Murcko scaffold
Ring system with 2 rings and 18 atoms
81 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 18
- Chemicals
- 81
- With full pages
- 11
Scaffold SMILES
O=C(COC(=O)c1cccs1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 81 of 81 chemicals
![[(3-Methoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C15H15NO4S, CAS 387854-74-2](/s/FOLLNTRVVYCEOE-UHFFFAOYSA-N.svg)
[(3-Methoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 387854-74-2C15H15NO4S
![[2-(3-Methylanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C15H15NO3S, CAS 387854-76-4](/s/RPMHSCWSYKBQAY-UHFFFAOYSA-N.svg)
[2-(3-Methylanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387854-76-4C15H15NO3S
![[(2-Methoxy-5-methylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C16H17NO4S, CAS 387854-78-6](/s/QJSHNLIPSPAPAW-UHFFFAOYSA-N.svg)
[(2-Methoxy-5-methylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 387854-78-6C16H17NO4S
![[2-(2-Chloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H12ClNO3S, CAS 387854-85-5](/s/JNXVIVHZCRCJTP-UHFFFAOYSA-N.svg)
[2-(2-Chloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387854-85-5C14H12ClNO3S
![[(2-Methylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C15H15NO3S, CAS 387854-98-0](/s/JXFRJHITZQUWRO-UHFFFAOYSA-N.svg)
[(2-Methylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 387854-98-0C15H15NO3S
![[2-[4-(Dimethylamino)anilino]-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C16H18N2O3S, CAS 387855-20-1](/s/UOIGYWHZDDAMEU-UHFFFAOYSA-N.svg)
[2-[4-(Dimethylamino)anilino]-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387855-20-1C16H18N2O3S
![[2-(2,4-Difluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H11F2NO3S, CAS 387855-22-3](/s/YCPCIRMHNCGGSM-UHFFFAOYSA-N.svg)
[2-(2,4-Difluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387855-22-3C14H11F2NO3S
![[2-(2-Chloro-4-fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H11ClFNO3S, CAS 387855-32-5](/s/LYYVERYYTWDQTR-UHFFFAOYSA-N.svg)
[2-(2-Chloro-4-fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387855-32-5C14H11ClFNO3S
![[2-(2,6-Difluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H11F2NO3S, CAS 387855-45-0](/s/MUDJFHWVULTPES-UHFFFAOYSA-N.svg)
[2-(2,6-Difluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387855-45-0C14H11F2NO3S
![[(2-Ethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C16H17NO4S, CAS 387855-49-4](/s/KHJKERNMMVYYPP-UHFFFAOYSA-N.svg)
[(2-Ethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 387855-49-4C16H17NO4S
(2-Anilino-2-oxoethyl) 5-methylthiophene-2-carboxylate
CAS 1004161-08-3C14H13NO3S
![[2-(4-Fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H12FNO3S, CAS 387856-11-3](/s/RYVPTUSQRNBYCJ-UHFFFAOYSA-N.svg)
[2-(4-Fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387856-11-3C14H12FNO3S
![[2-(3-Chloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H12ClNO3S, CAS 387860-00-6](/s/NQZHLRCNYARLRE-UHFFFAOYSA-N.svg)
[2-(3-Chloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387860-00-6C14H12ClNO3S
![[2-(4-Ethylanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C16H17NO3S, CAS 387860-04-0](/s/XODNHFUIOWKDMS-UHFFFAOYSA-N.svg)
[2-(4-Ethylanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387860-04-0C16H17NO3S
![[(2-Methoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C15H15NO4S, CAS 876536-16-2](/s/JDWUWSGDRUSFTP-UHFFFAOYSA-N.svg)
[(2-Methoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 876536-16-2C15H15NO4S
![[2-(4-Chloro-2-fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H11ClFNO3S, CAS 488750-77-2](/s/ZGSQPGNXMAQMKI-UHFFFAOYSA-N.svg)
[2-(4-Chloro-2-fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 488750-77-2C14H11ClFNO3S
