Murcko scaffold
2-Oxa-7-azaspiro(4.4)nonane scaffold
106 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 9
- Chemicals
- 106
- With full pages
- 6
Scaffold SMILES
C1CC2(CCOC2)CN1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 106 chemicals
2-Oxa-7-azaspiro(4.4)nonane
CAS 175-97-3C7H13NO
![6-Methyl-2-oxa-7-azaspiro[4.4]nonane chemical structure, C8H15NO, CAS 1339152-15-6](/s/USKVYYWSOMUZFX-UHFFFAOYSA-N.svg)
6-Methyl-2-oxa-7-azaspiro[4.4]nonane
CAS 1339152-15-6C8H15NO
![2-Oxa-7-azaspiro[4.4]nonane-9-carboxylic acid chemical structure, C8H13NO3, CAS 1341929-36-9](/s/PBHNFNXCFFXFHC-UHFFFAOYSA-N.svg)
2-Oxa-7-azaspiro[4.4]nonane-9-carboxylic acid
CAS 1341929-36-9C8H13NO3
![(5S,8S)-7-[(tert-Butoxy)carbonyl]-2-oxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C13H21NO5, CAS 1469800-94-9](/s/NHISLUNQHGIFLP-TVQRCGJNSA-N.svg)
(5S,8S)-7-[(tert-Butoxy)carbonyl]-2-oxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 1469800-94-9C13H21NO5
![2-Oxa-7-azaspiro[4.4]nonane hydrochloride chemical structure, C7H14ClNO, CAS 1419590-58-1](/s/WUDSMBVEMCDBBA-UHFFFAOYSA-N.svg)
2-Oxa-7-azaspiro[4.4]nonane hydrochloride
CAS 1419590-58-1C7H14ClNO
![7-(tert-Butoxycarbonyl)-2-oxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C13H21NO5, CAS 2383884-24-8](/s/NHISLUNQHGIFLP-UHFFFAOYSA-N.svg)
7-(tert-Butoxycarbonyl)-2-oxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 2383884-24-8C13H21NO5
![1,1,3,3-Tetramethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid chemical structure, C12H21NO3, CAS 1518069-33-4](/s/LUASMSRAVCDCKM-UHFFFAOYSA-N.svg)
1,1,3,3-Tetramethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid
CAS 1518069-33-4C12H21NO3
![3,3-Dimethyl-2-oxa-7-azaspiro[4.4]nonane chemical structure, C9H17NO, CAS 1706435-18-8](/s/VLVLCKNPSNJGDP-UHFFFAOYSA-N.svg)
3,3-Dimethyl-2-oxa-7-azaspiro[4.4]nonane
CAS 1706435-18-8C9H17NO
![1-Methyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid chemical structure, C9H15NO3, CAS 1543560-40-2](/s/STLHTISAYMEEJY-UHFFFAOYSA-N.svg)
1-Methyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid
CAS 1543560-40-2C9H15NO3
![4,4-Difluoro-2-oxa-7-azaspiro[4.4]nonane chemical structure, C7H11F2NO, CAS 1501406-41-2](/s/LMYPHFGUCWNNHL-UHFFFAOYSA-N.svg)
4,4-Difluoro-2-oxa-7-azaspiro[4.4]nonane
CAS 1501406-41-2C7H11F2NO
![(R)-2-Oxa-7-azaspiro[4.4]nonane chemical structure, C7H13NO, CAS 2198170-18-0](/s/UGQAXUDFJWQPHM-SSDOTTSWSA-N.svg)
(R)-2-Oxa-7-azaspiro[4.4]nonane
CAS 2198170-18-0C7H13NO
2-Oxa-7-azaspiro(4.4)nonane-9-carboxylic acid hydrochloride
CAS 1803582-49-1C8H14ClNO3
