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Murcko scaffold

Ring system with 2 rings and 13 atoms

53 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
53
With full pages
6
Scaffold SMILES

C=C1N=C(c2ccccc2)OC1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C=C1N=C(c2ccccc2)OC1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

4-Isopropylidene-2-phenyl-5(4H)-oxazole chemical structure, C12H11NO2, CAS 4491-47-8
4-Isopropylidene-2-phenyl-5(4H)-oxazole
CAS 4491-47-8C12H11NO2
2-(5-Oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)propane-1,3-diyl diacetate chemical structure, C16H15NO6, CAS 92964-25-5
2-(5-Oxo-2-phenyl-1,3-oxazol-4(5H)-ylidene)propane-1,3-diyl diacetate
CAS 92964-25-5C16H15NO6
5(4H)-Oxazolone, 4-ethylidene-2-phenyl- chemical structure, C11H9NO2, CAS 37791-41-6
5(4H)-Oxazolone, 4-ethylidene-2-phenyl-
CAS 37791-41-6C11H9NO2
GNF-Pf-562 chemical structure, C10H5Cl2NO2, CAS 54902-24-8
GNF-Pf-562
CAS 54902-24-8C10H5Cl2NO2
(4Z)-2-(2,4-Dichlorophenyl)-4-[(dimethylamino)methylidene]-1,3-oxazol-5(4H)-one chemical structure, C12H10Cl2N2O2, CAS 1164542-47-5
(4Z)-2-(2,4-Dichlorophenyl)-4-[(dimethylamino)methylidene]-1,3-oxazol-5(4H)-one
CAS 1164542-47-5C12H10Cl2N2O2
4-[(Dimethylamino)methylene]-2-phenyl-1,3-oxazol-5(4H)-one chemical structure, C12H12N2O2
4-[(Dimethylamino)methylene]-2-phenyl-1,3-oxazol-5(4H)-one
C12H12N2O2
(4Z)-4-[(Dimethylamino)methylene]-2-phenyl-1,3-oxazol-5(4H)-one chemical structure, C12H12N2O2, CAS 51254-00-3
(4Z)-4-[(Dimethylamino)methylene]-2-phenyl-1,3-oxazol-5(4H)-one
CAS 51254-00-3C12H12N2O2
(4Z)-2-(3-Bromophenyl)-4-(dimethylaminomethylidene)-1,3-oxazol-5-one chemical structure, C12H11BrN2O2, CAS 313479-93-5
(4Z)-2-(3-Bromophenyl)-4-(dimethylaminomethylidene)-1,3-oxazol-5-one
CAS 313479-93-5C12H11BrN2O2
(4Z)-4-(Dimethylaminomethylidene)-2-(3-fluorophenyl)-1,3-oxazol-5-one chemical structure, C12H11FN2O2, CAS 313401-99-9
(4Z)-4-(Dimethylaminomethylidene)-2-(3-fluorophenyl)-1,3-oxazol-5-one
CAS 313401-99-9C12H11FN2O2
(4Z)-2-(2-Bromophenyl)-4-[(dimethylamino)methylidene]-1,3-oxazol-5(4H)-one chemical structure, C12H11BrN2O2, CAS 353763-08-3
(4Z)-2-(2-Bromophenyl)-4-[(dimethylamino)methylidene]-1,3-oxazol-5(4H)-one
CAS 353763-08-3C12H11BrN2O2
2-(2-Chlorophenyl)-4-[(dimethylamino)methylene]-1,3-oxazol-5(4H)-one chemical structure, C12H11ClN2O2, CAS 173345-06-7
2-(2-Chlorophenyl)-4-[(dimethylamino)methylene]-1,3-oxazol-5(4H)-one
CAS 173345-06-7C12H11ClN2O2
