40-6C22H30N4O4