Murcko scaffold
Benzamide, N-2-thienyl- scaffold
930 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 930
- With full pages
- 52
Scaffold SMILES
O=C(Nc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 481 to 528 of 930 chemicals
![Dipropan-2-yl 5-[(2,4-dichlorobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C20H21Cl2NO5S, CAS 420090-99-9](/s/XSJFOWQVCNRCHK-UHFFFAOYSA-N.svg)
Dipropan-2-yl 5-[(2,4-dichlorobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 420090-99-9C20H21Cl2NO5S
![Dimethyl 3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate chemical structure, C16H14N2O7S, CAS 420090-57-9](/s/PKSBWIPBIWBNMU-UHFFFAOYSA-N.svg)
Dimethyl 3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate
CAS 420090-57-9C16H14N2O7S
![Methyl 4-ethyl-5-methyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C16H16N2O5S, CAS 557778-72-0](/s/JZAXIBZQFBWVNI-UHFFFAOYSA-N.svg)
Methyl 4-ethyl-5-methyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 557778-72-0C16H16N2O5S
Isopropyl 4-(aminocarbonyl)-5-({4-nitro-3-methylbenzoyl}amino)-3-methyl-2-thiophenecarboxylate
CAS 352684-61-8C18H19N3O6S
Ethyl 5-carbamoyl-4-methyl-2-(perfluorobenzamido)thiophene-3-carboxylate
CAS 551907-64-3C16H11F5N2O4S
![Propan-2-yl 4-carbamoyl-3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2-carboxylate chemical structure, C17H17N3O6S, CAS 424812-50-0](/s/UGSZMBVGVVUBOO-UHFFFAOYSA-N.svg)
Propan-2-yl 4-carbamoyl-3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2-carboxylate
CAS 424812-50-0C17H17N3O6S
Methyl 2-(3-fluorobenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 352689-57-7C15H14FNO3S
![Methyl 4,5-dimethyl-2-{[(pentafluorophenyl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C15H10F5NO3S, CAS 425372-78-7](/s/NMCBWSOVJBNDCC-UHFFFAOYSA-N.svg)
Methyl 4,5-dimethyl-2-{[(pentafluorophenyl)carbonyl]amino}thiophene-3-carboxylate
CAS 425372-78-7C15H10F5NO3S
![Propan-2-yl 5-(diethylcarbamoyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]thiophene-3-carboxylate chemical structure, C21H21F5N2O4S, CAS 424811-30-3](/s/YDJFOHPBOGLZIJ-UHFFFAOYSA-N.svg)
Propan-2-yl 5-(diethylcarbamoyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]thiophene-3-carboxylate
CAS 424811-30-3C21H21F5N2O4S
![Methyl 5-(diethylcarbamoyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]thiophene-3-carboxylate chemical structure, C19H17F5N2O4S, CAS 540792-01-6](/s/DXTHPYYSWQECQS-UHFFFAOYSA-N.svg)
Methyl 5-(diethylcarbamoyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]thiophene-3-carboxylate
CAS 540792-01-6C19H17F5N2O4S
![Ethyl 4-carbamoyl-3-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]thiophene-2-carboxylate chemical structure, C19H22N2O7S, CAS 438619-24-0](/s/OFBFSUZBQDEUEJ-UHFFFAOYSA-N.svg)
Ethyl 4-carbamoyl-3-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]thiophene-2-carboxylate
CAS 438619-24-0C19H22N2O7S
![Dimethyl 5-[(2-chloro-4-nitrobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C16H13ClN2O7S, CAS 438454-62-7](/s/JMTLDLUNRKYYKY-UHFFFAOYSA-N.svg)
Dimethyl 5-[(2-chloro-4-nitrobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 438454-62-7C16H13ClN2O7S
![Isopropyl 4,5-dimethyl-2-[(4-methylbenzoyl)amino]-3-thiophenecarboxylate chemical structure, C18H21NO3S, CAS 541544-77-8](/s/HUTXFWXGCASWPT-UHFFFAOYSA-N.svg)
Isopropyl 4,5-dimethyl-2-[(4-methylbenzoyl)amino]-3-thiophenecarboxylate
CAS 541544-77-8C18H21NO3S
![Ethyl 4,5-dimethyl-2-{[(pentafluorophenyl)carbonyl]amino}thiophene-3-carboxylate chemical structure, C16H12F5NO3S, CAS 544416-15-1](/s/XVVSNPSQQGOIRH-UHFFFAOYSA-N.svg)
Ethyl 4,5-dimethyl-2-{[(pentafluorophenyl)carbonyl]amino}thiophene-3-carboxylate
CAS 544416-15-1C16H12F5NO3S
![Methyl 5-ethyl-2-[(3-propoxybenzoyl)amino]-3-thiophenecarboxylate chemical structure, C18H21NO4S, CAS 350989-10-5](/s/IOIZBUMOEFNMLA-UHFFFAOYSA-N.svg)
Methyl 5-ethyl-2-[(3-propoxybenzoyl)amino]-3-thiophenecarboxylate
CAS 350989-10-5C18H21NO4S
![2-[(4-Butoxybenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C19H24N2O3S, CAS 350989-23-0](/s/VCLLYKIUKWUMRK-UHFFFAOYSA-N.svg)
2-[(4-Butoxybenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 350989-23-0C19H24N2O3S
