Murcko scaffold
Ring system with 2 rings and 15 atoms
38 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 15
- Chemicals
- 38
- With full pages
- 7
Scaffold SMILES
O=C(Nc1ccccc1)Nc1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 38 of 38 chemicals
![2-[[Anilino(oxo)methyl]amino]-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C14H15N3O2S, CAS 433315-76-5](/s/MWIROVVCDJHCQY-UHFFFAOYSA-N.svg)
2-[[Anilino(oxo)methyl]amino]-4,5-dimethyl-3-thiophenecarboxamide
CAS 433315-76-5C14H15N3O2S
![2-[(4-Chlorophenyl)carbamoylamino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C14H14ClN3O2S, CAS 433327-37-8](/s/RAVOBQYXESYQKH-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)carbamoylamino]-4,5-dimethylthiophene-3-carboxamide
CAS 433327-37-8C14H14ClN3O2S
![Methyl 2-[(3-chlorophenyl)carbamoylamino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C15H15ClN2O3S, CAS 540789-59-1](/s/SQGYGJYLBBNULC-UHFFFAOYSA-N.svg)
Methyl 2-[(3-chlorophenyl)carbamoylamino]-4,5-dimethylthiophene-3-carboxylate
CAS 540789-59-1C15H15ClN2O3S
![Ethyl 5-[(4-chlorophenyl)carbamoylamino]-3-methylthiophene-2-carboxylate chemical structure, C15H15ClN2O3S, CAS 380181-08-8](/s/RGUGPYBGFLDYNY-UHFFFAOYSA-N.svg)
Ethyl 5-[(4-chlorophenyl)carbamoylamino]-3-methylthiophene-2-carboxylate
CAS 380181-08-8C15H15ClN2O3S
![2-[(3-Chlorophenyl)carbamoylamino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H16ClN3O2S, CAS 541529-91-3](/s/YNXJYJIQCHRZHD-UHFFFAOYSA-N.svg)
2-[(3-Chlorophenyl)carbamoylamino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 541529-91-3C15H16ClN3O2S
![2-[(4-Chlorophenyl)carbamoylamino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H16ClN3O2S, CAS 424803-20-3](/s/JNKODYOULANAOV-UHFFFAOYSA-N.svg)
2-[(4-Chlorophenyl)carbamoylamino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 424803-20-3C15H16ClN3O2S
![Methyl 2-[(3-chlorophenyl)carbamoylamino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C19H22ClN3O4S, CAS 544657-26-3](/s/COTXTWPFPGZLFZ-UHFFFAOYSA-N.svg)
Methyl 2-[(3-chlorophenyl)carbamoylamino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 544657-26-3C19H22ClN3O4S
![2-[(3,4-Dichlorophenyl)carbamoylamino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H15Cl2N3O2S, CAS 544667-33-6](/s/JLGQDRCQLNGNLH-UHFFFAOYSA-N.svg)
2-[(3,4-Dichlorophenyl)carbamoylamino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 544667-33-6C15H15Cl2N3O2S
Methyl 5-(diethylcarbamoyl)-4-methyl-2-(phenylcarbamoylamino)thiophene-3-carboxylate
CAS 544435-19-0C19H23N3O4S
