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Murcko scaffold

Ring system with 3 rings and 18 atoms

34 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
34
With full pages
3
Scaffold SMILES

c1ccc(N2CCN(C3CCNCC3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCN(C3CCNCC3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

4-(4-(4-(Aminoiminomethyl)phenyl)-1-piperazinyl)-1-piperidineacetic acid hydrochloride chemical structure, C18H28ClN5O2, CAS 201304-22-5
4-(4-(4-(Aminoiminomethyl)phenyl)-1-piperazinyl)-1-piperidineacetic acid hydrochloride
CAS 201304-22-5C18H28ClN5O2
GR 144053 chemical structure, C18H27N5O2, CAS 150040-22-5
GR 144053
CAS 150040-22-5C18H27N5O2
1-(2-Methoxyphenyl)-4-(1-propan-2-ylpiperidin-4-yl)piperazine chemical structure, C19H31N3O, CAS 432013-45-1
1-(2-Methoxyphenyl)-4-(1-propan-2-ylpiperidin-4-yl)piperazine
CAS 432013-45-1C19H31N3O
1-(2-Methoxyphenyl)-4-(1-propylpiperidin-4-yl)piperazine chemical structure, C19H31N3O, CAS 416864-63-6
1-(2-Methoxyphenyl)-4-(1-propylpiperidin-4-yl)piperazine
CAS 416864-63-6C19H31N3O
1-[4-[4-(2-Fluorophenyl)piperazin-1-yl]piperidin-1-yl]-3-methylbutan-1-one chemical structure, C20H30FN3O, CAS 792927-94-7
1-[4-[4-(2-Fluorophenyl)piperazin-1-yl]piperidin-1-yl]-3-methylbutan-1-one
CAS 792927-94-7C20H30FN3O
1-(1-Ethylsulfonylpiperidin-4-yl)-4-(2-fluorophenyl)piperazine chemical structure, C17H26FN3O2S, CAS 792927-85-6
1-(1-Ethylsulfonylpiperidin-4-yl)-4-(2-fluorophenyl)piperazine
CAS 792927-85-6C17H26FN3O2S
1-[1-(Ethylsulfonyl)-4-piperidinyl]-4-phenylpiperazine chemical structure, C17H27N3O2S, CAS 792927-86-7
1-[1-(Ethylsulfonyl)-4-piperidinyl]-4-phenylpiperazine
CAS 792927-86-7C17H27N3O2S
1-(1-Methylpiperidin-4-yl)-4-(4-nitrophenyl)piperazine chemical structure, C16H24N4O2, CAS 416867-97-5
1-(1-Methylpiperidin-4-yl)-4-(4-nitrophenyl)piperazine
CAS 416867-97-5C16H24N4O2
1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]-3-methylbutan-1-one chemical structure, C21H33N3O2, CAS 792927-95-8
1-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]-3-methylbutan-1-one
CAS 792927-95-8C21H33N3O2
tert-Butyl (4-{4-[4-(N-hydroxycarbamimidoyl)phenyl]piperazin-1-yl}piperidin-1-yl)acetate chemical structure, C22H35N5O3, CAS 149554-31-4
tert-Butyl (4-{4-[4-(N-hydroxycarbamimidoyl)phenyl]piperazin-1-yl}piperidin-1-yl)acetate
CAS 149554-31-4C22H35N5O3
1,1-Dimethylethyl 4-[4-(4-cyanophenyl)-1-piperazinyl]-1-piperidineacetate chemical structure, C22H32N4O2, CAS 149554-04-1
1,1-Dimethylethyl 4-[4-(4-cyanophenyl)-1-piperazinyl]-1-piperidineacetate
CAS 149554-04-1C22H32N4O2
GR 144053 trihydrochloride chemical structure, C18H30Cl3N5O2, CAS 1215333-48-4
GR 144053 trihydrochloride
CAS 1215333-48-4C18H30Cl3N5O2
1-(3-Chlorophenyl)-4-(piperidin-4-yl)piperazine chemical structure, C15H22ClN3, CAS 1082942-54-8
1-(3-Chlorophenyl)-4-(piperidin-4-yl)piperazine
CAS 1082942-54-8C15H22ClN3
1-(2-Fluorophenyl)-4-(piperidin-4-yl)piperazine chemical structure, C15H22FN3, CAS 1082818-37-8
1-(2-Fluorophenyl)-4-(piperidin-4-yl)piperazine
CAS 1082818-37-8C15H22FN3
1-[4-[4-(3-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]ethanone chemical structure, C18H27N3O2, CAS 864415-37-2
1-[4-[4-(3-Methoxyphenyl)piperazin-1-yl]piperidin-1-yl]ethanone
CAS 864415-37-2C18H27N3O2
tert-Butyl 4-(4-(4-aminophenyl)piperazin-1-yl)piperidine-1-carboxylate chemical structure, C20H32N4O2, CAS 223536-01-4
tert-Butyl 4-(4-(4-aminophenyl)piperazin-1-yl)piperidine-1-carboxylate
CAS 223536-01-4C20H32N4O2
4-[4-(1-Boc-4-piperidyl)-1-piperazinyl]benzoic Acid chemical structure, C21H31N3O4, CAS 223535-87-3
4-[4-(1-Boc-4-piperidyl)-1-piperazinyl]benzoic Acid
CAS 223535-87-3C21H31N3O4
2-Methoxy-4-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)aniline chemical structure, C17H28N4O, CAS 877676-39-6
2-Methoxy-4-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)aniline
CAS 877676-39-6C17H28N4O
1-(4-Chlorophenyl)-4-(piperidin-4-yl)piperazine chemical structure, C15H22ClN3, CAS 1284283-28-8
1-(4-Chlorophenyl)-4-(piperidin-4-yl)piperazine
CAS 1284283-28-8C15H22ClN3
1-(2-Chlorophenyl)-4-(piperidin-4-yl)piperazine chemical structure, C15H22ClN3, CAS 1282987-55-6
1-(2-Chlorophenyl)-4-(piperidin-4-yl)piperazine
CAS 1282987-55-6C15H22ClN3
4-[4-(1-Methylpiperidin-4-yl)piperazin-1-yl]aniline chemical structure, C16H26N4, CAS 955087-41-9
4-[4-(1-Methylpiperidin-4-yl)piperazin-1-yl]aniline
CAS 955087-41-9C16H26N4
3-Methyl-4-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]benzenamine chemical structure, C17H28N4, CAS 1254059-73-8
3-Methyl-4-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]benzenamine
CAS 1254059-73-8C17H28N4
1-(3-Methoxy-4-nitrophenyl)-4-(1-methylpiperidin-4-yl)piperazine chemical structure, C17H26N4O3, CAS 1259274-15-1
1-(3-Methoxy-4-nitrophenyl)-4-(1-methylpiperidin-4-yl)piperazine
CAS 1259274-15-1C17H26N4O3
1-(2-Methyl-4-nitrophenyl)-4-(1-methylpiperidin-4-yl)piperazine chemical structure, C17H26N4O2, CAS 1254059-72-7
1-(2-Methyl-4-nitrophenyl)-4-(1-methylpiperidin-4-yl)piperazine
CAS 1254059-72-7C17H26N4O2