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Murcko scaffold

RefChem:382286 scaffold

70 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
70
With full pages
18
Scaffold SMILES

O=c1[nH]c(SCc2ccccc2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RefChem:382286 page
Murcko scaffold O=c1[nH]c(SCc2ccccc2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 70 chemicals

4(3H)-Quinazolinone, 2-(((4-methoxyphenyl)methyl)thio)-3-methyl- chemical structure, C17H16N2O2S, CAS 90852-47-4
4(3H)-Quinazolinone, 2-(((4-methoxyphenyl)methyl)thio)-3-methyl-
CAS 90852-47-4C17H16N2O2S
2-[(2-Fluorobenzyl)sulfanyl]-3-methyl-4(3H)-quinazolinone chemical structure, C16H13FN2OS, CAS 90852-30-5
2-[(2-Fluorobenzyl)sulfanyl]-3-methyl-4(3H)-quinazolinone
CAS 90852-30-5C16H13FN2OS
2-Benzylsulfanyl-3-(2-methylprop-2-enyl)quinazolin-4-one chemical structure, C19H18N2OS, CAS 329709-06-0
2-Benzylsulfanyl-3-(2-methylprop-2-enyl)quinazolin-4-one
CAS 329709-06-0C19H18N2OS
3-Allyl-2-(benzylthio)quinazolin-4(3H)-one chemical structure, C18H16N2OS, CAS 90852-38-3
3-Allyl-2-(benzylthio)quinazolin-4(3H)-one
CAS 90852-38-3C18H16N2OS
2-(Benzylsulfanyl)-3-ethyl-4(3H)-quinazolinone chemical structure, C17H16N2OS, CAS 90852-43-0
2-(Benzylsulfanyl)-3-ethyl-4(3H)-quinazolinone
CAS 90852-43-0C17H16N2OS
2-(Benzylsulfanyl)-3-methyl-4(3H)-quinazolinone chemical structure, C16H14N2OS, CAS 90852-28-1
2-(Benzylsulfanyl)-3-methyl-4(3H)-quinazolinone
CAS 90852-28-1C16H14N2OS
3-[(3-Methyl-4-oxoquinazolin-2-yl)sulfanylmethyl]benzonitrile chemical structure, C17H13N3OS, CAS 677302-23-7
3-[(3-Methyl-4-oxoquinazolin-2-yl)sulfanylmethyl]benzonitrile
CAS 677302-23-7C17H13N3OS
2-[(3-Bromophenyl)methylsulfanyl]-3-ethylquinazolin-4-one chemical structure, C17H15BrN2OS, CAS 664993-09-3
2-[(3-Bromophenyl)methylsulfanyl]-3-ethylquinazolin-4-one
CAS 664993-09-3C17H15BrN2OS
Methyl 4-[(4-oxo-3-prop-2-enylquinazolin-2-yl)sulfanylmethyl]benzoate chemical structure, C20H18N2O3S, CAS 315702-31-9
Methyl 4-[(4-oxo-3-prop-2-enylquinazolin-2-yl)sulfanylmethyl]benzoate
CAS 315702-31-9C20H18N2O3S
3-Amino-2-[[3-(trifluoromethyl)phenyl]methylsulfanyl]quinazolin-4-one chemical structure, C16H12F3N3OS, CAS 669703-29-1
3-Amino-2-[[3-(trifluoromethyl)phenyl]methylsulfanyl]quinazolin-4-one
CAS 669703-29-1C16H12F3N3OS
2-[(2-Bromophenyl)methylsulfanyl]-3-methylquinazolin-4-one chemical structure, C16H13BrN2OS, CAS 401827-52-9
2-[(2-Bromophenyl)methylsulfanyl]-3-methylquinazolin-4-one
CAS 401827-52-9C16H13BrN2OS
2-Benzylsulfanyl-6-iodo-3-prop-2-enylquinazolin-4-one chemical structure, C18H15IN2OS, CAS 500274-43-1
2-Benzylsulfanyl-6-iodo-3-prop-2-enylquinazolin-4-one
CAS 500274-43-1C18H15IN2OS
2-Benzylsulfanyl-6-iodo-3-(2-methylprop-2-enyl)quinazolin-4-one chemical structure, C19H17IN2OS, CAS 497941-84-1