![Methyl 2-[(3-ethoxybenzoyl)amino]-5-methylthiophene-3-carboxylate chemical structure, C16H17NO4S, CAS 6131-42-6](/s/JSUBKFDNNPCCLP-UHFFFAOYSA-N.svg)
Methyl 2-[(3-ethoxybenzoyl)amino]-5-methylthiophene-3-carboxylate
CAS 6131-42-6C16H17NO4S
![Methyl 2-[(4-butoxybenzoyl)amino]-5-propyl-3-thiophenecarboxylate chemical structure, C20H25NO4S, CAS 444908-48-9](/s/AKESIEFESIEPPZ-UHFFFAOYSA-N.svg)
Methyl 2-[(4-butoxybenzoyl)amino]-5-propyl-3-thiophenecarboxylate
CAS 444908-48-9C20H25NO4S
![Methyl 2-[(3-propoxybenzoyl)amino]-5-propylthiophene-3-carboxylate chemical structure, C19H23NO4S, CAS 350999-23-4](/s/RHOPALQJOICYAY-UHFFFAOYSA-N.svg)
Methyl 2-[(3-propoxybenzoyl)amino]-5-propylthiophene-3-carboxylate
CAS 350999-23-4C19H23NO4S
![Methyl 4,5-dimethyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxylate chemical structure, C18H21NO6S, CAS 447449-24-3](/s/JXDNEFACBNHSHB-UHFFFAOYSA-N.svg)
Methyl 4,5-dimethyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxylate
CAS 447449-24-3C18H21NO6S
![Isopropyl 4-ethyl-2-[(3-methoxybenzoyl)amino]-5-methyl-3-thiophenecarboxylate chemical structure, C19H23NO4S, CAS 545347-66-8](/s/OMZSVTWTIBPCEP-UHFFFAOYSA-N.svg)
Isopropyl 4-ethyl-2-[(3-methoxybenzoyl)amino]-5-methyl-3-thiophenecarboxylate
CAS 545347-66-8C19H23NO4S
Methyl 2-(2-bromobenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 353781-79-0C15H14BrNO3S
Diethyl 3-methyl-5-(perfluorobenzamido)thiophene-2,4-dicarboxylate
CAS 545339-40-0C18H14F5NO5S
![5-[(2-Chloro-4,5-difluorobenzoyl)amino]-4-cyano-N,N-diethyl-3-methylthiophene-2-carboxamide chemical structure, C18H16ClF2N3O2S, CAS 777874-18-7](/s/XQJIILKZDSRKAX-UHFFFAOYSA-N.svg)
5-[(2-Chloro-4,5-difluorobenzoyl)amino]-4-cyano-N,N-diethyl-3-methylthiophene-2-carboxamide
CAS 777874-18-7C18H16ClF2N3O2S
- Propan-2-yl 4-cyano-5-[(4-methoxy-3-nitrobenzoyl)amino]-3-methylthiophene-2-carboxylate777877-99-3C18H17N3O6S
- 2-O-Ethyl 4-O-methyl 3-methyl-5-[(2-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate717873-79-5C17H16N2O7S
- 2-[(3,5-Dinitrobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxamide5524-15-2C14H12N4O6S
- 2-{[3-(Ethoxycarbonyl)-4,5-dimethylthiophen-2-yl]carbamoyl}-6-nitrobenzoic acid5564-63-6C17H16N2O7S
- 4-Ethyl 2-methyl 3-methyl-5-{[(2-methylphenyl)carbonyl]amino}thiophene-2,4-dicarboxylate433691-58-8C18H19NO5S
- Methyl 5-{[(2-chloro-4-nitrophenyl)carbonyl]amino}-4-cyano-3-methylthiophene-2-carboxylate461403-60-1C15H10ClN3O5S
- Ethyl 5-(3,5-dimethoxybenzamido)-3-methylthiophene-2-carboxylate380451-37-6C17H19NO5S
- Ethyl 5-(4-cyanobenzamido)-3-methylthiophene-2-carboxylate380451-46-7C16H14N2O3S
- Ethyl 5-(3,4-dimethylbenzamido)-3-methylthiophene-2-carboxylate380569-21-1C17H19NO3S
- Ethyl 5-(2,4-dimethoxybenzamido)-3-methylthiophene-2-carboxylate477567-52-5C17H19NO5S
- Ethyl 5-(2,6-dimethoxybenzamido)-3-methylthiophene-2-carboxylate477568-13-1C17H19NO5S
- 1 suppliersN-(3-Cyanothiophen-2-yl)-3-methoxybenzamide721909-43-9C13H10N2O2S
- 2-(3-Methoxybenzamido)thiophene-3-carboxamide722471-17-2C13H12N2O3S
- 2-(3-(Trifluoromethyl)benzamido)thiophene-3-carboxamide731839-72-8C13H9F3N2O2S
- Ethyl 5-(3-chlorobenzamido)-3-methylthiophene-2-carboxylate477567-34-3C15H14ClNO3S
- Ethyl 3-methyl-5-(4-methylbenzamido)thiophene-2-carboxylate477567-30-9C16H17NO3S
- Ethyl 5-(3-methoxybenzamido)-3-methylthiophene-2-carboxylate477567-50-3C16H17NO4S
- Ethyl 4-cyano-5-(4-fluorobenzamido)-3-methylthiophene-2-carboxylate570417-26-4C16H13FN2O3S
- Propan-2-yl 5-{[(5-bromo-2-chlorophenyl)carbonyl]amino}-4-cyano-3-methylthiophene-2-carboxylate777872-83-0C17H14BrClN2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-5-methyl-, 2-hydroxyethyl ester78033-82-6C15H15NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-hydroxyethyl ester78033-83-7C16H17NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(dimethylamino)ethyl ester78033-84-8C18H22N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(diethylamino)ethyl ester78033-85-9C20H26N2O3S
- 2-Thiopheneacetic acid, 5-benzamido-4-carboxy-3-methyl-105522-85-8C15H13NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals
O=C(Nc1ccccc1)C1CCCC143 chemicals