Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 3 rings and 20 atoms

49 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 49
With full pages: 3

Scaffold SMILES

O=c1ccnc(SCc2nc(-c3ccccc3)no2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1ccnc(SCc2nc(-c3ccccc3)no2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

2-({[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-4-pyrimidinol chemical structure, C17H18N4O3S, CAS 946371-61-5

2-({[3-(4-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-4-pyrimidinol

CAS 946371-61-5C₁₇H₁₈N₄O₃S

2-({[3-(4-Ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-4-pyrimidinol chemical structure, C18H20N4O3S, CAS 946302-48-3

2-({[3-(4-Ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-4-pyrimidinol

CAS 946302-48-3C₁₈H₂₀N₄O₃S

2-({[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-4-pyrimidinol chemical structure, C17H18N4O2S, CAS 939009-58-2

2-({[3-(4-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-4-pyrimidinol

CAS 939009-58-2C₁₇H₁₈N₄O₂S

5-Ethyl-6-methyl-2-{[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfanyl}pyrimidin-4-ol chemical structure, C16H16N4O2S, CAS 933861-07-5

5-Ethyl-6-methyl-2-{[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfanyl}pyrimidin-4-ol

CAS 933861-07-5C₁₆H₁₆N₄O₂S

2-(((3-Phenyl-1,2,4-oxadiazol-5-yl)methyl)thio)-6-propylpyrimidin-4(3H)-one chemical structure, C16H16N4O2S, CAS 690683-61-5

2-(((3-Phenyl-1,2,4-oxadiazol-5-yl)methyl)thio)-6-propylpyrimidin-4(3H)-one

CAS 690683-61-5C₁₆H₁₆N₄O₂S

2-({[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one chemical structure, C15H13ClN4O2S, CAS 862789-32-0

2-({[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5,6-dimethyl-3,4-dihydropyrimidin-4-one

CAS 862789-32-0C₁₅H₁₃ClN₄O₂S

2-({[3-(3-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-3,4-dihydropyrimidin-4-one chemical structure, C17H18N4O3S, CAS 924423-23-4

2-({[3-(3-Methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-3,4-dihydropyrimidin-4-one

CAS 924423-23-4C₁₇H₁₈N₄O₃S

2-({[3-(3-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-3,4-dihydropyrimidin-4-one chemical structure, C17H18N4O2S, CAS 1226430-28-9

2-({[3-(3-Methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-propyl-3,4-dihydropyrimidin-4-one

CAS 1226430-28-9C₁₇H₁₈N₄O₂S

5-(2-Hydroxyethyl)-2-({[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-methyl-4-pyrimidinol chemical structure, C17H18N4O4S, CAS 946323-78-0

5-(2-Hydroxyethyl)-2-({[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-methyl-4-pyrimidinol

CAS 946323-78-0C₁₇H₁₈N₄O₄S

5-(2-Hydroxyethyl)-6-methyl-2-({[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)pyrimidin-4-ol chemical structure, C17H18N4O3S, CAS 946385-62-2

5-(2-Hydroxyethyl)-6-methyl-2-({[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)pyrimidin-4-ol

CAS 946385-62-2C₁₇H₁₈N₄O₃S

2-(((3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)-5-(2-hydroxyethyl)-6-methylpyrimidin-4(3H)-one chemical structure, C16H15ClN4O3S, CAS 946385-77-9

2-(((3-(2-Chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)-5-(2-hydroxyethyl)-6-methylpyrimidin-4(3H)-one

CAS 946385-77-9C₁₆H₁₅ClN₄O₃S

2-(((3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)-5-(2-hydroxyethyl)-6-methylpyrimidin-4(3H)-one chemical structure, C16H15ClN4O3S, CAS 946323-93-9

2-(((3-(3-Chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)-5-(2-hydroxyethyl)-6-methylpyrimidin-4(3H)-one

CAS 946323-93-9C₁₆H₁₅ClN₄O₃S

5-(2-Hydroxyethyl)-6-methyl-2-[({3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}methyl)sulfanyl]pyrimidin-4-ol chemical structure, C17H15F3N4O3S, CAS 946236-26-6