2-Benzylsulfanyl-6-iodo-3-(2-methylprop-2-enyl)quinazolin-4-one
CAS 497941-84-1C19H17IN2OS
Methyl 2-(benzylsulfanyl)-3-ethyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate chemical structure, C19H18N2O3S, CAS 517869-33-9
Methyl 2-(benzylsulfanyl)-3-ethyl-4-oxo-3,4-dihydroquinazoline-7-carboxylate
CAS 517869-33-9C19H18N2O3S
4-(((3-Allyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio)methyl)-N-(2-hydroxyethyl)benzamide chemical structure, C21H21N3O3S, CAS 315695-50-2
4-(((3-Allyl-4-oxo-3,4-dihydroquinazolin-2-yl)thio)methyl)-N-(2-hydroxyethyl)benzamide
CAS 315695-50-2C21H21N3O3S
2-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-3-(2-methylpropyl)-3,4-dihydroquinazolin-4-one chemical structure, C19H18Cl2N2OS, CAS 329779-74-0
2-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-3-(2-methylpropyl)-3,4-dihydroquinazolin-4-one
CAS 329779-74-0C19H18Cl2N2OS
3-Methyl-2-((4-methylbenzyl)thio)quinazolin-4(3H)-one chemical structure, C17H16N2OS, CAS 22312-45-4
3-Methyl-2-((4-methylbenzyl)thio)quinazolin-4(3H)-one
CAS 22312-45-4C17H16N2OS
2-(Benzylsulfanyl)-3-ethyl-6,7-dimethoxyquinazolin-4(3H)-one chemical structure, C19H20N2O3S, CAS 517869-43-1
2-(Benzylsulfanyl)-3-ethyl-6,7-dimethoxyquinazolin-4(3H)-one
CAS 517869-43-1C19H20N2O3S
2-[(2-Bromophenyl)methylsulfanyl]-3-ethylquinazolin-4-one chemical structure, C17H15BrN2OS, CAS 876678-60-3
2-[(2-Bromophenyl)methylsulfanyl]-3-ethylquinazolin-4-one
CAS 876678-60-3C17H15BrN2OS
3-Ethyl-2-{[(2,3,4,5,6-pentamethylphenyl)methyl]sulfanyl}-3,4-dihydroquinazolin-4-one chemical structure, C22H26N2OS, CAS 882082-87-3
3-Ethyl-2-{[(2,3,4,5,6-pentamethylphenyl)methyl]sulfanyl}-3,4-dihydroquinazolin-4-one
CAS 882082-87-3C22H26N2OS
Methyl 3-(2-methoxyethyl)-2-[(4-methylphenyl)methylsulfanyl]-4-oxoquinazoline-7-carboxylate chemical structure, C21H22N2O4S, CAS 403728-87-0
Methyl 3-(2-methoxyethyl)-2-[(4-methylphenyl)methylsulfanyl]-4-oxoquinazoline-7-carboxylate
CAS 403728-87-0C21H22N2O4S
Methyl 2-[(2-fluorophenyl)methylsulfanyl]-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate chemical structure, C20H19FN2O4S, CAS 403728-88-1
Methyl 2-[(2-fluorophenyl)methylsulfanyl]-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate
CAS 403728-88-1C20H19FN2O4S
3-Ethyl-2-[(4-fluorobenzyl)sulfanyl]-4(3H)-quinazolinone chemical structure, C17H15FN2OS, CAS 882082-72-6
3-Ethyl-2-[(4-fluorobenzyl)sulfanyl]-4(3H)-quinazolinone
CAS 882082-72-6C17H15FN2OS
Methyl 2-[(3-fluorophenyl)methylsulfanyl]-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate chemical structure, C20H19FN2O4S, CAS 403728-89-2
Methyl 2-[(3-fluorophenyl)methylsulfanyl]-3-(2-methoxyethyl)-4-oxoquinazoline-7-carboxylate
CAS 403728-89-2C20H19FN2O4S