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Murcko scaffold

1,4-Dihydro-4-oxo-N-phenyl-3-quinolinecarboxamide scaffold

222 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
222
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)c1c[nH]c2ccccc2c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dihydro-4-oxo-N-phenyl-3-quinolinecarboxamide page
Murcko scaffold O=C(Nc1ccccc1)c1c[nH]c2ccccc2c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 222 chemicals

1,4-Dihydro-N-(2-methylphenyl)-4-oxo-3-quinolinecarboxamide chemical structure, C17H14N2O2, CAS 329691-97-6
1,4-Dihydro-N-(2-methylphenyl)-4-oxo-3-quinolinecarboxamide
CAS 329691-97-6C17H14N2O2
N-(2,4-dimethylphenyl)-1,4-dihydro-4-oxo-3-Quinolinecarboxamide chemical structure, C18H16N2O2, CAS 329691-99-8
N-(2,4-dimethylphenyl)-1,4-dihydro-4-oxo-3-Quinolinecarboxamide
CAS 329691-99-8C18H16N2O2
N-(2,6-Dimethylphenyl)-4-oxo-1H-quinoline-3-carboxamide chemical structure, C18H16N2O2, CAS 329692-01-5
N-(2,6-Dimethylphenyl)-4-oxo-1H-quinoline-3-carboxamide
CAS 329692-01-5C18H16N2O2
N-(2-Ethylphenyl)-4-oxo-1H-quinoline-3-carboxamide chemical structure, C18H16N2O2, CAS 329692-03-7
N-(2-Ethylphenyl)-4-oxo-1H-quinoline-3-carboxamide
CAS 329692-03-7C18H16N2O2
N-(2,6-Dichlorophenyl)-4-oxo-1H-quinoline-3-carboxamide chemical structure, C16H10Cl2N2O2, CAS 329692-05-9
N-(2,6-Dichlorophenyl)-4-oxo-1H-quinoline-3-carboxamide
CAS 329692-05-9C16H10Cl2N2O2
N-(3-Methoxy-4-tert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide chemical structure, C21H22N2O3, CAS 873050-19-2
N-(3-Methoxy-4-tert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide
CAS 873050-19-2C21H22N2O3
4-Hydroxy-N-(4-methoxyphenyl)-3-quinolinecarboxamide chemical structure, C17H14N2O3, CAS 86540-18-3
4-Hydroxy-N-(4-methoxyphenyl)-3-quinolinecarboxamide
CAS 86540-18-3C17H14N2O3
N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide chemical structure, C16H11ClN2O2, CAS 77779-63-6
N-(4-Chlorophenyl)-4-hydroxy-3-quinolinecarboxamide
CAS 77779-63-6C16H11ClN2O2
1,4-Dihydro-N-(2-methoxyphenyl)-4-oxo-3-quinolinecarboxamide chemical structure, C17H14N2O3, CAS 86540-24-1
1,4-Dihydro-N-(2-methoxyphenyl)-4-oxo-3-quinolinecarboxamide
CAS 86540-24-1C17H14N2O3
N-(3,4-Dimethoxyphenyl)-4-hydroxyquinoline-3-carboxamide chemical structure, C18H16N2O4, CAS 86540-25-2
N-(3,4-Dimethoxyphenyl)-4-hydroxyquinoline-3-carboxamide
CAS 86540-25-2C18H16N2O4
4-Hydroxy-N-(3-methoxyphenyl)quinoline-3-carboxamide chemical structure, C17H14N2O3, CAS 86540-27-4
4-Hydroxy-N-(3-methoxyphenyl)quinoline-3-carboxamide