5-(2-Hydroxyethyl)-6-methyl-2-[({3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}methyl)sulfanyl]pyrimidin-4-ol

CAS 946236-26-6C₁₇H₁₅F₃N₄O₃S

5-(2-Hydroxyethyl)-6-methyl-2-[({3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}methyl)sulfanyl]pyrimidin-4-ol chemical structure, C17H15F3N4O3S, CAS 946270-03-7

5-(2-Hydroxyethyl)-6-methyl-2-[({3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-YL}methyl)sulfanyl]pyrimidin-4-ol

CAS 946270-03-7C₁₇H₁₅F₃N₄O₃S

2-({[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5-(2-hydroxyethyl)-6-methylpyrimidin-4-ol chemical structure, C16H15FN4O3S, CAS 946385-81-5

2-({[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5-(2-hydroxyethyl)-6-methylpyrimidin-4-ol

CAS 946385-81-5C₁₆H₁₅FN₄O₃S

2-({[3-(4-Ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-ethylpyrimidin-4-ol chemical structure, C17H18N4O3S, CAS 946295-51-8

2-({[3-(4-Ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-ethylpyrimidin-4-ol

CAS 946295-51-8C₁₇H₁₈N₄O₃S

2-({[3-(4-Ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5-(2-hydroxyethyl)-6-methyl-4-pyrimidinol chemical structure, C18H20N4O4S, CAS 946252-60-4

2-({[3-(4-Ethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5-(2-hydroxyethyl)-6-methyl-4-pyrimidinol

CAS 946252-60-4C₁₈H₂₀N₄O₄S

5-(2-Hydroxyethyl)-6-methyl-2-({[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)pyrimidin-4-ol chemical structure, C17H18N4O3S, CAS 946352-62-1

5-(2-Hydroxyethyl)-6-methyl-2-({[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)pyrimidin-4-ol

CAS 946352-62-1C₁₇H₁₈N₄O₃S

6-Propyl-2-({[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)pyrimidin-4-ol chemical structure, C19H22N4O5S, CAS 946215-54-9

6-Propyl-2-({[3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)pyrimidin-4-ol

CAS 946215-54-9C₁₉H₂₂N₄O₅S

2-({[3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-ethylpyrimidin-4-ol chemical structure, C17H18N4O4S, CAS 946328-73-0

2-({[3-(2,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-6-ethylpyrimidin-4-ol

CAS 946328-73-0C₁₇H₁₈N₄O₄S

6-Ethyl-2-[({3-[4-(methylsulfanyl)phenyl]-1,2,4-oxadiazol-5-YL}methyl)sulfanyl]pyrimidin-4-ol chemical structure, C16H16N4O2S2, CAS 946352-66-5

6-Ethyl-2-[({3-[4-(methylsulfanyl)phenyl]-1,2,4-oxadiazol-5-YL}methyl)sulfanyl]pyrimidin-4-ol

CAS 946352-66-5C₁₆H₁₆N₄O₂S₂

6-Propyl-2-[({3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)sulfanyl]-4-pyrimidinol chemical structure, C17H15F3N4O2S, CAS 1226457-78-8

6-Propyl-2-[({3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)sulfanyl]-4-pyrimidinol

CAS 1226457-78-8C₁₇H₁₅F₃N₄O₂S

6-Propyl-2-[({3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)sulfanyl]-4-pyrimidinol chemical structure, C17H15F3N4O2S, CAS 1226454-10-9

6-Propyl-2-[({3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}methyl)sulfanyl]-4-pyrimidinol

CAS 1226454-10-9C₁₇H₁₅F₃N₄O₂S

2-({[3-(2,3-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5,6-dimethylpyrimidin-4-ol chemical structure, C17H18N4O4S, CAS 1251560-32-3

2-({[3-(2,3-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-5,6-dimethylpyrimidin-4-ol

CAS 1251560-32-3C₁₇H₁₈N₄O₄S