Murcko scaffold
2-Hydroxy-5-phenylpyridine scaffold
776 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 776
- With full pages
- 32
Scaffold SMILES
O=c1ccc(-c2ccccc2)c[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccc(-c2ccccc2)c[nH]1](/scaffold/RWFAQYWIBBVEBY-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 289 to 336 of 776 chemicals
5-(3,4-Difluorophenyl)-2-hydroxynicotinic acid
CAS 1261990-73-1C12H7F2NO3
5-(3,4-Difluorophenyl)-2-hydroxyisonicotinic acid
CAS 1261920-45-9C12H7F2NO3
5-(3,5-Difluorophenyl)-2-hydroxynicotinic acid
CAS 1261954-49-7C12H7F2NO3
5-(3,5-Difluorophenyl)-2-hydroxyisonicotinic acid
CAS 1261968-45-9C12H7F2NO3
5-(2,3-Difluorophenyl)-2-hydroxynicotinic acid
CAS 1261765-34-7C12H7F2NO3
5-(2,3-Difluorophenyl)-2-hydroxyisonicotinic acid
CAS 1261618-63-6C12H7F2NO3
5-(2,6-Difluorophenyl)-2-hydroxynicotinic acid
CAS 1261912-45-1C12H7F2NO3
5-(2,6-Difluorophenyl)-2-hydroxyisonicotinic acid
CAS 1261912-54-2C12H7F2NO3
5-(2,5-Difluorophenyl)-2-hydroxynicotinic acid
CAS 1261999-26-1C12H7F2NO3
5-(2,5-Difluorophenyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid
CAS 1262005-21-9C12H7F2NO3
5-(3-Acetylphenyl)-2-hydroxynicotinic acid
CAS 1261976-47-9C14H11NO4
5-(3-Acetylphenyl)-2-hydroxyisonicotinic acid
CAS 1261920-77-7C14H11NO4
5-(4-Acetylphenyl)-2-hydroxynicotinic acid
CAS 1261930-42-0C14H11NO4
5-(4-Acetylphenyl)-2-hydroxyisonicotinic acid
CAS 1261921-02-1C14H11NO4
5-(5-Cyano-2-fluorophenyl)-2-hydroxynicotinic acid
CAS 1261998-41-7C13H7FN2O3
5-(5-Cyano-2-fluorophenyl)-2-hydroxyisonicotinic acid
CAS 1261963-42-1C13H7FN2O3
5-(3-Cyano-2-fluorophenyl)-2-hydroxynicotinic acid
CAS 1261976-67-3C13H7FN2O3
5-(3-Cyano-2-fluorophenyl)-2-hydroxyisonicotinic acid
CAS 1261948-63-3C13H7FN2O3
5-(3-Aminocarbonylphenyl)-2-hydroxynicotinic acid
CAS 1261998-57-5C13H10N2O4
5-(3-Aminocarbonylphenyl)-2-hydroxyisonicotinic acid
CAS 1261905-44-5C13H10N2O4
5-(3-Carboxyphenyl)-2-hydroxynicotinic acid
CAS 1261998-67-7C13H9NO5
5-(3-Carboxyphenyl)-2-hydroxyisonicotinic acid
CAS 1261931-87-6C13H9NO5
5-(4-Carboxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
CAS 1261930-51-1C13H9NO5
5-(4-Carboxyphenyl)-2-hydroxyisonicotinic acid
CAS 1261998-76-8C13H9NO5
- 2-Hydroxy-5-(2-methoxy-5-methylphenyl)nicotinic acid1261921-55-4C14H13NO4
- 2-Hydroxy-5-(2-methoxy-5-methylphenyl)isonicotinic acid1261948-95-1C14H13NO4
- 2-Hydroxy-5-(4-methoxy-2-methylphenyl)nicotinic acid1261977-43-8C14H13NO4
- 2-Hydroxy-5-(4-methoxy-2-methylphenyl)isonicotinic acid1261921-77-0C14H13NO4
- 2-Hydroxy-5-(4-methoxy-3-methylphenyl)nicotinic acid1261905-81-0C14H13NO4
- 2-Hydroxy-5-(4-methoxy-3-methylphenyl)isonicotinic acid1261930-66-8C14H13NO4
- 5-(3-Ethoxyphenyl)-2-hydroxynicotinic acid1261922-07-9C14H13NO4
- 5-(3-Ethoxyphenyl)-2-hydroxyisonicotinic acid1261906-02-8C14H13NO4
- 2-Hydroxy-5-(3-nitrophenyl)isonicotinic acid1261890-32-7C12H8N2O5
- 2-Hydroxy-5-(2-methylthiophenyl)nicotinic acid1261922-10-4C13H11NO3S
- 2-Hydroxy-5-(2-methylthiophenyl)isonicotinic acid1261922-11-5C13H11NO3S
- 2-Hydroxy-5-(3-methylthiophenyl)nicotinic acid1262005-52-6C13H11NO3S
- 2-Hydroxy-5-(3-methylthiophenyl)isonicotinic acid1261931-38-7C13H11NO3S
- 2-Hydroxy-5-(4-methylthiophenyl)isonicotinic acid1261898-83-2C13H11NO3S
- 5-(2-Fluoro-3-methoxyphenyl)-2-hydroxynicotinic acid1261913-37-4C13H10FNO4
- 5-(2-Fluoro-3-methoxyphenyl)-2-hydroxyisonicotinic acid1261896-98-3C13H10FNO4
- 5-(2-Fluoro-4-methoxyphenyl)-2-hydroxynicotinic acid1261898-96-7C13H10FNO4
- 5-(2-Fluoro-4-methoxyphenyl)-2-hydroxyisonicotinic acid1261961-45-8C13H10FNO4
- 5-(2-Fluoro-5-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid1261993-39-8C13H10FNO4
- 5-(2-Fluoro-5-methoxyphenyl)-2-hydroxyisonicotinic acid1261932-46-0C13H10FNO4
- 5-(3-Fluoro-4-methoxyphenyl)-2-hydroxynicotinic acid1261890-54-3C13H10FNO4
- 5-(3-Fluoro-4-methoxyphenyl)-2-hydroxyisonicotinic acid1261909-23-2C13H10FNO4
- 5-(4-Fluoro-3-methoxyphenyl)-2-hydroxynicotinic acid1261982-64-2C13H10FNO4
- 5-(4-Fluoro-3-methoxyphenyl)-2-hydroxyisonicotinic acid1261959-95-8C13H10FNO4
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(-c2ccccc2)cc11,627 chemicals
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c1ccc(C2CCNCC2)cc1277 chemicals
c1ccc(C2CCCCC2)cc1274 chemicals
c1ccc(N2CCCCC2)cc1235 chemicals
c1ccc(-c2ccccn2)cc1219 chemicals
c1ccc(N2CCOCC2)cc1202 chemicals
C1=CC(c2ccccc2)C=CN1155 chemicals
c1ccc(-c2ccncc2)cc1124 chemicals
c1ccc(-c2ccccn2)nc1118 chemicals
c1ccc(N2CCNCC2)nc1112 chemicals
c1ccc(-c2ncccn2)cc1107 chemicals