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Murcko scaffold

Ring system with 2 rings and 18 atoms

81 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
81
With full pages
11
Scaffold SMILES

O=C(COC(=O)c1cccs1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)c1cccs1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 81 chemicals

Thiophene-2-carboxylic acid (4-ethyl-phenylcarbamoyl)-methyl ester chemical structure, C15H15NO3S, CAS 391264-25-8
Thiophene-2-carboxylic acid (4-ethyl-phenylcarbamoyl)-methyl ester
CAS 391264-25-8C15H15NO3S
[2-(2-Chloroanilino)-2-oxoethyl] thiophene-2-carboxylate chemical structure, C13H10ClNO3S, CAS 391263-70-0
[2-(2-Chloroanilino)-2-oxoethyl] thiophene-2-carboxylate
CAS 391263-70-0C13H10ClNO3S
[2-Oxo-2-[2-(trifluoromethyl)anilino]ethyl] thiophene-2-carboxylate chemical structure, C14H10F3NO3S, CAS 692757-64-5
[2-Oxo-2-[2-(trifluoromethyl)anilino]ethyl] thiophene-2-carboxylate
CAS 692757-64-5C14H10F3NO3S
[2-(3-Chloroanilino)-2-oxoethyl] thiophene-2-carboxylate chemical structure, C13H10ClNO3S, CAS 391264-22-5
[2-(3-Chloroanilino)-2-oxoethyl] thiophene-2-carboxylate
CAS 391264-22-5C13H10ClNO3S
[2-(3-Chloro-4-methylanilino)-2-oxoethyl] thiophene-2-carboxylate chemical structure, C14H12ClNO3S, CAS 391263-77-7
[2-(3-Chloro-4-methylanilino)-2-oxoethyl] thiophene-2-carboxylate
CAS 391263-77-7C14H12ClNO3S
[2-(2-Methoxyanilino)-2-oxoethyl] 5-nitrothiophene-2-carboxylate chemical structure, C14H12N2O6S, CAS 744234-78-4
[2-(2-Methoxyanilino)-2-oxoethyl] 5-nitrothiophene-2-carboxylate
CAS 744234-78-4C14H12N2O6S
[(2,6-Dimethylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C16H17NO3S, CAS 380166-60-9
[(2,6-Dimethylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 380166-60-9C16H17NO3S
2-((3-Methoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C15H15NO4S, CAS 380567-25-9
2-((3-Methoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 380567-25-9C15H15NO4S
2-Oxo-2-(phenylamino)ethyl 3-methylthiophene-2-carboxylate chemical structure, C14H13NO3S, CAS 380567-83-9
2-Oxo-2-(phenylamino)ethyl 3-methylthiophene-2-carboxylate
CAS 380567-83-9C14H13NO3S
2-((2,3-Dimethylphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C16H17NO3S, CAS 380336-01-6
2-((2,3-Dimethylphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 380336-01-6C16H17NO3S
[(2,5-Difluorophenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C14H11F2NO3S, CAS 438606-35-0
[(2,5-Difluorophenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 438606-35-0C14H11F2NO3S
2-((2,5-Difluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C14H11F2NO3S, CAS 438606-32-7
2-((2,5-Difluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 438606-32-7C14H11F2NO3S
2-((3-Chloro-4-methoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C15H14ClNO4S, CAS 387853-87-4
2-((3-Chloro-4-methoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 387853-87-4C15H14ClNO4S
[Methyl(phenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C15H15NO3S, CAS 387854-49-1
[Methyl(phenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 387854-49-1C15H15NO3S
2-((4-Ethoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C16H17NO4S, CAS 474376-12-0
2-((4-Ethoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 474376-12-0C16H17NO4S
2-((2-Methoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C15H15NO4S, CAS 721901-70-8
2-((2-Methoxyphenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 721901-70-8C15H15NO4S
[2-(2-Cyanoanilino)-2-oxoethyl] thiophene-2-carboxylate chemical structure, C14H10N2O3S, CAS 391263-72-2
[2-(2-Cyanoanilino)-2-oxoethyl] thiophene-2-carboxylate
CAS 391263-72-2C14H10N2O3S
2-[[4-(Acetylamino)phenyl]amino]-2-oxoethyl 5-methyl-2-thiophenecarboxylate chemical structure, C16H16N2O4S, CAS 438012-43-2
2-[[4-(Acetylamino)phenyl]amino]-2-oxoethyl 5-methyl-2-thiophenecarboxylate
CAS 438012-43-2C16H16N2O4S
2-(Methyl(phenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C15H15NO3S, CAS 387853-38-5
2-(Methyl(phenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 387853-38-5C15H15NO3S
2-((2-Fluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C14H12FNO3S, CAS 479717-93-6
2-((2-Fluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 479717-93-6C14H12FNO3S
{[2-(Methoxycarbonyl)phenyl]carbamoyl}methyl 5-methylthiophene-2-carboxylate chemical structure, C16H15NO5S, CAS 721913-39-9
{[2-(Methoxycarbonyl)phenyl]carbamoyl}methyl 5-methylthiophene-2-carboxylate
CAS 721913-39-9C16H15NO5S
2-((4-Fluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C14H12FNO3S, CAS 387854-15-1
2-((4-Fluorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 387854-15-1C14H12FNO3S
[(4-Methylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate chemical structure, C15H15NO3S, CAS 387855-01-8
[(4-Methylphenyl)carbamoyl]methyl 5-methylthiophene-2-carboxylate
CAS 387855-01-8C15H15NO3S
2-((2-Chlorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate chemical structure, C14H12ClNO3S, CAS 387853-57-8
2-((2-Chlorophenyl)amino)-2-oxoethyl 3-methylthiophene-2-carboxylate
CAS 387853-57-8C14H12ClNO3S