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Murcko scaffold

Ring system with 3 rings and 19 atoms

81 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
81
With full pages
4
Scaffold SMILES

O=C(Nc1nc(-c2ccccc2)cs1)c1ccn[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nc(-c2ccccc2)cs1)c1ccn[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 81 chemicals

3-tert-Butyl-N-[4-(4-methoxyphenyl)-5-methyl-1,3-thiazol-2-yl]-1-methylpyrazole-5-carboxamide chemical structure, C20H24N4O2S, CAS 606117-97-9
3-tert-Butyl-N-[4-(4-methoxyphenyl)-5-methyl-1,3-thiazol-2-yl]-1-methylpyrazole-5-carboxamide
CAS 606117-97-9C20H24N4O2S
1-Methyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]-4-nitropyrazole-3-carboxamide chemical structure, C16H15N5O3S, CAS 512826-19-6
1-Methyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]-4-nitropyrazole-3-carboxamide
CAS 512826-19-6C16H15N5O3S
N-[4-(2,5-Dimethoxyphenyl)-1,3-thiazol-2-yl]-1-methyl-4-nitropyrazole-3-carboxamide chemical structure, C16H15N5O5S, CAS 512826-50-5
N-[4-(2,5-Dimethoxyphenyl)-1,3-thiazol-2-yl]-1-methyl-4-nitropyrazole-3-carboxamide
CAS 512826-50-5C16H15N5O5S
N-[4-(3,4-Dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-methyl-4-nitropyrazole-3-carboxamide chemical structure, C17H17N5O3S, CAS 512825-24-0
N-[4-(3,4-Dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-methyl-4-nitropyrazole-3-carboxamide
CAS 512825-24-0C17H17N5O3S
4-Bromo-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1,5-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C18H19BrN4OS, CAS 512824-23-6
4-Bromo-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1,5-dimethyl-1H-pyrazole-3-carboxamide
CAS 512824-23-6C18H19BrN4OS
4-Chloro-1-ethyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]pyrazole-3-carboxamide chemical structure, C17H17ClN4OS, CAS 512817-88-8
4-Chloro-1-ethyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]pyrazole-3-carboxamide
CAS 512817-88-8C17H17ClN4OS
1-Ethyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]-4-nitropyrazole-3-carboxamide chemical structure, C17H17N5O3S, CAS 512817-82-2
1-Ethyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]-4-nitropyrazole-3-carboxamide
CAS 512817-82-2C17H17N5O3S
4-Bromo-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-ethyl-1H-pyrazole-5-carboxamide chemical structure, C18H19BrN4OS, CAS 512816-98-7
4-Bromo-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-ethyl-1H-pyrazole-5-carboxamide
CAS 512816-98-7C18H19BrN4OS
4-Bromo-2-ethyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]pyrazole-3-carboxamide chemical structure, C17H17BrN4OS, CAS 512816-21-6
4-Bromo-2-ethyl-N-[5-methyl-4-(4-methylphenyl)-1,3-thiazol-2-yl]pyrazole-3-carboxamide
CAS 512816-21-6C17H17BrN4OS
4-Chloro-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-ethyl-1H-pyrazole-3-carboxamide chemical structure, C18H19ClN4OS, CAS 512815-77-9
4-Chloro-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-ethyl-1H-pyrazole-3-carboxamide
CAS 512815-77-9C18H19ClN4OS
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-methyl-4-nitropyrazole-3-carboxamide chemical structure, C14H10ClN5O3S, CAS 354577-13-2
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-methyl-4-nitropyrazole-3-carboxamide
CAS 354577-13-2C14H10ClN5O3S
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C14H11ClN4OS, CAS 488821-79-0
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-1-methyl-1H-pyrazole-5-carboxamide
CAS 488821-79-0C14H11ClN4OS
4-Bromo-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-methylpyrazole-3-carboxamide chemical structure, C17H17BrN4OS, CAS 512812-86-1
4-Bromo-N-[4-(3,4-dimethylphenyl)-5-methyl-1,3-thiazol-2-yl]-1-methylpyrazole-3-carboxamide
CAS 512812-86-1C17H17BrN4OS
4-Bromo-N-[4-[4-(difluoromethoxy)phenyl]-1,3-thiazol-2-yl]-1H-pyrazole-5-carboxamide chemical structure, C14H9BrF2N4O2S, CAS 1005590-41-9
4-Bromo-N-[4-[4-(difluoromethoxy)phenyl]-1,3-thiazol-2-yl]-1H-pyrazole-5-carboxamide
CAS 1005590-41-9C14H9BrF2N4O2S
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-methoxy-4-nitro-1H-pyrazole-5-carboxamide chemical structure, C14H9Cl2N5O4S, CAS 515151-14-1
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-methoxy-4-nitro-1H-pyrazole-5-carboxamide
CAS 515151-14-1C14H9Cl2N5O4S
N-[4-(2,4-Difluorophenyl)-1,3-thiazol-2-yl]-4-nitro-1H-pyrazole-3-carboxamide chemical structure, C13H7F2N5O3S, CAS 1005564-79-3
N-[4-(2,4-Difluorophenyl)-1,3-thiazol-2-yl]-4-nitro-1H-pyrazole-3-carboxamide
CAS 1005564-79-3C13H7F2N5O3S
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-1,5-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C15H13FN4OS, CAS 1013770-60-9
N-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-1,5-dimethyl-1H-pyrazole-3-carboxamide
CAS 1013770-60-9C15H13FN4OS
N-(4-(4-Fluorophenyl)thiazol-2-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide chemical structure, C15H13FN4OS, CAS 1013771-54-4
N-(4-(4-Fluorophenyl)thiazol-2-yl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
CAS 1013771-54-4C15H13FN4OS
1,5-Dimethyl-N-(4-phenylthiazol-2-yl)-1H-pyrazole-3-carboxamide chemical structure, C15H14N4OS, CAS 1013769-05-5
1,5-Dimethyl-N-(4-phenylthiazol-2-yl)-1H-pyrazole-3-carboxamide
CAS 1013769-05-5C15H14N4OS
N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C16H16N4O2S, CAS 1013769-35-1
N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide
CAS 1013769-35-1C16H16N4O2S
N-(4-(3,4-Dimethylphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C17H18N4OS, CAS 1013770-30-3
N-(4-(3,4-Dimethylphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide
CAS 1013770-30-3C17H18N4OS
N-(4-(3,4-Dimethoxyphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C17H18N4O3S, CAS 1013771-12-4
N-(4-(3,4-Dimethoxyphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide
CAS 1013771-12-4C17H18N4O3S
Ethyl 2-(1,5-dimethyl-1H-pyrazole-3-carboxamido)-4-phenylthiazole-5-carboxylate chemical structure, C18H18N4O3S, CAS 1013773-15-3
Ethyl 2-(1,5-dimethyl-1H-pyrazole-3-carboxamido)-4-phenylthiazole-5-carboxylate
CAS 1013773-15-3C18H18N4O3S
N-(4-(2,4-Dimethoxyphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide chemical structure, C17H18N4O3S, CAS 1013795-17-9
N-(4-(2,4-Dimethoxyphenyl)thiazol-2-yl)-1,5-dimethyl-1H-pyrazole-3-carboxamide
CAS 1013795-17-9C17H18N4O3S