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Murcko scaffold

Ring system with 4 rings and 23 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
7
With full pages
5
Scaffold SMILES

c1ccc(-c2cc(C3CCN(c4ccccn4)CC3)[nH]n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cc(C3CCN(c4ccccn4)CC3)[nH]n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

2-[4-[3-(3-Nitrophenyl)-1H-pyrazol-5-yl]piperidin-1-yl]pyridine-3-carbonitrile chemical structure, C20H18N6O2, CAS 1030386-17-4
2-[4-[3-(3-Nitrophenyl)-1H-pyrazol-5-yl]piperidin-1-yl]pyridine-3-carbonitrile
CAS 1030386-17-4C20H18N6O2
2-[4-[3-(2,5-Dimethoxyphenyl)-1H-pyrazol-5-yl]piperidin-1-yl]-3-nitropyridine chemical structure, C21H23N5O4, CAS 1026077-65-5
2-[4-[3-(2,5-Dimethoxyphenyl)-1H-pyrazol-5-yl]piperidin-1-yl]-3-nitropyridine
CAS 1026077-65-5C21H23N5O4
4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-1-(3-nitro-2-pyridinyl)piperidine chemical structure, C19H18ClN5O2, CAS 1030856-25-7
4-[5-(4-Chlorophenyl)-1H-pyrazol-3-yl]-1-(3-nitro-2-pyridinyl)piperidine
CAS 1030856-25-7C19H18ClN5O2
4-[5-(2,4-Dichlorophenyl)-1H-pyrazol-3-yl]-1-(3-nitro-2-pyridinyl)piperidine chemical structure, C19H17Cl2N5O2, CAS 1024018-46-9
4-[5-(2,4-Dichlorophenyl)-1H-pyrazol-3-yl]-1-(3-nitro-2-pyridinyl)piperidine
CAS 1024018-46-9C19H17Cl2N5O2
Methyl 4-{3-[1-(3-nitro-2-pyridinyl)-4-piperidinyl]-1H-pyrazol-5-yl}phenyl ether chemical structure, C20H21N5O3, CAS 1031208-10-2
Methyl 4-{3-[1-(3-nitro-2-pyridinyl)-4-piperidinyl]-1H-pyrazol-5-yl}phenyl ether
CAS 1031208-10-2C20H21N5O3
1-(3-Nitro-2-pyridinyl)-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine chemical structure, C20H18F3N5O2, CAS 1026081-31-1
1-(3-Nitro-2-pyridinyl)-4-{5-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-yl}piperidine
CAS 1026081-31-1C20H18F3N5O2
3-Chloro-2-{4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidin-1-yl}-5-(trifluoromethyl)pyridine chemical structure, C20H17Cl2F3N4, CAS 321848-27-5
3-Chloro-2-{4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidin-1-yl}-5-(trifluoromethyl)pyridine
CAS 321848-27-5C20H17Cl2F3N4