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Murcko scaffold

Ring system with 3 rings and 21 atoms

6 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 21
Chemicals: 6
With full pages: 5

Scaffold SMILES

O=C(NCc1ccccc1)C1Oc2ccccc2NC1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCc1ccccc1)C1Oc2ccccc2NC1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 6 of 6 chemicals

N-Benzyl-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide chemical structure, C17H16N2O3, CAS 861211-64-5

N-Benzyl-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

CAS 861211-64-5C₁₇H₁₆N₂O₃

2-Methyl-N-(4-methylbenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide chemical structure, C18H18N2O3, CAS 861211-46-3

2-Methyl-N-(4-methylbenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

CAS 861211-46-3C₁₈H₁₈N₂O₃

Methyl 2-{[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]amino}-2-phenylacetate chemical structure, C19H18N2O5, CAS 1008710-08-4

Methyl 2-{[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]amino}-2-phenylacetate

CAS 1008710-08-4C₁₉H₁₈N₂O₅

N-(4-Fluorobenzyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide chemical structure, C17H15FN2O3, CAS 861208-00-6

N-(4-Fluorobenzyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

CAS 861208-00-6C₁₇H₁₅FN₂O₃

N-(3,4-Dichlorobenzyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide chemical structure, C17H14Cl2N2O3, CAS 861211-45-2

N-(3,4-Dichlorobenzyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

CAS 861211-45-2C₁₇H₁₄Cl₂N₂O₃

N-(3-Methoxybenzyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide chemical structure, C18H18N2O4, CAS 860786-79-4

N-(3-Methoxybenzyl)-2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxamide

CAS 860786-79-4C₁₈H₁₈N₂O₄