![4-O-Ethyl 2-O-methyl 3-methyl-5-[(4-methylphenyl)carbamoylamino]thiophene-2,4-dicarboxylate chemical structure, C18H20N2O5S, CAS 445005-25-4](/s/IAOWOVSWIIWRID-UHFFFAOYSA-N.svg)
4-O-Ethyl 2-O-methyl 3-methyl-5-[(4-methylphenyl)carbamoylamino]thiophene-2,4-dicarboxylate
CAS 445005-25-4C18H20N2O5S
![Propan-2-yl 2-[(3-chlorophenyl)carbamoylamino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C21H26ClN3O4S, CAS 550353-77-0](/s/CNDAZIRAKWQVCM-UHFFFAOYSA-N.svg)
Propan-2-yl 2-[(3-chlorophenyl)carbamoylamino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 550353-77-0C21H26ClN3O4S
![2-[(3,4-Dichlorophenyl)carbamoylamino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C14H13Cl2N3O2S, CAS 420091-50-5](/s/AYWDNZZTNSGLLB-UHFFFAOYSA-N.svg)
2-[(3,4-Dichlorophenyl)carbamoylamino]-4,5-dimethylthiophene-3-carboxamide
CAS 420091-50-5C14H13Cl2N3O2S
Ethyl 2-(3-(4-chlorophenyl)ureido)-4,5-dimethylthiophene-3-carboxylate
CAS 379727-14-7C16H17ClN2O3S
![4-Ethyl-5-methyl-2-[(4-toluidinocarbonyl)amino]thiophene-3-carboxamide chemical structure, C16H19N3O2S, CAS 514857-10-4](/s/TUZPFCVDQXGLPP-UHFFFAOYSA-N.svg)
4-Ethyl-5-methyl-2-[(4-toluidinocarbonyl)amino]thiophene-3-carboxamide
CAS 514857-10-4C16H19N3O2S
Ethyl 5-(diethylcarbamoyl)-4-methyl-2-(phenylcarbamoylamino)thiophene-3-carboxylate
CAS 362680-23-7C20H25N3O4S
![5-[(3,4-Dichlorophenyl)carbamoylamino]-2-N,2-N-diethyl-3-methylthiophene-2,4-dicarboxamide chemical structure, C18H20Cl2N4O3S, CAS 727656-20-4](/s/GRRXVHXJZJVDHF-UHFFFAOYSA-N.svg)
5-[(3,4-Dichlorophenyl)carbamoylamino]-2-N,2-N-diethyl-3-methylthiophene-2,4-dicarboxamide
CAS 727656-20-4C18H20Cl2N4O3S
![Ethyl 4-carbamoyl-5-[(3-chlorophenyl)carbamoylamino]-3-methylthiophene-2-carboxylate chemical structure, C16H16ClN3O4S, CAS 355384-13-3](/s/YVXOCRJJJOIRRE-UHFFFAOYSA-N.svg)
Ethyl 4-carbamoyl-5-[(3-chlorophenyl)carbamoylamino]-3-methylthiophene-2-carboxylate
CAS 355384-13-3C16H16ClN3O4S
Propan-2-yl 5-(diethylcarbamoyl)-4-methyl-2-(phenylcarbamoylamino)thiophene-3-carboxylate
CAS 424800-90-8C21H27N3O4S
![Ethyl 5-[(3,4-dichlorophenyl)carbamoylamino]-3-methylthiophene-2-carboxylate chemical structure, C15H14Cl2N2O3S, CAS 380180-79-0](/s/HOYLKKPHWMLTSI-UHFFFAOYSA-N.svg)
Ethyl 5-[(3,4-dichlorophenyl)carbamoylamino]-3-methylthiophene-2-carboxylate
CAS 380180-79-0C15H14Cl2N2O3S
![Ethyl 3-methyl-5-[(phenylcarbamoyl)amino]thiophene-2-carboxylate chemical structure, C15H16N2O3S, CAS 380181-03-3](/s/LIOCFOVPVPJWBE-UHFFFAOYSA-N.svg)
Ethyl 3-methyl-5-[(phenylcarbamoyl)amino]thiophene-2-carboxylate
CAS 380181-03-3C15H16N2O3S