CAS 86540-27-4C17H14N2O3
4-Hydroxy-N-phenyl-8-(trifluoromethyl)quinoline-3-carboxamide chemical structure, C17H11F3N2O2, CAS 114350-68-4
4-Hydroxy-N-phenyl-8-(trifluoromethyl)quinoline-3-carboxamide
CAS 114350-68-4C17H11F3N2O2
Ivacaftor chemical structure, C24H28N2O3, CAS 873054-44-5
Ivacaftor
CAS 873054-44-5C24H28N2O3
N-(4-Acetylphenyl)-6-chloro-4-hydroxyquinoline-3-carboxamide chemical structure, C18H13ClN2O3, CAS 955314-07-5
N-(4-Acetylphenyl)-6-chloro-4-hydroxyquinoline-3-carboxamide
CAS 955314-07-5C18H13ClN2O3
6-Chloro-4-hydroxy-N-(4-methoxyphenyl)quinoline-3-carboxamide chemical structure, C17H13ClN2O3, CAS 86540-30-9
6-Chloro-4-hydroxy-N-(4-methoxyphenyl)quinoline-3-carboxamide
CAS 86540-30-9C17H13ClN2O3
6-Chloro-N-(4-fluorophenyl)-4-hydroxyquinoline-3-carboxamide chemical structure, C16H10ClFN2O2, CAS 955279-80-8
6-Chloro-N-(4-fluorophenyl)-4-hydroxyquinoline-3-carboxamide
CAS 955279-80-8C16H10ClFN2O2
6-Chloro-4-hydroxy-N-(3-methoxyphenyl)quinoline-3-carboxamide chemical structure, C17H13ClN2O3, CAS 955314-52-0
6-Chloro-4-hydroxy-N-(3-methoxyphenyl)quinoline-3-carboxamide
CAS 955314-52-0C17H13ClN2O3
6-Chloro-N-(3,5-difluorophenyl)-4-hydroxyquinoline-3-carboxamide chemical structure, C16H9ClF2N2O2, CAS 955280-29-2
6-Chloro-N-(3,5-difluorophenyl)-4-hydroxyquinoline-3-carboxamide
CAS 955280-29-2C16H9ClF2N2O2
6-Chloro-N-(4-chlorophenyl)-4-hydroxyquinoline-3-carboxamide chemical structure, C16H10Cl2N2O2, CAS 860205-71-6
6-Chloro-N-(4-chlorophenyl)-4-hydroxyquinoline-3-carboxamide
CAS 860205-71-6C16H10Cl2N2O2
N-(4-Acetylphenyl)-8-chloro-4-hydroxyquinoline-3-carboxamide chemical structure, C18H13ClN2O3, CAS 951971-06-5
N-(4-Acetylphenyl)-8-chloro-4-hydroxyquinoline-3-carboxamide
CAS 951971-06-5C18H13ClN2O3
8-Chloro-4-hydroxy-N-(2-methoxyphenyl)quinoline-3-carboxamide chemical structure, C17H13ClN2O3, CAS 951970-17-5
8-Chloro-4-hydroxy-N-(2-methoxyphenyl)quinoline-3-carboxamide
CAS 951970-17-5C17H13ClN2O3
8-Chloro-N-(2,5-dimethoxyphenyl)-4-hydroxyquinoline-3-carboxamide chemical structure, C18H15ClN2O4, CAS 951931-48-9
8-Chloro-N-(2,5-dimethoxyphenyl)-4-hydroxyquinoline-3-carboxamide
CAS 951931-48-9C18H15ClN2O4
8-Chloro-N-(2-cyanophenyl)-4-hydroxyquinoline-3-carboxamide chemical structure, C17H10ClN3O2, CAS 951998-30-4
8-Chloro-N-(2-cyanophenyl)-4-hydroxyquinoline-3-carboxamide
CAS 951998-30-4C17H10ClN3O2
8-Chloro-4-hydroxy-N-(2-(trifluoromethyl)phenyl)quinoline-3-carboxamide chemical structure, C17H10ClF3N2O2, CAS 951964-78-6
8-Chloro-4-hydroxy-N-(2-(trifluoromethyl)phenyl)quinoline-3-carboxamide
CAS 951964-78-6C17H10ClF3N2O2