(4Z)-4-[(Dimethylamino)methylidene]-2-(4-nitrophenyl)-1,3-oxazol-5(4H)-one chemical structure, C12H11N3O4, CAS 154821-63-3
(4Z)-4-[(Dimethylamino)methylidene]-2-(4-nitrophenyl)-1,3-oxazol-5(4H)-one
CAS 154821-63-3C12H11N3O4
(4E)-4-(Dimethylaminomethylidene)-2-(4-methoxyphenyl)-1,3-oxazol-5-one chemical structure, C13H14N2O3, CAS 154821-61-1
(4E)-4-(Dimethylaminomethylidene)-2-(4-methoxyphenyl)-1,3-oxazol-5-one
CAS 154821-61-1C13H14N2O3
(4Z)-4-(Dimethylaminomethylidene)-2-(2-fluorophenyl)-1,3-oxazol-5-one chemical structure, C12H11FN2O2, CAS 353763-13-0
(4Z)-4-(Dimethylaminomethylidene)-2-(2-fluorophenyl)-1,3-oxazol-5-one
CAS 353763-13-0C12H11FN2O2
4-[(E)-(Dimethylamino)methylidene]-2-(4-fluorophenyl)-1,3-oxazol-5(4H)-one chemical structure, C12H11FN2O2, CAS 371220-46-1
4-[(E)-(Dimethylamino)methylidene]-2-(4-fluorophenyl)-1,3-oxazol-5(4H)-one
CAS 371220-46-1C12H11FN2O2
2-(3-Chlorophenyl)-4-((dimethylamino)methylene)oxazol-5(4H)-one chemical structure, C12H11ClN2O2
2-(3-Chlorophenyl)-4-((dimethylamino)methylene)oxazol-5(4H)-one
C12H11ClN2O2
(4Z)-2-(3-Chlorophenyl)-4-(dimethylaminomethylidene)-1,3-oxazol-5-one chemical structure, C12H11ClN2O2, CAS 373618-95-2
(4Z)-2-(3-Chlorophenyl)-4-(dimethylaminomethylidene)-1,3-oxazol-5-one
CAS 373618-95-2C12H11ClN2O2
5(4H)-Oxazolone, 4-(dichloromethylene)-2-(4-methylphenyl)- chemical structure, C11H7Cl2NO2, CAS 61767-34-8
5(4H)-Oxazolone, 4-(dichloromethylene)-2-(4-methylphenyl)-
CAS 61767-34-8C11H7Cl2NO2
(e)-4-((Dimethylamino)methylene)-2-(p-tolyl)oxazol-5(4H)-one chemical structure, C13H14N2O2
(e)-4-((Dimethylamino)methylene)-2-(p-tolyl)oxazol-5(4H)-one
C13H14N2O2
(E)-4-(Ethoxymethylene)-2-phenyloxazol-5(4H)-one chemical structure, C12H11NO3, CAS 57784-65-3
(E)-4-(Ethoxymethylene)-2-phenyloxazol-5(4H)-one
CAS 57784-65-3C12H11NO3
Oxazolone chemical structure, C12H11NO3, CAS 15646-46-5
Oxazolone
CAS 15646-46-5C12H11NO3
(4Z)-2-(4-tert-Butylphenyl)-4-(dimethylaminomethylidene)-1,3-oxazol-5-one chemical structure, C16H20N2O2, CAS 353507-10-5
(4Z)-2-(4-tert-Butylphenyl)-4-(dimethylaminomethylidene)-1,3-oxazol-5-one
CAS 353507-10-5C16H20N2O2
(4E)-4-(Dimethylaminomethylidene)-2-(4-methylphenyl)-1,3-oxazol-5-one chemical structure, C13H14N2O2, CAS 154821-60-0
(4E)-4-(Dimethylaminomethylidene)-2-(4-methylphenyl)-1,3-oxazol-5-one
CAS 154821-60-0C13H14N2O2
(4Z)-4-(Dimethylaminomethylidene)-2-(4-methylphenyl)-1,3-oxazol-5-one chemical structure, C13H14N2O2
(4Z)-4-(Dimethylaminomethylidene)-2-(4-methylphenyl)-1,3-oxazol-5-one
C13H14N2O2