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Murcko scaffold

Ring system with 3 rings and 20 atoms

22 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 22
With full pages: 6

Scaffold SMILES

O=C(CNc1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CNc1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]methanesulfonamide chemical structure, C18H19ClN2O3S, CAS 425666-42-8

N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]methanesulfonamide

CAS 425666-42-8C₁₈H₁₉ClN₂O₃S

N-(2-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide chemical structure, C18H19ClN2O3S, CAS 355823-85-7

N-(2-Chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide

CAS 355823-85-7C₁₈H₁₉ClN₂O₃S

N-(3-Chloro-4-methylphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]methanesulfonamide chemical structure, C19H21ClN2O3S, CAS 426223-44-1

N-(3-Chloro-4-methylphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]methanesulfonamide

CAS 426223-44-1C₁₉H₂₁ClN₂O₃S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(3,4-dimethoxyphenyl)methanesulfonamide chemical structure, C20H24N2O5S, CAS 442566-74-7

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(3,4-dimethoxyphenyl)methanesulfonamide

CAS 442566-74-7C₂₀H₂₄N₂O₅S

N-(2,3-Dichlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide chemical structure, C18H18Cl2N2O3S, CAS 432531-45-8

N-(2,3-Dichlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide

CAS 432531-45-8C₁₈H₁₈Cl₂N₂O₃S

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(3-fluorophenyl)methanesulfonamide chemical structure, C18H19FN2O3S, CAS 640716-87-6

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(3-fluorophenyl)methanesulfonamide

CAS 640716-87-6C₁₈H₁₉FN₂O₃S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(2,5-dimethoxyphenyl)methanesulfonamide chemical structure, C20H24N2O5S, CAS 700855-61-4

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(2,5-dimethoxyphenyl)methanesulfonamide

CAS 700855-61-4C₂₀H₂₄N₂O₅S

N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl)-N-(2-ethylphenyl)methanesulfonamide chemical structure, C20H24N2O3S, CAS 799259-73-7

N-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl)-N-(2-ethylphenyl)methanesulfonamide

CAS 799259-73-7C₂₀H₂₄N₂O₃S

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(4-ethoxyphenyl)methanesulfonamide chemical structure, C20H24N2O4S, CAS 332034-59-0

N-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-N-(4-ethoxyphenyl)methanesulfonamide

CAS 332034-59-0C₂₀H₂₄N₂O₄S

N-(3,5-Dichlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide chemical structure, C18H18Cl2N2O3S, CAS 443668-68-6

N-(3,5-Dichlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide

CAS 443668-68-6C₁₈H₁₈Cl₂N₂O₃S

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(2-ethoxyphenyl)methanesulfonamide chemical structure, C20H24N2O4S, CAS 335208-37-2

N-[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-N-(2-ethoxyphenyl)methanesulfonamide

CAS 335208-37-2C₂₀H₂₄N₂O₄S

N-(5-Chloro-2-methoxyphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]methanesulfonamide chemical structure, C19H21ClN2O4S, CAS 425676-37-5

N-(5-Chloro-2-methoxyphenyl)-N-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]methanesulfonamide

CAS 425676-37-5C₁₉H₂₁ClN₂O₄S

N-[1-(3,4-Dihydro-1H-isoquinolin-2-yl)-1-oxopropan-2-yl]-N-(4-methylphenyl)methanesulfonamide chemical structure, C20H24N2O3S, CAS 1008185-95-2

N-[1-(3,4-Dihydro-1H-isoquinolin-2-yl)-1-oxopropan-2-yl]-N-(4-methylphenyl)methanesulfonamide

CAS 1008185-95-2C₂₀H₂₄N₂O₃S

N-(4-Chlorophenyl)-N-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-1-oxopropan-2-yl]methanesulfonamide chemical structure, C19H21ClN2O3S, CAS 1009728-75-9

N-(4-Chlorophenyl)-N-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-1-oxopropan-2-yl]methanesulfonamide

CAS 1009728-75-9C₁₉H₂₁ClN₂O₃S

[[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-(4-methoxyphenyl)amino]acetic acid chemical structure, C20H22N2O4, CAS 1142205-74-0

[[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-(4-methoxyphenyl)amino]acetic acid

CAS 1142205-74-0C₂₀H₂₂N₂O₄

[[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-(phenyl)amino]acetic acid chemical structure, C19H20N2O3, CAS 1142211-87-7

[[2-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]-(phenyl)amino]acetic acid

CAS 1142211-87-7C₁₉H₂₀N₂O₃

2-((4-Chlorophenyl)amino)-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one chemical structure, C17H17ClN2O, CAS 1082816-22-5

2-((4-Chlorophenyl)amino)-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one

CAS 1082816-22-5C₁₇H₁₇ClN₂O

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(3-methylphenyl)methanesulfonamide chemical structure, C20H24N2O3S, CAS 1268965-55-4

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(3-methylphenyl)methanesulfonamide

CAS 1268965-55-4C₂₀H₂₄N₂O₃S

N-(2,4-Difluorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide chemical structure, C18H18F2N2O3S, CAS 1269104-62-2

N-(2,4-Difluorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide

CAS 1269104-62-2C₁₈H₁₈F₂N₂O₃S

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(3-methoxyphenyl)methanesulfonamide chemical structure, C20H24N2O4S, CAS 1268966-06-8

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(3-methoxyphenyl)methanesulfonamide

CAS 1268966-06-8C₂₀H₂₄N₂O₄S

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(3-fluorophenyl)methanesulfonamide chemical structure, C19H21FN2O3S, CAS 1309093-14-8

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(3-fluorophenyl)methanesulfonamide

CAS 1309093-14-8C₁₉H₂₁FN₂O₃S

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(4-fluorophenyl)methanesulfonamide chemical structure, C19H21FN2O3S, CAS 1008436-40-5

N-[1-(3,4-Dihydroisoquinolin-2(1H)-yl)-1-oxopropan-2-yl]-N-(4-fluorophenyl)methanesulfonamide

CAS 1008436-40-5C₁₉H₂₁FN₂O₃S