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Murcko scaffold

1,4-Dioxa-7-azaspiro(4.4)nonane scaffold

51 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
51
With full pages
7
Scaffold SMILES

C1CC2(CN1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dioxa-7-azaspiro(4.4)nonane page
Murcko scaffold C1CC2(CN1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

1,4-Dioxa-7-azaspiro[4.4]nonan-7-ol chemical structure, C6H11NO3, CAS 400820-21-5
1,4-Dioxa-7-azaspiro[4.4]nonan-7-ol
CAS 400820-21-5C6H11NO3
(8S)-1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C7H11NO4, CAS 75776-51-1
(8S)-1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 75776-51-1C7H11NO4
1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-(3-mercapto-2-methyl-1-oxopropyl)-, [S-(R*,R*)]- chemical structure, C11H17NO5S, CAS 75776-53-3
1,4-Dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid, 7-(3-mercapto-2-methyl-1-oxopropyl)-, [S-(R*,R*)]-
CAS 75776-53-3C11H17NO5S
Methyl (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate chemical structure, C8H13NO4, CAS 66682-58-4
Methyl (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate
CAS 66682-58-4C8H13NO4
1,4-Dioxa-7-azaspiro(4.4)nonane chemical structure, C6H11NO2, CAS 176-33-0
1,4-Dioxa-7-azaspiro(4.4)nonane
CAS 176-33-0C6H11NO2
Ethyl (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate chemical structure, C9H15NO4, CAS 182629-54-5
Ethyl (8S)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate
CAS 182629-54-5C9H15NO4
{7-Methyl-1,4-dioxa-7-azaspiro[4.4]nonan-2-yl}methanol chemical structure, C8H15NO3, CAS 2171912-67-5
{7-Methyl-1,4-dioxa-7-azaspiro[4.4]nonan-2-yl}methanol
CAS 2171912-67-5C8H15NO3
1,4-Dioxa-7-azaspiro[4.4]nonane hydrochloride chemical structure, C6H12ClNO2, CAS 2445249-57-8
1,4-Dioxa-7-azaspiro[4.4]nonane hydrochloride
CAS 2445249-57-8C6H12ClNO2
(S)-7-((S)-2-(Methoxycarbonylamino)-3-methylbutanoyl)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C14H22N2O7, CAS 1256390-38-1
(S)-7-((S)-2-(Methoxycarbonylamino)-3-methylbutanoyl)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 1256390-38-1C14H22N2O7
Methyl (S)-7-((methoxycarbonyl)-L-valyl)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate chemical structure, C15H24N2O7, CAS 1272654-95-1
Methyl (S)-7-((methoxycarbonyl)-L-valyl)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate
CAS 1272654-95-1C15H24N2O7
Ethyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C9H15NO4, CAS 14891-11-3
Ethyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 14891-11-3C9H15NO4
(S)-tert-Butyl 8-(aminomethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C12H22N2O4, CAS 1447616-20-7
(S)-tert-Butyl 8-(aminomethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 1447616-20-7C12H22N2O4
(S)-tert-Butyl 8-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C12H21NO5, CAS 1447616-14-9
(S)-tert-Butyl 8-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 1447616-14-9C12H21NO5
9-Ethyl-1,4-dioxa-7-azaspiro(4.4)nonane chemical structure, C8H15NO2, CAS 1421603-46-4
9-Ethyl-1,4-dioxa-7-azaspiro(4.4)nonane
CAS 1421603-46-4C8H15NO2
1,4-Dioxa-7-aza-spiro[4.4]nonane oxalate chemical structure, C8H13NO6, CAS 14891-13-5
1,4-Dioxa-7-aza-spiro[4.4]nonane oxalate
CAS 14891-13-5C8H13NO6
tert-Butyl 8-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C12H21NO5, CAS 1822514-92-0
tert-Butyl 8-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 1822514-92-0C12H21NO5
2-(Chloromethyl)-7-methyl-1,4-dioxa-7-azaspiro[4.4]nonane chemical structure, C8H14ClNO2, CAS 1552575-12-8
2-(Chloromethyl)-7-methyl-1,4-dioxa-7-azaspiro[4.4]nonane
CAS 1552575-12-8C8H14ClNO2
{7-Methyl-1,4-dioxa-7-azaspiro[4.4]nonan-2-yl}methanamine chemical structure, C8H16N2O2, CAS 1552645-64-3
{7-Methyl-1,4-dioxa-7-azaspiro[4.4]nonan-2-yl}methanamine
CAS 1552645-64-3C8H16N2O2
(8S)-7-tert-Butoxycarbonyl-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C12H19NO6, CAS 1446082-13-8
(8S)-7-tert-Butoxycarbonyl-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 1446082-13-8C12H19NO6
1,4-Dioxa-7-azaspiro[4.4]nonane-8-methanol chemical structure, C7H13NO3, CAS 2383606-24-2
1,4-Dioxa-7-azaspiro[4.4]nonane-8-methanol
CAS 2383606-24-2C7H13NO3
Methyl (8R)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate chemical structure, C8H13NO4, CAS 2382620-01-9
Methyl (8R)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylate
CAS 2382620-01-9C8H13NO4
2-{1,4-Dioxa-7-azaspiro[4.4]nonan-7-yl}ethan-1-amine chemical structure, C8H16N2O2, CAS 1862379-72-3
2-{1,4-Dioxa-7-azaspiro[4.4]nonan-7-yl}ethan-1-amine
CAS 1862379-72-3C8H16N2O2
tert-Butyl (8R)-8-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate chemical structure, C12H21NO5, CAS 2580097-78-3
tert-Butyl (8R)-8-(hydroxymethyl)-1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate
CAS 2580097-78-3C12H21NO5
((8R)-1,4-Dioxa-7-azaspiro(4.4)nonan-8-yl)methanol chemical structure, C7H13NO3, CAS 1821519-34-9
((8R)-1,4-Dioxa-7-azaspiro(4.4)nonan-8-yl)methanol
CAS 1821519-34-9C7H13NO3