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Murcko scaffold

1-(Pyrrolidin-3-yl)piperazine scaffold

75 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
75
With full pages
7
Scaffold SMILES

C1CN(C2CCNC2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Pyrrolidin-3-yl)piperazine page
Murcko scaffold C1CN(C2CCNC2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 75 of 75 chemicals

tert-Butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylate hydrochloride chemical structure, C13H26ClN3O2, CAS 1417361-24-0
tert-Butyl 3-(piperazin-1-yl)pyrrolidine-1-carboxylate hydrochloride
CAS 1417361-24-0C13H26ClN3O2
(3R,4R)-4-(4-Ethylpiperazin-1-yl)pyrrolidin-3-ol chemical structure, C10H21N3O, CAS 1845827-93-1
(3R,4R)-4-(4-Ethylpiperazin-1-yl)pyrrolidin-3-ol
CAS 1845827-93-1C10H21N3O
tert-Butyl (3R,4R)-3-hydroxy-4-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-1-carboxylate chemical structure, C15H29N3O4, CAS 2277362-57-7
tert-Butyl (3R,4R)-3-hydroxy-4-[4-(2-hydroxyethyl)piperazin-1-yl]pyrrolidine-1-carboxylate
CAS 2277362-57-7C15H29N3O4
tert-Butyl (3R,4R)-3-hydroxy-4-(4-methylpiperazin-1-yl)pyrrolidine-1-carboxylate chemical structure, C14H27N3O3, CAS 2277116-76-2
tert-Butyl (3R,4R)-3-hydroxy-4-(4-methylpiperazin-1-yl)pyrrolidine-1-carboxylate
CAS 2277116-76-2C14H27N3O3
tert-Butyl (3R,4R)-3-(4-acetylpiperazin-1-yl)-4-hydroxypyrrolidine-1-carboxylate chemical structure, C15H27N3O4, CAS 2277314-36-8
tert-Butyl (3R,4R)-3-(4-acetylpiperazin-1-yl)-4-hydroxypyrrolidine-1-carboxylate
CAS 2277314-36-8C15H27N3O4
tert-Butyl (3R,4R)-3-hydroxy-4-[4-(propan-2-yl)piperazin-1-yl]pyrrolidine-1-carboxylate chemical structure, C16H31N3O3, CAS 2290813-29-3
tert-Butyl (3R,4R)-3-hydroxy-4-[4-(propan-2-yl)piperazin-1-yl]pyrrolidine-1-carboxylate
CAS 2290813-29-3C16H31N3O3
tert-Butyl (3R,4R)-3-(4-ethylpiperazin-1-yl)-4-hydroxypyrrolidine-1-carboxylate chemical structure, C15H29N3O3, CAS 2290995-80-9
tert-Butyl (3R,4R)-3-(4-ethylpiperazin-1-yl)-4-hydroxypyrrolidine-1-carboxylate
CAS 2290995-80-9C15H29N3O3
tert-Butyl (3R,4R)-3-[4-(2-fluoroethyl)piperazin-1-yl]-4-hydroxypyrrolidine-1-carboxylate chemical structure, C15H28FN3O3, CAS 2290687-91-9
tert-Butyl (3R,4R)-3-[4-(2-fluoroethyl)piperazin-1-yl]-4-hydroxypyrrolidine-1-carboxylate
CAS 2290687-91-9C15H28FN3O3
(3R,4R)-4-(Piperazin-1-yl)pyrrolidin-3-ol chemical structure, C8H17N3O, CAS 1867431-32-0
(3R,4R)-4-(Piperazin-1-yl)pyrrolidin-3-ol
CAS 1867431-32-0C8H17N3O
rac-(3R,4R)-4-[4-(Propan-2-yl)piperazin-1-yl]pyrrolidin-3-ol chemical structure, C11H23N3O, CAS 1867318-87-3
rac-(3R,4R)-4-[4-(Propan-2-yl)piperazin-1-yl]pyrrolidin-3-ol
CAS 1867318-87-3C11H23N3O
