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Murcko scaffold

1-(Benzenesulfonyl)-4-benzylpiperazine scaffold

373 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
373
With full pages
50
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Benzenesulfonyl)-4-benzylpiperazine page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 373 chemicals

1-Benzyl-4-(4-fluorophenyl)sulfonylpiperazine chemical structure, C17H19FN2O2S, CAS 305336-46-3
1-Benzyl-4-(4-fluorophenyl)sulfonylpiperazine
CAS 305336-46-3C17H19FN2O2S
1-(4-Chloro-benzyl)-4-(4-methoxy-benzenesulfonyl)-piperazine chemical structure, C18H21ClN2O3S, CAS 6037-22-5
1-(4-Chloro-benzyl)-4-(4-methoxy-benzenesulfonyl)-piperazine
CAS 6037-22-5C18H21ClN2O3S
1-(Benzenesulfonyl)-4-[(2,4-dimethoxyphenyl)methyl]piperazine chemical structure, C19H24N2O4S, CAS 428850-17-3
1-(Benzenesulfonyl)-4-[(2,4-dimethoxyphenyl)methyl]piperazine
CAS 428850-17-3C19H24N2O4S
1-(3,4-Dimethoxybenzyl)-4-[(4-fluorophenyl)sulfonyl]piperazine chemical structure, C19H23FN2O4S, CAS 428503-78-0
1-(3,4-Dimethoxybenzyl)-4-[(4-fluorophenyl)sulfonyl]piperazine
CAS 428503-78-0C19H23FN2O4S
N-[4-[4-[(4-Ethoxy-3-methoxyphenyl)methyl]piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C22H29N3O5S, CAS 428504-52-3
N-[4-[4-[(4-Ethoxy-3-methoxyphenyl)methyl]piperazin-1-yl]sulfonylphenyl]acetamide
CAS 428504-52-3C22H29N3O5S
1-Benzyl-4-(2-methoxy-5-methyl-benzenesulfonyl)-piperazine chemical structure, C19H24N2O3S, CAS 5367-54-4
1-Benzyl-4-(2-methoxy-5-methyl-benzenesulfonyl)-piperazine
CAS 5367-54-4C19H24N2O3S
1-Benzyl-4-(4-methoxyphenyl)sulfonylpiperazine chemical structure, C18H22N2O3S, CAS 321531-79-7
1-Benzyl-4-(4-methoxyphenyl)sulfonylpiperazine
CAS 321531-79-7C18H22N2O3S
1-Benzyl-4-[(4-methylphenyl)sulfonyl]piperazine chemical structure, C18H22N2O2S, CAS 95558-32-0
1-Benzyl-4-[(4-methylphenyl)sulfonyl]piperazine
CAS 95558-32-0C18H22N2O2S
1-(Benzenesulfonyl)-4-benzylpiperazine chemical structure, C17H20N2O2S, CAS 107785-25-1
1-(Benzenesulfonyl)-4-benzylpiperazine
CAS 107785-25-1C17H20N2O2S
1-[(4-Fluorophenyl)sulfonyl]-4-(2-methylbenzyl)piperazine chemical structure, C18H21FN2O2S, CAS 428842-96-0
1-[(4-Fluorophenyl)sulfonyl]-4-(2-methylbenzyl)piperazine
CAS 428842-96-0C18H21FN2O2S
1-(3-Fluorobenzyl)-4-[(4-methylphenyl)sulfonyl]piperazine chemical structure, C18H21FN2O2S, CAS 428505-10-6
1-(3-Fluorobenzyl)-4-[(4-methylphenyl)sulfonyl]piperazine
CAS 428505-10-6C18H21FN2O2S
1-(4-Methoxybenzyl)-4-(phenylsulfonyl)piperazine chemical structure, C18H22N2O3S, CAS 428843-91-8
1-(4-Methoxybenzyl)-4-(phenylsulfonyl)piperazine
CAS 428843-91-8C18H22N2O3S
1-[(4-Fluorophenyl)sulfonyl]-4-(3-methylbenzyl)piperazine chemical structure, C18H21FN2O2S, CAS 428832-43-3
1-[(4-Fluorophenyl)sulfonyl]-4-(3-methylbenzyl)piperazine
CAS 428832-43-3C18H21FN2O2S
1-[(4-Fluorophenyl)sulfonyl]-4-(4-methylbenzyl)piperazine chemical structure, C18H21FN2O2S, CAS 461408-73-1
1-[(4-Fluorophenyl)sulfonyl]-4-(4-methylbenzyl)piperazine
CAS 461408-73-1C18H21FN2O2S
1-[(4-Fluorophenyl)methyl]-4-(phenylsulfonyl)piperazine chemical structure, C17H19FN2O2S, CAS 305336-48-5
1-[(4-Fluorophenyl)methyl]-4-(phenylsulfonyl)piperazine
CAS 305336-48-5C17H19FN2O2S
1-(4-Fluorobenzyl)-4-[(4-methylphenyl)sulfonyl]piperazine chemical structure, C18H21FN2O2S, CAS 425390-01-8
1-(4-Fluorobenzyl)-4-[(4-methylphenyl)sulfonyl]piperazine
CAS 425390-01-8C18H21FN2O2S
1-(2-Methylbenzyl)-4-[(4-methylphenyl)sulfonyl]piperazine chemical structure, C19H24N2O2S, CAS 423739-87-1
1-(2-Methylbenzyl)-4-[(4-methylphenyl)sulfonyl]piperazine
CAS 423739-87-1C19H24N2O2S
1-(3-Fluorobenzyl)-4-(phenylsulfonyl)piperazine chemical structure, C17H19FN2O2S, CAS 333757-90-7
1-(3-Fluorobenzyl)-4-(phenylsulfonyl)piperazine
CAS 333757-90-7C17H19FN2O2S
1-(4-Methylbenzyl)-4-(phenylsulfonyl)piperazine chemical structure, C18H22N2O2S, CAS 423743-00-4
1-(4-Methylbenzyl)-4-(phenylsulfonyl)piperazine
CAS 423743-00-4C18H22N2O2S
1-Benzyl-4-[(3,4-dimethylphenyl)sulfonyl]piperazine chemical structure, C19H24N2O2S, CAS 364737-75-7
1-Benzyl-4-[(3,4-dimethylphenyl)sulfonyl]piperazine
CAS 364737-75-7C19H24N2O2S
1-(2-Methoxybenzyl)-4-(phenylsulfonyl)piperazine chemical structure, C18H22N2O3S, CAS 425389-96-4
1-(2-Methoxybenzyl)-4-(phenylsulfonyl)piperazine
CAS 425389-96-4C18H22N2O3S
1-(3-Methoxybenzyl)-4-(phenylsulfonyl)piperazine chemical structure, C18H22N2O3S, CAS 462601-54-3
1-(3-Methoxybenzyl)-4-(phenylsulfonyl)piperazine
CAS 462601-54-3C18H22N2O3S
1-(2-Fluorobenzyl)-4-(phenylsulfonyl)piperazine chemical structure, C17H19FN2O2S, CAS 425392-00-3
1-(2-Fluorobenzyl)-4-(phenylsulfonyl)piperazine
CAS 425392-00-3C17H19FN2O2S
1-Benzyl-4-(3-fluorophenyl)sulfonylpiperazine chemical structure, C17H19FN2O2S, CAS 667912-09-6
1-Benzyl-4-(3-fluorophenyl)sulfonylpiperazine
CAS 667912-09-6C17H19FN2O2S