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Murcko scaffold

Ring system with 4 rings and 23 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
8
With full pages
4
Scaffold SMILES

c1ccc(-c2cc(C3CCN(c4ccccc4)CC3)[nH]n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cc(C3CCN(c4ccccc4)CC3)[nH]n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-4-[5-(3-nitrophenyl)-1H-pyrazol-3-yl]piperidine chemical structure, C21H17F3N6O6, CAS 1025769-22-5
1-[2,6-Dinitro-4-(trifluoromethyl)phenyl]-4-[5-(3-nitrophenyl)-1H-pyrazol-3-yl]piperidine
CAS 1025769-22-5C21H17F3N6O6
1-(4-{4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]piperidino}-3-nitrophenyl)-1-ethanone chemical structure, C22H21ClN4O3, CAS 1030856-24-6
1-(4-{4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]piperidino}-3-nitrophenyl)-1-ethanone
CAS 1030856-24-6C22H21ClN4O3
1-(4-{4-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]piperidino}-3-nitrophenyl)-1-ethanone chemical structure, C23H24N4O4, CAS 1026092-88-5
1-(4-{4-[5-(4-Methoxyphenyl)-1H-pyrazol-3-yl]piperidino}-3-nitrophenyl)-1-ethanone
CAS 1026092-88-5C23H24N4O4
1-(4-{4-[5-(2,4-Dichlorophenyl)-1H-pyrazol-3-yl]piperidino}-3-nitrophenyl)-1-ethanone chemical structure, C22H20Cl2N4O3, CAS 1026078-87-4
1-(4-{4-[5-(2,4-Dichlorophenyl)-1H-pyrazol-3-yl]piperidino}-3-nitrophenyl)-1-ethanone
CAS 1026078-87-4C22H20Cl2N4O3
4-[4-[3-(4-Methoxyphenyl)-1H-pyrazol-5-yl]-1-piperidinyl]-3-nitrobenzoic acid methyl ester chemical structure, C23H24N4O5, CAS 1026093-45-7
4-[4-[3-(4-Methoxyphenyl)-1H-pyrazol-5-yl]-1-piperidinyl]-3-nitrobenzoic acid methyl ester
CAS 1026093-45-7C23H24N4O5
4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-1-[2,6-dinitro-4-(trifluoromethyl)phenyl]piperidine chemical structure, C21H17ClF3N5O4, CAS 1026080-33-0
4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-1-[2,6-dinitro-4-(trifluoromethyl)phenyl]piperidine
CAS 1026080-33-0C21H17ClF3N5O4
Methyl 4-[4-[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]piperidin-1-yl]benzoate chemical structure, C22H21Cl2N3O2, CAS 1026095-65-7
Methyl 4-[4-[3-(2,4-dichlorophenyl)-1H-pyrazol-5-yl]piperidin-1-yl]benzoate
CAS 1026095-65-7C22H21Cl2N3O2
1-[4-Nitro-3-(trifluoromethyl)phenyl]-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine chemical structure, C22H18F6N4O2, CAS 1026780-29-9
1-[4-Nitro-3-(trifluoromethyl)phenyl]-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine
CAS 1026780-29-9C22H18F6N4O2