![[2-(4-Chloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H12ClNO3S, CAS 939158-98-2](/s/LLUXCGVBIYKECY-UHFFFAOYSA-N.svg)
[2-(4-Chloroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 939158-98-2C14H12ClNO3S
![[(3,4-Dimethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C16H17NO5S, CAS 479610-81-6](/s/SUWNTOAWSBNUIO-UHFFFAOYSA-N.svg)
[(3,4-Dimethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 479610-81-6C16H17NO5S
![[2-(4-Ethoxyanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C16H17NO4S, CAS 474663-44-0](/s/FIBKMRPFTWZMJJ-UHFFFAOYSA-N.svg)
[2-(4-Ethoxyanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 474663-44-0C16H17NO4S
![[2-(2-Fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C14H12FNO3S, CAS 876536-28-6](/s/NIIDLQZPISLYMV-UHFFFAOYSA-N.svg)
[2-(2-Fluoroanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 876536-28-6C14H12FNO3S
![[2-Oxo-2-(3,4,5-trimethoxyanilino)ethyl] 5-nitrothiophene-2-carboxylate chemical structure, C16H16N2O8S, CAS 853355-56-3](/s/BAPYSLMQUITPOO-UHFFFAOYSA-N.svg)
[2-Oxo-2-(3,4,5-trimethoxyanilino)ethyl] 5-nitrothiophene-2-carboxylate
CAS 853355-56-3C16H16N2O8S
![[2-(3-Chloro-4-methoxyanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate chemical structure, C15H14ClNO4S, CAS 387855-51-8](/s/LRBUCHPQGHGMAO-UHFFFAOYSA-N.svg)
[2-(3-Chloro-4-methoxyanilino)-2-oxoethyl] 5-methylthiophene-2-carboxylate
CAS 387855-51-8C15H14ClNO4S
![[(3,5-Dimethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C16H17NO5S, CAS 438014-02-9](/s/VUCBHQMPDOOQNI-UHFFFAOYSA-N.svg)
[(3,5-Dimethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 438014-02-9C16H17NO5S
![[2-(3,4-Difluoroanilino)-2-oxoethyl] thiophene-2-carboxylate chemical structure, C13H9F2NO3S, CAS 391263-78-8](/s/GKJKGLWMZGXRJV-UHFFFAOYSA-N.svg)
[2-(3,4-Difluoroanilino)-2-oxoethyl] thiophene-2-carboxylate
CAS 391263-78-8C13H9F2NO3S
- [2-(2-Nitroanilino)-2-oxoethyl] thiophene-2-carboxylate473896-67-2C13H10N2O5S
- [2-(4-Methoxycarbonylanilino)-2-oxoethyl] 3-methylthiophene-2-carboxylate1002011-12-2C16H15NO5S
- [2-(2-Ethylanilino)-2-oxoethyl] 3-methylthiophene-2-carboxylate1003285-77-5C16H17NO3S
- 2-((5-Chloro-2,4-dimethoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate1241986-06-0C16H16ClNO5S
- [(5-Chloro-2,4-dimethoxyphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate1241157-85-6C16H16ClNO5S
- 2-(Ethyl(phenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate1241967-21-4C16H17NO3S
- 2-((2-Chloro-5-fluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate1241982-51-3C14H11ClFNO3S
- [(2-Chloro-5-fluorophenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate1794884-16-4C14H11ClFNO3S
- 2-(Ethyl(phenyl)amino)-2-oxoethyl 5-methylthiophene-2-carboxylate1794845-17-2C16H17NO3S
Related scaffolds
Same ring framework with different atoms or bond orders
C(=CC1CCCC1)CCOc1ccccc137 chemicals
O=C(NCCCn1ccnc1)c1ccccc122 chemicals
O=S(=O)(NCCCn1ccnc1)c1ccccc120 chemicals
O=C(COC(=O)c1ccccc1)NC1CCCC117 chemicals
O=C(COc1ccccc1)NCC1CCCO117 chemicals
S=C(NCCc1ccccc1)Nc1nccs116 chemicals
O=C(CCS(=O)(=O)c1ccccc1)Nc1cccs113 chemicals![Scaffold O=C(CSc1ncn[nH]1)NCc1ccccc1](/scaffold/ZBSYLOJDGBMFAD-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncn[nH]1)NCc1ccccc113 chemicals
O=C(Cn1cccn1)NN=Cc1ccccc112 chemicals
O=C(NCC1CCCO1)C(=O)Nc1ccccc112 chemicals![Scaffold O=C(Cc1ccc[nH]1)NN=Cc1ccccc1](/scaffold/XCXHYNVYLRCCIP-UHFFFAOYSA-N/structure.svg)
O=C(Cc1ccc[nH]1)NN=Cc1ccccc112 chemicals![Scaffold O=C(NNC(=S)Nc1ccccc1)c1cc[nH]n1](/scaffold/GFTUZBZNWRQYBL-UHFFFAOYSA-N/structure.svg)
O=C(NNC(=S)Nc1ccccc1)c1cc[nH]n111 chemicals