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Murcko scaffold

1,4-Dibenzylpiperazine scaffold

617 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
617
With full pages
55
Scaffold SMILES

c1ccc(CN2CCN(Cc3ccccc3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dibenzylpiperazine page
Murcko scaffold c1ccc(CN2CCN(Cc3ccccc3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 617 chemicals

2,5-Ditert-butyl-4-[[4-[(2,5-ditert-butyl-4-hydroxyphenyl)methyl]piperazin-1-yl]methyl]phenol chemical structure, C34H54N2O2, CAS 82628-37-3
2,5-Ditert-butyl-4-[[4-[(2,5-ditert-butyl-4-hydroxyphenyl)methyl]piperazin-1-yl]methyl]phenol
CAS 82628-37-3C34H54N2O2
Diethyl benzylpiperazinomethylbenzylphosphonate chemical structure, C23H33N2O3P, CAS 157524-21-5
Diethyl benzylpiperazinomethylbenzylphosphonate
CAS 157524-21-5C23H33N2O3P
1,4-Dibenzylpiperazine chemical structure, C18H22N2, CAS 1034-11-3
1,4-Dibenzylpiperazine
CAS 1034-11-3C18H22N2
4,4'-(1,4-Piperazinediylbis(methylene))bis(2,6-bis(1,1-dimethylethyl)phenol chemical structure, C34H54N2O2, CAS 6029-54-5
4,4'-(1,4-Piperazinediylbis(methylene))bis(2,6-bis(1,1-dimethylethyl)phenol
CAS 6029-54-5C34H54N2O2
1,4-Dibenzyl-2,2-dimethylpiperazine chemical structure, C20H26N2, CAS 5435-12-1
1,4-Dibenzyl-2,2-dimethylpiperazine
CAS 5435-12-1C20H26N2
1,4-Bis(4-tert-butylbenzyl)piperazine chemical structure, C26H38N2, CAS 17768-64-8
1,4-Bis(4-tert-butylbenzyl)piperazine
CAS 17768-64-8C26H38N2
1-Benzyl-4-(2,4-dichlorobenzyl)piperazine chemical structure, C18H20Cl2N2, CAS 414884-24-5
1-Benzyl-4-(2,4-dichlorobenzyl)piperazine
CAS 414884-24-5C18H20Cl2N2
1-Benzyl-4-[(2-methoxyphenyl)methyl]piperazine chemical structure, C19H24N2O, CAS 266674-65-1
1-Benzyl-4-[(2-methoxyphenyl)methyl]piperazine
CAS 266674-65-1C19H24N2O
1-Benzyl-4-(2,3,4-trimethoxy-benzyl)-piperazine chemical structure, C21H28N2O3, CAS 207844-97-1
1-Benzyl-4-(2,3,4-trimethoxy-benzyl)-piperazine
CAS 207844-97-1C21H28N2O3
1-(3-Fluorobenzyl)-4-(3-methylbenzyl)piperazine chemical structure, C19H23FN2, CAS 438485-01-9
1-(3-Fluorobenzyl)-4-(3-methylbenzyl)piperazine
CAS 438485-01-9C19H23FN2
1-(3-Methylbenzyl)-4-[2-(trifluoromethyl)benzyl]piperazine chemical structure, C20H23F3N2, CAS 355396-12-2
1-(3-Methylbenzyl)-4-[2-(trifluoromethyl)benzyl]piperazine
CAS 355396-12-2C20H23F3N2
Piperazine, 1-(4-fluorobenzyl)-4-(2-trifluoromethylbenzyl)- chemical structure, C19H20F4N2, CAS 355396-69-9
Piperazine, 1-(4-fluorobenzyl)-4-(2-trifluoromethylbenzyl)-
CAS 355396-69-9C19H20F4N2
1-[(3-Fluorophenyl)methyl]-4-[(4-nitrophenyl)methyl]piperazine chemical structure, C18H20FN3O2, CAS 355396-22-4
1-[(3-Fluorophenyl)methyl]-4-[(4-nitrophenyl)methyl]piperazine
CAS 355396-22-4C18H20FN3O2
1-(2,4-Dimethoxybenzyl)-4-(3-fluorobenzyl)piperazine chemical structure, C20H25FN2O2, CAS 356084-62-3
1-(2,4-Dimethoxybenzyl)-4-(3-fluorobenzyl)piperazine
CAS 356084-62-3C20H25FN2O2
1-[(4-Ethylphenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine chemical structure, C21H28N2O, CAS 423752-57-2
1-[(4-Ethylphenyl)methyl]-4-[(4-methoxyphenyl)methyl]piperazine
CAS 423752-57-2C21H28N2O
1-(4-Ethoxybenzyl)-4-(3-fluorobenzyl)piperazine chemical structure, C20H25FN2O, CAS 461422-29-7
1-(4-Ethoxybenzyl)-4-(3-fluorobenzyl)piperazine
CAS 461422-29-7C20H25FN2O
1-(4-Methoxybenzyl)-4-(3-methylbenzyl)piperazine chemical structure, C20H26N2O, CAS 355820-86-9
1-(4-Methoxybenzyl)-4-(3-methylbenzyl)piperazine
CAS 355820-86-9C20H26N2O
1-(2-Methoxybenzyl)-4-(4-methylbenzyl)piperazine chemical structure, C20H26N2O, CAS 356083-58-4
1-(2-Methoxybenzyl)-4-(4-methylbenzyl)piperazine
CAS 356083-58-4C20H26N2O
1-(2,3-Dimethoxybenzyl)-4-(4-methylbenzyl)piperazine chemical structure, C21H28N2O2, CAS 356085-34-2
1-(2,3-Dimethoxybenzyl)-4-(4-methylbenzyl)piperazine
CAS 356085-34-2C21H28N2O2
1,4-Bis[(4-chlorophenyl)methyl]piperazine chemical structure, C18H20Cl2N2, CAS 441314-95-0
1,4-Bis[(4-chlorophenyl)methyl]piperazine
CAS 441314-95-0C18H20Cl2N2
1-[(4-Methoxyphenyl)methyl]-4-[(2-methylphenyl)methyl]piperazine chemical structure, C20H26N2O, CAS 356085-68-2
1-[(4-Methoxyphenyl)methyl]-4-[(2-methylphenyl)methyl]piperazine
CAS 356085-68-2C20H26N2O
1-(3-Methoxybenzyl)-4-(4-methylbenzyl)piperazine chemical structure, C20H26N2O, CAS 356086-17-4
1-(3-Methoxybenzyl)-4-(4-methylbenzyl)piperazine
CAS 356086-17-4C20H26N2O
1-(3-Methoxybenzyl)-4-(3-methylbenzyl)piperazine chemical structure, C20H26N2O, CAS 356086-46-9
1-(3-Methoxybenzyl)-4-(3-methylbenzyl)piperazine
CAS 356086-46-9C20H26N2O
1-[(3-Chlorophenyl)methyl]-4-[(4-chlorophenyl)methyl]piperazine chemical structure, C18H20Cl2N2, CAS 423153-88-2
1-[(3-Chlorophenyl)methyl]-4-[(4-chlorophenyl)methyl]piperazine
CAS 423153-88-2C18H20Cl2N2