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Murcko scaffold

Ring system with 3 rings and 19 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
42
With full pages
3
Scaffold SMILES

c1ccc(Nc2cc(-c3ccccc3)ncn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2cc(-c3ccccc3)ncn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

4-[(6-Phenylpyrimidin-4-yl)amino]benzoic acid chemical structure, C17H13N3O2, CAS 927983-37-7
4-[(6-Phenylpyrimidin-4-yl)amino]benzoic acid
CAS 927983-37-7C17H13N3O2
N-(3-Chloro-4-methoxyphenyl)-6-phenylpyrimidin-4-amine chemical structure, C17H14ClN3O, CAS 1049263-00-4
N-(3-Chloro-4-methoxyphenyl)-6-phenylpyrimidin-4-amine
CAS 1049263-00-4C17H14ClN3O
4-[(6-Phenylpyrimidin-4-yl)amino]phenol chemical structure, C16H13N3O, CAS 927970-58-9
4-[(6-Phenylpyrimidin-4-yl)amino]phenol
CAS 927970-58-9C16H13N3O
N-(2,4-Dimethoxyphenyl)-6-phenylpyrimidin-4-amine chemical structure, C18H17N3O2, CAS 1203284-63-2
N-(2,4-Dimethoxyphenyl)-6-phenylpyrimidin-4-amine
CAS 1203284-63-2C18H17N3O2
N-(4-((6-Phenylpyrimidin-4-yl)amino)phenyl)acetamide chemical structure, C18H16N4O, CAS 914217-70-2
N-(4-((6-Phenylpyrimidin-4-yl)amino)phenyl)acetamide
CAS 914217-70-2C18H16N4O
4-[(6-Phenylpyrimidin-4-yl)amino]benzenesulfonamide chemical structure, C16H14N4O2S, CAS 927970-70-5
4-[(6-Phenylpyrimidin-4-yl)amino]benzenesulfonamide
CAS 927970-70-5C16H14N4O2S
Gnf-2 chemical structure, C18H13F3N4O2, CAS 778270-11-4
Gnf-2
CAS 778270-11-4C18H13F3N4O2
3-[6-(4-Trifluoromethoxy-phenylamino)-pyrimidin-4-yl]-benzoic acid chemical structure, C18H12F3N3O3, CAS 714962-05-7
3-[6-(4-Trifluoromethoxy-phenylamino)-pyrimidin-4-yl]-benzoic acid
CAS 714962-05-7C18H12F3N3O3
2,4-Pyrimidinediamine, 6-(5-chloro-2-methylphenyl)-N4-(4-(trifluoromethyl)phenyl)- chemical structure, C18H14ClF3N4, CAS 710334-99-9
2,4-Pyrimidinediamine, 6-(5-chloro-2-methylphenyl)-N4-(4-(trifluoromethyl)phenyl)-
CAS 710334-99-9C18H14ClF3N4
Benzenemethanol, 4-((2-amino-6-(5-chloro-2-ethoxyphenyl)-4-pyrimidinyl)amino)- chemical structure, C19H19ClN4O2, CAS 710335-06-1
Benzenemethanol, 4-((2-amino-6-(5-chloro-2-ethoxyphenyl)-4-pyrimidinyl)amino)-
CAS 710335-06-1C19H19ClN4O2
4-[2-Amino-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid methyl ester chemical structure, C19H17ClN4O3, CAS 774606-14-3
4-[2-Amino-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-4-ylamino]-benzoic acid methyl ester
CAS 774606-14-3C19H17ClN4O3
4-Anilino-2-(methylthio)-6-phenylpyrimidine-5-carbonitrile chemical structure, C18H14N4S, CAS 68473-05-2
4-Anilino-2-(methylthio)-6-phenylpyrimidine-5-carbonitrile
CAS 68473-05-2C18H14N4S
N4,6-Diphenylpyrimidine-2,4-diamine chemical structure, C16H14N4, CAS 76369-29-4
N4,6-Diphenylpyrimidine-2,4-diamine
CAS 76369-29-4C16H14N4
4-Anilino-6-phenylpyrimidine-5-carbonitrile chemical structure, C17H12N4, CAS 76990-17-5
4-Anilino-6-phenylpyrimidine-5-carbonitrile
CAS 76990-17-5C17H12N4
4-Anilino-6-(4-nitrophenyl)pyrimidine-5-carbonitrile chemical structure, C17H11N5O2, CAS 89549-70-2
4-Anilino-6-(4-nitrophenyl)pyrimidine-5-carbonitrile
CAS 89549-70-2C17H11N5O2
4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile chemical structure, C18H14N4O, CAS 89549-69-9
4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile
CAS 89549-69-9C18H14N4O
4-Methyl-3-[(6-phenylpyrimidin-4-yl)amino]benzoic acid hydrochloride chemical structure, C18H16ClN3O2, CAS 1055196-62-7
4-Methyl-3-[(6-phenylpyrimidin-4-yl)amino]benzoic acid hydrochloride
CAS 1055196-62-7C18H16ClN3O2
N-(2-Methoxy-5-methylphenyl)-2-methyl-6-phenylpyrimidin-4-amine chemical structure, C19H19N3O, CAS 1021281-75-3
N-(2-Methoxy-5-methylphenyl)-2-methyl-6-phenylpyrimidin-4-amine
CAS 1021281-75-3C19H19N3O
4-[(2-Methyl-6-phenylpyrimidin-4-yl)amino]phenol chemical structure, C17H15N3O, CAS 927966-69-6
4-[(2-Methyl-6-phenylpyrimidin-4-yl)amino]phenol
CAS 927966-69-6C17H15N3O
N-(2-Methoxy-5-methylphenyl)-2-methyl-6-(3-methylphenyl)pyrimidin-4-amine chemical structure, C20H21N3O, CAS 1019132-74-1
N-(2-Methoxy-5-methylphenyl)-2-methyl-6-(3-methylphenyl)pyrimidin-4-amine
CAS 1019132-74-1C20H21N3O
(3-{[6-(2-Methoxyphenyl)pyrimidin-4-yl]amino}phenyl)methanesulfonamide chemical structure, C18H18N4O3S, CAS 1073485-20-7
(3-{[6-(2-Methoxyphenyl)pyrimidin-4-yl]amino}phenyl)methanesulfonamide
CAS 1073485-20-7C18H18N4O3S
4-{[6-(4-Fluorophenyl)pyrimidin-4-yl]-amino}benzoic acid chemical structure, C17H12FN3O2, CAS 1119453-11-0
4-{[6-(4-Fluorophenyl)pyrimidin-4-yl]-amino}benzoic acid
CAS 1119453-11-0C17H12FN3O2
3-{[6-(4-Methylphenyl)pyrimidin-4-yl]-amino}benzoic acid chemical structure, C18H15N3O2, CAS 1119450-53-1
3-{[6-(4-Methylphenyl)pyrimidin-4-yl]-amino}benzoic acid
CAS 1119450-53-1C18H15N3O2
N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)-4-pyrimidinyl)benzamide chemical structure, C20H17F3N4O3, CAS 778277-15-9
N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)-4-pyrimidinyl)benzamide
CAS 778277-15-9C20H17F3N4O3