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Murcko scaffold

Ring system with 3 rings and 23 atoms

148 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
148
With full pages
18
Scaffold SMILES

O=C(c1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 148 chemicals

1-(3-Fluorobenzoyl)-4-(phenylsulfonyl)piperazine chemical structure, C17H17FN2O3S, CAS 333756-73-3
1-(3-Fluorobenzoyl)-4-(phenylsulfonyl)piperazine
CAS 333756-73-3C17H17FN2O3S
1-(2-Fluorobenzoyl)-4-(phenylsulfonyl)piperazine chemical structure, C17H17FN2O3S, CAS 333756-88-0
1-(2-Fluorobenzoyl)-4-(phenylsulfonyl)piperazine
CAS 333756-88-0C17H17FN2O3S
{4-[(4-Methylphenyl)sulfonyl]piperazino}(phenyl)methanone chemical structure, C18H20N2O3S, CAS 94068-12-9
{4-[(4-Methylphenyl)sulfonyl]piperazino}(phenyl)methanone
CAS 94068-12-9C18H20N2O3S
1-(2-Methoxybenzoyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine chemical structure, C19H22N2O5S, CAS 462614-53-5
1-(2-Methoxybenzoyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine
CAS 462614-53-5C19H22N2O5S
1-Benzoyl-4-(4-methoxybenzenesulfonyl)piperazine chemical structure, C18H20N2O4S, CAS 423754-21-6
1-Benzoyl-4-(4-methoxybenzenesulfonyl)piperazine
CAS 423754-21-6C18H20N2O4S
(3,5-Dimethoxyphenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone chemical structure, C20H24N2O6S, CAS 525580-88-5
(3,5-Dimethoxyphenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone
CAS 525580-88-5C20H24N2O6S
[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone chemical structure, C20H23ClN2O6S, CAS 510713-83-4
[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
CAS 510713-83-4C20H23ClN2O6S
(4-Methoxyphenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone chemical structure, C19H22N2O5S, CAS 462097-08-1
(4-Methoxyphenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone
CAS 462097-08-1C19H22N2O5S
(3,5-Dimethoxyphenyl)-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]methanone chemical structure, C20H24N2O5S, CAS 510713-85-6
(3,5-Dimethoxyphenyl)-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]methanone
CAS 510713-85-6C20H24N2O5S
(3,4-Dimethoxyphenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone chemical structure, C20H24N2O6S, CAS 510713-91-4
(3,4-Dimethoxyphenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone
CAS 510713-91-4C20H24N2O6S
(4-Fluorophenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone chemical structure, C18H19FN2O4S, CAS 500272-25-3
(4-Fluorophenyl)-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]methanone
CAS 500272-25-3C18H19FN2O4S
[4-(Benzenesulfonyl)piperazin-1-yl]-(3,4-dimethoxyphenyl)methanone chemical structure, C19H22N2O5S, CAS 488861-98-9
[4-(Benzenesulfonyl)piperazin-1-yl]-(3,4-dimethoxyphenyl)methanone
CAS 488861-98-9C19H22N2O5S
[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-(2,6-dimethoxyphenyl)methanone chemical structure, C19H21ClN2O5S, CAS 497075-60-2
[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-(2,6-dimethoxyphenyl)methanone
CAS 497075-60-2C19H21ClN2O5S
3-[(4-Benzoylpiperazin-1-yl)sulfonyl]benzoic acid chemical structure, C18H18N2O5S, CAS 447411-92-9
3-[(4-Benzoylpiperazin-1-yl)sulfonyl]benzoic acid
CAS 447411-92-9C18H18N2O5S
(3,4-Dimethoxyphenyl)(4-(mesitylsulfonyl)piperazin-1-yl)methanone chemical structure, C22H28N2O5S, CAS 708233-34-5
(3,4-Dimethoxyphenyl)(4-(mesitylsulfonyl)piperazin-1-yl)methanone
CAS 708233-34-5C22H28N2O5S
4-[(4-Benzoyl-1-piperazinyl)sulfonyl]-2-methylphenyl methyl ether chemical structure, C19H22N2O4S, CAS 333746-09-1
4-[(4-Benzoyl-1-piperazinyl)sulfonyl]-2-methylphenyl methyl ether
CAS 333746-09-1C19H22N2O4S
(3-Methoxy-phenyl)-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone chemical structure, C19H22N2O4S, CAS 3347-09-9
(3-Methoxy-phenyl)-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone
CAS 3347-09-9C19H22N2O4S
[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-(4-methoxy-phenyl)-methanone chemical structure, C18H19ClN2O4S, CAS 333755-97-8
[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-(4-methoxy-phenyl)-methanone
CAS 333755-97-8C18H19ClN2O4S
[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-(3-fluoro-phenyl)-methanone chemical structure, C17H16ClFN2O3S, CAS 333756-05-1
[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-(3-fluoro-phenyl)-methanone
CAS 333756-05-1C17H16ClFN2O3S
4-Nitrophenyl 4-(phenylsulfonyl)piperazinyl ketone chemical structure, C17H17N3O5S, CAS 356075-73-5
4-Nitrophenyl 4-(phenylsulfonyl)piperazinyl ketone
CAS 356075-73-5C17H17N3O5S
(2,3-Dimethoxy-phenyl)-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone chemical structure, C20H24N2O5S, CAS 333756-32-4
(2,3-Dimethoxy-phenyl)-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone
CAS 333756-32-4C20H24N2O5S
(4-Benzenesulfonyl-piperazin-1-yl)-(2,3-dimethoxy-phenyl)-methanone chemical structure, C19H22N2O5S, CAS 333756-38-0
(4-Benzenesulfonyl-piperazin-1-yl)-(2,3-dimethoxy-phenyl)-methanone
CAS 333756-38-0C19H22N2O5S
[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-(3,4-dimethoxy-phenyl)-methanone chemical structure, C19H21ClN2O5S, CAS 333756-39-1
[4-(4-Chloro-benzenesulfonyl)-piperazin-1-yl]-(3,4-dimethoxy-phenyl)-methanone
CAS 333756-39-1C19H21ClN2O5S
Methyl 4-({4-[(4-methylphenyl)sulfonyl]-1-piperazinyl}carbonyl)phenyl ether chemical structure, C19H22N2O4S, CAS 3347-08-8
Methyl 4-({4-[(4-methylphenyl)sulfonyl]-1-piperazinyl}carbonyl)phenyl ether
CAS 3347-08-8C19H22N2O4S