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Murcko scaffold

Ring system with 3 rings and 21 atoms

44 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
44
With full pages
6
Scaffold SMILES

O=C(c1cccnc1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cccnc1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

[4-[(3-Bromo-4-methoxyphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C18H20BrN3O2, CAS 441743-64-2
[4-[(3-Bromo-4-methoxyphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 441743-64-2C18H20BrN3O2
[4-[(3-Nitrophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C17H18N4O3, CAS 355392-94-8
[4-[(3-Nitrophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 355392-94-8C17H18N4O3
[4-[(4-Nitrophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C17H18N4O3, CAS 333780-51-1
[4-[(4-Nitrophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 333780-51-1C17H18N4O3
[4-(2-Nitrobenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C17H18N4O3, CAS 355814-44-7
[4-(2-Nitrobenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 355814-44-7C17H18N4O3
[4-(4-Chlorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C17H18ClN3O, CAS 39640-30-7
[4-(4-Chlorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 39640-30-7C17H18ClN3O
[4-(3,4-Dimethoxybenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C19H23N3O3, CAS 355814-74-3
[4-(3,4-Dimethoxybenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 355814-74-3C19H23N3O3
[4-(3-Methoxybenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C18H21N3O2, CAS 354535-92-5
[4-(3-Methoxybenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 354535-92-5C18H21N3O2
[4-[(4-Methylphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C18H21N3O, CAS 354536-01-9
[4-[(4-Methylphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 354536-01-9C18H21N3O
[4-(2-Methoxybenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C18H21N3O2, CAS 355814-19-6
[4-(2-Methoxybenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 355814-19-6C18H21N3O2
[4-(3-Chlorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C17H18ClN3O, CAS 441743-33-5
[4-(3-Chlorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 441743-33-5C17H18ClN3O
[4-(4-Fluorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C17H18FN3O, CAS 160539-71-9
[4-(4-Fluorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 160539-71-9C17H18FN3O
[4-(3-Methylbenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C18H21N3O, CAS 444907-78-2
[4-(3-Methylbenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 444907-78-2C18H21N3O
[4-(2-Chlorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone chemical structure, C17H18ClN3O, CAS 353772-89-1
[4-(2-Chlorobenzyl)piperazin-1-yl](pyridin-3-yl)methanone
CAS 353772-89-1C17H18ClN3O
[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C18H21N3OS, CAS 506432-51-5
[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 506432-51-5C18H21N3OS
[4-[(5-Bromo-2-methoxyphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C18H20BrN3O2, CAS 355393-11-2
[4-[(5-Bromo-2-methoxyphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 355393-11-2C18H20BrN3O2
Pyridin-3-yl-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]methanone chemical structure, C20H25N3O4, CAS 123947-33-1
Pyridin-3-yl-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]methanone
CAS 123947-33-1C20H25N3O4
[4-[(3-Bromophenyl)methyl]-1-piperazinyl]-(3-pyridinyl)methanone chemical structure, C17H18BrN3O, CAS 352436-63-6
[4-[(3-Bromophenyl)methyl]-1-piperazinyl]-(3-pyridinyl)methanone
CAS 352436-63-6C17H18BrN3O
[4-[(2-Bromophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C17H18BrN3O, CAS 354536-28-0
[4-[(2-Bromophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 354536-28-0C17H18BrN3O
[4-[(4-Bromophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C17H18BrN3O, CAS 355814-79-8
[4-[(4-Bromophenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 355814-79-8C17H18BrN3O
[4-[(4-Hydroxy-3,5-dimethoxyphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone chemical structure, C19H23N3O4, CAS 500001-55-8
[4-[(4-Hydroxy-3,5-dimethoxyphenyl)methyl]piperazin-1-yl]-pyridin-3-ylmethanone
CAS 500001-55-8C19H23N3O4
(4-Benzylpiperazino)(5-bromo-3-pyridyl)methanone chemical structure, C17H18BrN3O, CAS 515866-39-4
(4-Benzylpiperazino)(5-bromo-3-pyridyl)methanone
CAS 515866-39-4C17H18BrN3O
(4-Benzylpiperazino){2-[(3,4,4-trifluoro-3-butenyl)sulfanyl]-3-pyridinyl}methanone chemical structure, C21H22F3N3OS, CAS 478081-13-9
(4-Benzylpiperazino){2-[(3,4,4-trifluoro-3-butenyl)sulfanyl]-3-pyridinyl}methanone
CAS 478081-13-9C21H22F3N3OS
(4-Benzylpiperazin-1-yl)(6-chloropyridin-3-yl)methanone chemical structure, C17H18ClN3O, CAS 385407-87-4
(4-Benzylpiperazin-1-yl)(6-chloropyridin-3-yl)methanone
CAS 385407-87-4C17H18ClN3O
(4-Benzylpiperazin-1-yl)(2-chloropyridin-3-yl)methanone chemical structure, C17H18ClN3O, CAS 544428-67-3
(4-Benzylpiperazin-1-yl)(2-chloropyridin-3-yl)methanone
CAS 544428-67-3C17H18ClN3O