Murcko scaffold
2-Hydroxy-5-phenylpyridine scaffold
776 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 776
- With full pages
- 32
Scaffold SMILES
O=c1ccc(-c2ccccc2)c[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccc(-c2ccccc2)c[nH]1](/scaffold/RWFAQYWIBBVEBY-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 193 to 240 of 776 chemicals
5-(2-Fluoro-4-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1111116-00-7C13H10FNO3
5-(2-Fluoro-5-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1261981-99-0C13H10FNO3
5-(3-Fluoro-4-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1111115-88-8C13H10FNO3
5-(3-Fluoro-5-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1261889-20-6C13H10FNO3
5-(4-Fluoro-3-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1111102-85-2C13H10FNO3
5-(3-Carbamoyl-4-chlorophenyl)-2-hydroxypyridine
CAS 1261958-32-0C12H9ClN2O2
2-Hydroxy-5-(3-methylsulfonylphenyl)pyridine
CAS 1198416-58-8C12H11NO3S
2-Hydroxy-5-(4-methylsulfonylphenyl)pyridine
CAS 1198416-59-9C12H11NO3S
5-(2-Chloro-4-ethoxyphenyl)-2-hydroxypyridine
CAS 1111115-36-6C13H12ClNO2
2-Chloro-5-(6-oxo-1,6-dihydropyridin-3-yl)benzoic acid
CAS 1261982-17-5C12H8ClNO3
5-(3-(Trifluoromethoxy)phenyl)pyridin-2(1H)-one
CAS 1111109-82-0C12H8F3NO2
2-Hydroxy-5-(4-trifluoromethoxyphenyl)pyridine
CAS 1111109-18-2C12H8F3NO2
5-(2-Fluoro-3-trifluoromethylphenyl)-2-hydroxypyridine
CAS 1261896-25-6C12H7F4NO
5-(4-Fluoro-3-trifluoromethylphenyl)-2-hydroxypyridine
CAS 1261940-14-0C12H7F4NO
5-(3,5-Dicarboxyphenyl)-2-hydroxypyridine
CAS 1261975-14-7C13H9NO5
![5-[4-(Ethylcarbamoyl)-3-fluorophenyl]-2-hydroxypyridine chemical structure, C14H13FN2O2, CAS 1261893-01-9](/s/LAJKHJXMXRTTND-UHFFFAOYSA-N.svg)
5-[4-(Ethylcarbamoyl)-3-fluorophenyl]-2-hydroxypyridine
CAS 1261893-01-9C14H13FN2O2
![5-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-hydroxypyridine chemical structure, C14H12FNO3, CAS 1111102-88-5](/s/PFVHHQAJFZHTEV-UHFFFAOYSA-N.svg)
5-[4-(Ethoxycarbonyl)-3-fluorophenyl]-2-hydroxypyridine
CAS 1111102-88-5C14H12FNO3
5-(2-Chloro-5-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1261957-18-9C13H10ClNO3
5-(3-Chloro-4-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1261896-00-7C13H10ClNO3
5-(4-Chloro-3-methoxycarbonylphenyl)-2-hydroxypyridine
CAS 1261958-69-3C13H10ClNO3
2-Hydroxy-5-(3-methylsulfonylaminophenyl)pyridine
CAS 1261973-62-9C12H12N2O3S
2-Hydroxy-5-(2-methoxy-5-trifluoromethylphenyl)pyridine
CAS 1261940-39-9C13H10F3NO2
2-Hydroxy-5-(4-methoxy-3-trifluoromethylphenyl)pyridine
CAS 1261940-42-4C13H10F3NO2
N,N-Dimethyl-2-(6-oxo-1H-pyridin-3-yl)benzenesulfonamide
CAS 1261940-46-8C13H14N2O3S
- 5-(3-N,N-Dimethylsulfamoylphenyl)-2-hydroxypyridine1198416-54-4C13H14N2O3S
- 5-(4-N,N-Dimethylsulfamoylphenyl)-2-hydroxypyridine1198416-56-6C13H14N2O3S
- tert-Butyl (3-(6-hydroxypyridin-3-yl)phenyl)carbamate1261974-19-9C16H18N2O3
- 5-(4-Boc-aminophenyl)-2-hydroxypyridine1111115-64-0C16H18N2O3
- 5-(3-T-Butylsulfamoylphenyl)-2-hydroxypyridine1261982-80-2C15H18N2O3S
- 5-(4-T-Butylsulfamoylphenyl)-2-hydroxypyridine1261932-41-5C15H18N2O3S
- 2-Hydroxy-5-(2-methylphenyl)isonicotinic acid1261988-01-5C13H11NO3
- 2-Hydroxy-5-(3-methylphenyl)isonicotinic acid1262004-22-7C13H11NO3
- 2-Hydroxy-5-(4-methylphenyl)isonicotinic acid1261944-54-0C13H11NO3
- 5-(3-Aminophenyl)-2-hydroxynicotinic acid1261896-54-1C12H10N2O3
- 5-(3-Aminophenyl)-2-hydroxyisonicotinic acid1261903-30-3C12H10N2O3
- 5-(2-Hydroxyphenyl)-2-hydroxynicotinic acid1261896-57-4C12H9NO4
- 5-(2-Hydroxyphenyl)-2-hydroxyisonicotinic acid1261944-56-2C12H9NO4
- 5-(3-Hydroxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid1261953-52-9C12H9NO4
- 5-(3-Hydroxyphenyl)-2-hydroxyisonicotinic acid1261955-15-0C12H9NO4
- 5-(4-Hydroxyphenyl)-2-hydroxynicotinic acid1261953-56-3C12H9NO4
- 5-(4-Hydroxyphenyl)-2-hydroxyisonicotinic acid1261988-36-6C12H9NO4
- 5-(3-Cyanophenyl)-2-hydroxynicotinic acid1261967-08-1C13H8N2O3
- 5-(3-Cyanophenyl)-2-hydroxyisonicotinic acid1261903-41-6C13H8N2O3
- 5-(4-Cyanophenyl)-2-hydroxynicotinic acid1261896-67-6C13H8N2O3
- 5-(4-Cyanophenyl)-2-hydroxyisonicotinic acid1261896-69-8C13H8N2O3
- 5-(2-Formylphenyl)-2-hydroxynicotinic acid1261945-37-2C13H9NO4
- 5-(2-Formylphenyl)-2-hydroxyisonicotinic acid1261925-73-8C13H9NO4
- 5-(3-Formylphenyl)-2-hydroxynicotinic acid1261925-84-1C13H9NO4
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(-c2ccccc2)cc11,627 chemicals
c1ccc(N2CCNCC2)cc1595 chemicals
c1ccc(C2CCNCC2)cc1277 chemicals
c1ccc(C2CCCCC2)cc1274 chemicals
c1ccc(N2CCCCC2)cc1235 chemicals
c1ccc(-c2ccccn2)cc1219 chemicals
c1ccc(N2CCOCC2)cc1202 chemicals
C1=CC(c2ccccc2)C=CN1155 chemicals
c1ccc(-c2ccncc2)cc1124 chemicals
c1ccc(-c2ccccn2)nc1118 chemicals
c1ccc(N2CCNCC2)nc1112 chemicals
c1ccc(-c2ncccn2)cc1107 chemicals