![Ethyl 1,1,3,3-tetramethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate chemical structure, C14H25NO3, CAS 1715277-20-5](/s/FHMKRPRFUIUEPL-UHFFFAOYSA-N.svg)
Ethyl 1,1,3,3-tetramethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate
CAS 1715277-20-5C14H25NO3
![Methyl 1,1,3,3-tetramethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate chemical structure, C13H23NO3, CAS 1773282-62-4](/s/QYOWGGSUKXXHLF-UHFFFAOYSA-N.svg)
Methyl 1,1,3,3-tetramethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate
CAS 1773282-62-4C13H23NO3
![Methyl 2-oxa-7-azaspiro[4.4]nonane-9-carboxylate chemical structure, C9H15NO3, CAS 1601079-56-4](/s/NGVISGLCSZPRGS-UHFFFAOYSA-N.svg)
Methyl 2-oxa-7-azaspiro[4.4]nonane-9-carboxylate
CAS 1601079-56-4C9H15NO3
![Ethyl 2-oxa-7-azaspiro[4.4]nonane-9-carboxylate chemical structure, C10H17NO3, CAS 1603445-98-2](/s/SVVUUPJOKOXARV-UHFFFAOYSA-N.svg)
Ethyl 2-oxa-7-azaspiro[4.4]nonane-9-carboxylate
CAS 1603445-98-2C10H17NO3
![3-(2-Oxa-7-azaspiro[4.4]nonan-7-yl)propan-1-ol chemical structure, C10H19NO2, CAS 2098068-76-7](/s/GTAFENCPRUHHQR-UHFFFAOYSA-N.svg)
3-(2-Oxa-7-azaspiro[4.4]nonan-7-yl)propan-1-ol
CAS 2098068-76-7C10H19NO2
![tert-Butyl 3-(aminomethyl)-2-oxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C13H24N2O3, CAS 1268520-24-6](/s/SKJDWIYFGRYNMX-UHFFFAOYSA-N.svg)
tert-Butyl 3-(aminomethyl)-2-oxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 1268520-24-6C13H24N2O3
![tert-Butyl 2-oxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C12H21NO3, CAS 1824270-71-4](/s/GMJFWHUEQZMQTK-UHFFFAOYSA-N.svg)
tert-Butyl 2-oxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 1824270-71-4C12H21NO3
![2-(2-Oxa-7-azaspiro[4.4]nonan-7-yl)acetic acid chemical structure, C9H15NO3, CAS 1823248-81-2](/s/OTCSQSOYTZRPLD-UHFFFAOYSA-N.svg)
2-(2-Oxa-7-azaspiro[4.4]nonan-7-yl)acetic acid
CAS 1823248-81-2C9H15NO3
![2-Amino-1-(2-oxa-7-azaspiro[4.4]nonan-7-yl)ethanone chemical structure, C9H16N2O2, CAS 1823251-20-2](/s/XWCGJQBYIRRHBC-UHFFFAOYSA-N.svg)
2-Amino-1-(2-oxa-7-azaspiro[4.4]nonan-7-yl)ethanone
CAS 1823251-20-2C9H16N2O2
![2-Amino-1-(2-oxa-7-azaspiro[4.4]nonan-7-yl)propan-1-one chemical structure, C10H18N2O2, CAS 1822452-29-8](/s/AMYSLFODUSJABQ-UHFFFAOYSA-N.svg)
2-Amino-1-(2-oxa-7-azaspiro[4.4]nonan-7-yl)propan-1-one
CAS 1822452-29-8C10H18N2O2
![Methyl 3,3-dimethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate chemical structure, C11H19NO3, CAS 1935962-72-3](/s/VTBHVXKMFIXJCQ-UHFFFAOYSA-N.svg)
Methyl 3,3-dimethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate
CAS 1935962-72-3C11H19NO3
![Methyl 1,1-dimethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate chemical structure, C11H19NO3, CAS 1876925-69-7](/s/MHJGZDJHYJWOBG-UHFFFAOYSA-N.svg)
