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Murcko scaffold

Ring system with 3 rings and 20 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
16
With full pages
3
Scaffold SMILES

O=c1cc(N2CCNCC2)[nH]c(=O)n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cc(N2CCNCC2)[nH]c(=O)n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-(5-Chloro-2-methylphenyl)-6-(4-ethylpiperazin-1-yl)-1H-pyrimidine-2,4-dione chemical structure, C17H21ClN4O2, CAS 847399-01-3
3-(5-Chloro-2-methylphenyl)-6-(4-ethylpiperazin-1-yl)-1H-pyrimidine-2,4-dione
CAS 847399-01-3C17H21ClN4O2
3-(2-Chlorophenyl)-6-(4-methylpiperazin-1-yl)-1H-pyrimidine-2,4-dione chemical structure, C15H17ClN4O2, CAS 847398-22-5
3-(2-Chlorophenyl)-6-(4-methylpiperazin-1-yl)-1H-pyrimidine-2,4-dione
CAS 847398-22-5C15H17ClN4O2
3-(2-Chlorophenyl)-6-(4-ethylpiperazin-1-yl)-1H-pyrimidine-2,4-dione chemical structure, C16H19ClN4O2, CAS 847398-23-6
3-(2-Chlorophenyl)-6-(4-ethylpiperazin-1-yl)-1H-pyrimidine-2,4-dione
CAS 847398-23-6C16H19ClN4O2
3-(4-Chlorophenyl)-6-(4-ethylpiperazin-1-yl)-1H-pyrimidine-2,4-dione chemical structure, C16H19ClN4O2, CAS 847398-42-9
3-(4-Chlorophenyl)-6-(4-ethylpiperazin-1-yl)-1H-pyrimidine-2,4-dione
CAS 847398-42-9C16H19ClN4O2
6-(4-Ethylpiperazin-1-yl)-3-(4-methoxyphenyl)-1H-pyrimidine-2,4-dione chemical structure, C17H22N4O3, CAS 847398-72-5
6-(4-Ethylpiperazin-1-yl)-3-(4-methoxyphenyl)-1H-pyrimidine-2,4-dione
CAS 847398-72-5C17H22N4O3
Ethyl 4-(1-(3-bromophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C17H19BrN4O4, CAS 847398-97-4
Ethyl 4-(1-(3-bromophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate
CAS 847398-97-4C17H19BrN4O4
Ethyl 4-[1-(4-chlorophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperazine-1-carboxylate chemical structure, C17H19ClN4O4, CAS 847398-44-1
Ethyl 4-[1-(4-chlorophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperazine-1-carboxylate
CAS 847398-44-1C17H19ClN4O4
Ethyl 4-[3-(4-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate chemical structure, C18H22N4O4, CAS 847399-48-8
Ethyl 4-[3-(4-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate
CAS 847399-48-8C18H22N4O4
Ethyl 4-(1-(2-fluorophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C17H19FN4O4, CAS 862828-77-1
Ethyl 4-(1-(2-fluorophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate
CAS 862828-77-1C17H19FN4O4
Ethyl 4-(1-(4-bromophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate chemical structure, C17H19BrN4O4, CAS 847398-84-9
Ethyl 4-(1-(4-bromophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazine-1-carboxylate
CAS 847398-84-9C17H19BrN4O4
Ethyl 4-[3-(2-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate chemical structure, C18H22N4O4, CAS 847399-27-3
Ethyl 4-[3-(2-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate
CAS 847399-27-3C18H22N4O4
3-(3-Bromophenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4(1H,3H)-dione chemical structure, C15H17BrN4O2, CAS 906153-69-3
3-(3-Bromophenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4(1H,3H)-dione
CAS 906153-69-3C15H17BrN4O2
3-(3-Bromophenyl)-6-(4-ethylpiperazin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C16H19BrN4O2, CAS 903319-31-3
3-(3-Bromophenyl)-6-(4-ethylpiperazin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 903319-31-3C16H19BrN4O2
3-(4-Methylphenyl)-6-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C16H20N4O2, CAS 903350-15-2
3-(4-Methylphenyl)-6-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 903350-15-2C16H20N4O2
3-(3-Methylphenyl)-6-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C16H20N4O2, CAS 903286-83-9
3-(3-Methylphenyl)-6-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 903286-83-9C16H20N4O2
6-(4-Ethylpiperazin-1-yl)-3-(3-methylphenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C17H22N4O2, CAS 903350-33-4
6-(4-Ethylpiperazin-1-yl)-3-(3-methylphenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS 903350-33-4C17H22N4O2