![Ethyl 2-[(anilinocarbonyl)amino]-4,5-dimethyl-3-thiophenecarboxylate chemical structure, C16H18N2O3S, CAS 106666-26-6](/s/AVLLTWMRMQIJAO-UHFFFAOYSA-N.svg)
Ethyl 2-[(anilinocarbonyl)amino]-4,5-dimethyl-3-thiophenecarboxylate
CAS 106666-26-6C16H18N2O3S
![1-(3-Chloro-4-propan-2-ylsulfonylthiophen-2-yl)-3-[3-(trifluoromethyl)phenyl]urea chemical structure, C15H14ClF3N2O3S2, CAS 4761-87-9](/s/DKSIETXDLFBFRK-UHFFFAOYSA-N.svg)
1-(3-Chloro-4-propan-2-ylsulfonylthiophen-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
CAS 4761-87-9C15H14ClF3N2O3S2
1-(4-Chlorophenyl)-3-(3-cyano-4-ethyl-5-methylthiophen-2-yl)urea
CAS 303136-73-4C15H14ClN3OS
1-(3,4-Dimethoxyphenyl)-3-(thiophen-2-yl)urea
CAS 902936-86-1C13H14N2O3S
- Methyl 2-[(3-chlorophenyl)carbamoylamino]thiophene-3-carboxylate338777-31-4C13H11ClN2O3S
- Ethyl 3-methyl-5-[(4-nitrophenyl)carbamoylamino]thiophene-2-carboxylate380180-68-7C15H15N3O5S
- 1-(4-Chlorophenyl)-3-(3-cyanothiophen-2-yl)urea338777-41-6C12H8ClN3OS
- Ethyl 2-(3-(4-methoxyphenyl)ureido)-4,5-dimethylthiophene-3-carboxylate391867-12-2C17H20N2O4S
- Ethyl 3-methyl-5-[(4-nitrophenyl)carbamoylamino]-4-thiocyanatothiophene-2-carboxylate681165-94-6C16H14N4O5S2
- 2-{[(3-Chlorophenyl)carbamoyl]amino}-4,5-dimethylthiophene-3-carboxamide6386-45-4C14H14ClN3O2S
- Ethyl 4-(aminocarbonyl)-3-methyl-5-[[(phenylamino)carbonyl]amino]-2-thiophenecarboxylate419559-80-1C16H17N3O4S
- 2-[3-(Thiophen-2-yl)-ureido]-benzoic acid674301-51-0C12H10N2O3S
- 2-[(Phenylcarbamoyl)amino]thiophene-3-carboxylic acid213390-64-8C12H10N2O3S
- 5-[(Anilinocarbonyl)amino]thiophene-2-carboxylic acid924862-06-6C12H10N2O3S
- 4,5-Dimethyl-2-[[[(3-methylphenyl)amino]carbonyl]amino]-3-thiophenecarboxylic acid926241-25-0C15H16N2O3S
- N-Methyl-2-(4-(3-(thiophen-2-yl)ureido)phenyl)acetamide1209872-02-5C14H15N3O2S
- 1-(2,3-Difluorophenyl)-3-(thiophen-2-yl)urea2330108-90-0C11H8F2N2OS
- 1-(4-Fluoro-3-methoxyphenyl)-3-(thiophen-2-yl)urea2325284-96-4C12H11FN2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(OCc1ccccc1)N1CCCC161 chemicals
O=C(NCc1ccco1)c1ccccc158 chemicals
O=C(Cc1cccs1)Nc1ccccc141 chemicals
O=C(NCC1CCCO1)c1ccccc138 chemicals
O=C(NCC1CCCN1)c1ccccc138 chemicals
O=C(Cc1ccccc1)Nc1nccs137 chemicals
O=S(=O)(NCc1ccco1)c1ccccc136 chemicals
O=S(=O)(NCC1CCCO1)c1ccccc134 chemicals
O=C(NCc1ccccc1)c1ccco130 chemicals
O=C(NCc1ccccc1)c1cccs128 chemicals
c1ccc(CNCc2ccco2)cc128 chemicals![Scaffold O=C(NCc1ccccc1)c1ccc[nH]1](/scaffold/PSYQATYJXPGBDC-UHFFFAOYSA-N/structure.svg)
O=C(NCc1ccccc1)c1ccc[nH]125 chemicals