Methyl 1,1-dimethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylate
CAS 1876925-69-7C11H19NO3
- 3,3-Dimethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid1936111-16-8C10H17NO3
- tert-Butyl 3-(iodomethyl)-2-oxa-7-azaspiro[4.4]nonane-7-carboxylate2126161-89-3C13H22INO3
- 7-(tert-Butoxycarbonyl)-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid2089651-08-9C13H21NO5
- tert-Butyl 9-(hydroxymethyl)-2-oxa-7-azaspiro[4.4]nonane-7-carboxylate2089648-63-3C13H23NO4
- tert-Butyl 9-formyl-2-oxa-7-azaspiro[4.4]nonane-7-carboxylate2089649-09-0C13H21NO4
- 2-Oxa-7-azaspiro[4.4]nonan-7-amine2156048-48-3C7H14N2O
- 3,3-Dimethyl-2-oxa-7-azaspiro[4.4]nonane hydrochloride2344679-26-9C9H18ClNO
- tert-Butyl (2-oxa-7-azaspiro[4.4]nonan-9-yl)carbamate2411073-23-7C12H22N2O3
- 2-[(3S,5R)-2-Oxa-7-azaspiro[4.4]nonan-3-yl]acetic acid, hydrochloride2550996-60-4C9H16ClNO3
- rac-2-[(3R,5S)-7-[(tert-Butoxy)carbonyl]-2-oxa-7-azaspiro[4.4]nonan-3-yl]aceticacid2490344-50-6C14H23NO5
- Methyl 2-{2-oxa-7-azaspiro[4.4]nonan-3-yl}acetate, trifluoroacetic acid2580248-39-9C12H18F3NO5
- Methyl 2-{2-oxa-7-azaspiro[4.4]nonan-3-yl}acetate2580188-61-8C10H17NO3
- 3-Methyl 2-Oxa-7-azaspiro[4.4]nonane2006189-06-4C8H15NO
- tert-Butyl 9-amino-2-oxa-7-azaspiro[4.4]nonane-7-carboxylate2920404-99-3C12H22N2O3
- 2-Oxa-7-azaspiro[4.4]nonan-4-ol2387596-25-8C7H13NO2
- tert-Butyl (2-oxa-7-azaspiro[4.4]nonan-4-yl)carbamate2385719-76-4C12H22N2O3
- 2-Oxa-7-azaspiro[4.4]nonane-4-carboxylic acid2387596-75-8C8H13NO3
- rac-(3R,5R)-3-Methyl-2-oxa-7-azaspiro[4.4]nonane hydrochloride, cis2613299-58-2C8H16ClNO
- 2-Oxa-7-azaspiro[4.4]nonane hemioxalate2828444-89-7C16H28N2O6
- 7-(tert-Butoxycarbonyl)-2-oxa-7-azaspiro[4.4]nonane-3-carboxylic acid2385392-79-8C13H21NO5
- Methyl({2-oxa-7-azaspiro[4.4]nonan-3-yl}methyl)(propan-2-yl)amine2138173-68-7C12H24N2O
- Methyl({2-oxa-7-azaspiro[4.4]nonan-3-yl}methyl)propylamine2138173-72-3C12H24N2O
- 7-[(tert-Butoxy)carbonyl]-3,3-dimethyl-2-oxa-7-azaspiro[4.4]nonane-9-carboxylic acid2172013-32-8C15H25NO5
- Diethyl({2-oxa-7-azaspiro[4.4]nonan-3-yl}methyl)amine2137751-82-5C12H24N2O
Related scaffolds
Same ring framework with different atoms or bond orders
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C1CCC2(C1)CCCN213 chemicals
C1CCC2(C1)OCCO29 chemicals
C1CCC2(C1)CCCC29 chemicals
C1CC2(CCNC2)CN17 chemicals
C1CC2(CN1)OCCO27 chemicals
C1CCC2(C1)CCCO26 chemicals![Scaffold C1CC[N+]2(C1)CCCC2](/scaffold/NZSICTQUKULOSA-UHFFFAOYSA-N/structure.svg)
C1CC[N+]2(C1)CCCC25 chemicals
C1COC2(C1)CCOC24 chemicals
C1CNC2(C1)CCNC24 chemicals
O=C1NC(=O)C2(CCNC2)N14 chemicals