rac-(3R,4R)-4-(2-Methylpiperazin-1-yl)pyrrolidin-3-ol chemical structure, C9H19N3O, CAS 1848867-61-7
rac-(3R,4R)-4-(2-Methylpiperazin-1-yl)pyrrolidin-3-ol
CAS 1848867-61-7C9H19N3O
3-(Piperazin-1-yl)pyrrolidine-3-carboxamide chemical structure, C9H18N4O, CAS 1936551-79-9
3-(Piperazin-1-yl)pyrrolidine-3-carboxamide
CAS 1936551-79-9C9H18N4O
1-Boc-4-(3-pyrrolidinyl)piperazine dihydrochloride chemical structure, C13H27Cl2N3O2, CAS 2514936-51-5
1-Boc-4-(3-pyrrolidinyl)piperazine dihydrochloride
CAS 2514936-51-5C13H27Cl2N3O2
4-(4-Methyl-1-piperazinyl)-3-pyrrolidinol dihydrochloride chemical structure, C9H21Cl2N3O, CAS 2206822-94-6
4-(4-Methyl-1-piperazinyl)-3-pyrrolidinol dihydrochloride
CAS 2206822-94-6C9H21Cl2N3O
rac-1-(4-((3R,4R)-4-Hydroxypyrrolidin-3-yl)piperazin-1-yl)ethan-1-one chemical structure, C10H19N3O2, CAS 1841358-43-7
rac-1-(4-((3R,4R)-4-Hydroxypyrrolidin-3-yl)piperazin-1-yl)ethan-1-one
CAS 1841358-43-7C10H19N3O2
tert-Butyl 4-(pyrrolidin-3-yl)piperazine-1-carboxylate hydrochloride chemical structure, C13H26ClN3O2, CAS 2624138-75-4
tert-Butyl 4-(pyrrolidin-3-yl)piperazine-1-carboxylate hydrochloride
CAS 2624138-75-4C13H26ClN3O2
1-(3-Ethylpyrrolidin-3-yl)piperazine chemical structure, C10H21N3, CAS 2137590-96-4
1-(3-Ethylpyrrolidin-3-yl)piperazine
CAS 2137590-96-4C10H21N3
tert-Butyl 3-(2-methylpiperazin-1-yl)pyrrolidine-1-carboxylate chemical structure, C14H27N3O2, CAS 1824006-89-4
tert-Butyl 3-(2-methylpiperazin-1-yl)pyrrolidine-1-carboxylate
CAS 1824006-89-4C14H27N3O2
rac-(3R,4R)-4-[4-(2-Methylpropyl)piperazin-1-yl]pyrrolidin-3-ol chemical structure, C12H25N3O, CAS 1867605-77-3
rac-(3R,4R)-4-[4-(2-Methylpropyl)piperazin-1-yl]pyrrolidin-3-ol
CAS 1867605-77-3C12H25N3O
3-(4-Methylpiperazin-1-yl)pyrrolidine-1-carbonyl chloride chemical structure, C10H18ClN3O, CAS 2172472-19-2
3-(4-Methylpiperazin-1-yl)pyrrolidine-1-carbonyl chloride
CAS 2172472-19-2C10H18ClN3O
3-(4-Methylpiperazin-1-yl)pyrrolidine-1-sulfonyl chloride chemical structure, C9H18ClN3O2S, CAS 2172154-58-2
3-(4-Methylpiperazin-1-yl)pyrrolidine-1-sulfonyl chloride
CAS 2172154-58-2C9H18ClN3O2S
3-(Piperazin-1-yl)pyrrolidine-3-carboxylic acid chemical structure, C9H17N3O2, CAS 2137585-76-1
3-(Piperazin-1-yl)pyrrolidine-3-carboxylic acid
CAS 2137585-76-1C9H17N3O2
tert-Butyl (3S)-3-(piperazin-1-yl)pyrrolidine-1-carboxylate hydrochloride chemical structure, C13H26ClN3O2, CAS 2703748-83-6
tert-Butyl (3S)-3-(piperazin-1-yl)pyrrolidine-1-carboxylate hydrochloride
CAS 2703748-83-6C13H26ClN3O2
tert-Butyl (3R)-3-(piperazin-1-yl)pyrrolidine-1-carboxylate hydrochloride chemical structure, C13H26ClN3O2, CAS 2703749-24-8
tert-Butyl (3R)-3-(piperazin-1-yl)pyrrolidine-1-carboxylate hydrochloride
CAS 2703749-24-8C13H26ClN3O2