Murcko scaffold
Benzamide, N-2-thienyl- scaffold
930 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 930
- With full pages
- 52
Scaffold SMILES
O=C(Nc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 385 to 432 of 930 chemicals
![2-[(3-Bromobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H15BrN2O2S, CAS 6101-53-7](/s/UIMQSNCAOHIQLW-UHFFFAOYSA-N.svg)
2-[(3-Bromobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 6101-53-7C15H15BrN2O2S
![Dipropan-2-yl 5-[(3-methoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C21H25NO6S, CAS 6104-88-7](/s/KFGSCJWUKUHYQN-UHFFFAOYSA-N.svg)
Dipropan-2-yl 5-[(3-methoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 6104-88-7C21H25NO6S
![4-Ethyl 2-methyl 5-{[(3-methoxyphenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate chemical structure, C18H19NO6S, CAS 443122-00-7](/s/OCHXLHADOHAIGB-UHFFFAOYSA-N.svg)
4-Ethyl 2-methyl 5-{[(3-methoxyphenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate
CAS 443122-00-7C18H19NO6S
![Ethyl 2-[(4-chloro-2-nitrobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H15ClN2O5S, CAS 424804-91-1](/s/DAVRSIZSORRPIT-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-chloro-2-nitrobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 424804-91-1C16H15ClN2O5S
Ethyl 2-benzamido-4-ethyl-5-methylthiophene-3-carboxylate
CAS 551902-07-9C17H19NO3S
N-(4,5-Dimethylthiophen-2-yl)-4-methoxybenzamide
CAS 690641-59-9C14H15NO2S
Methyl 2-(3-chlorobenzamido)thiophene-3-carboxylate
CAS 338750-43-9C13H10ClNO3S
![Dimethyl 5-[(3-chlorobenzoyl)amino]-3-(2-methoxy-2-oxoethyl)-2,4-thiophenedicarboxylate chemical structure, C18H16ClNO7S, CAS 338393-17-2](/s/KUOVJIHRFSGSBO-UHFFFAOYSA-N.svg)
Dimethyl 5-[(3-chlorobenzoyl)amino]-3-(2-methoxy-2-oxoethyl)-2,4-thiophenedicarboxylate
CAS 338393-17-2C18H16ClNO7S
Dimethyl 5-(benzoylamino)-3-(2-methoxy-2-oxoethyl)-2,4-thiophenedicarboxylate
CAS 338393-19-4C18H17NO7S
![Dimethyl 3-(2-methoxy-2-oxoethyl)-5-[(3-methylbenzoyl)amino]-2,4-thiophenedicarboxylate chemical structure, C19H19NO7S, CAS 338393-34-3](/s/KNTVQRPOKJYYIQ-UHFFFAOYSA-N.svg)
Dimethyl 3-(2-methoxy-2-oxoethyl)-5-[(3-methylbenzoyl)amino]-2,4-thiophenedicarboxylate
CAS 338393-34-3C19H19NO7S
![Diethyl 5-[(5-chloro-2-nitrobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C18H17ClN2O7S, CAS 330215-36-6](/s/GPHYMBDVSFTKTF-UHFFFAOYSA-N.svg)
Diethyl 5-[(5-chloro-2-nitrobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 330215-36-6C18H17ClN2O7S
Diethyl 5-((4-chloro-3-nitrobenzoyl)amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 301682-02-0C18H17ClN2O7S
2-Benzamido-N-(3-hydroxypropyl)-4,5-dimethylthiophene-3-carboxamide
CAS 405916-24-7C17H20N2O3S
2-Benzamido-N-(2-hydroxyethyl)-4,5-dimethylthiophene-3-carboxamide
CAS 326888-16-8C16H18N2O3S
Ethyl 2-(3,5-dinitrobenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 296263-73-5C16H15N3O7S
Diethyl 5-((4-tert-butylbenzoyl)amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 303792-46-3C22H27NO5S
![Diethyl 5-[(2-chloro-5-nitrobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C18H17ClN2O7S, CAS 311764-94-0](/s/JDQROWJXNBLSFG-UHFFFAOYSA-N.svg)
Diethyl 5-[(2-chloro-5-nitrobenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 311764-94-0C18H17ClN2O7S
![Diethyl 3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate chemical structure, C18H18N2O7S, CAS 312944-57-3](/s/HIPWCVAWMRWHPC-UHFFFAOYSA-N.svg)
Diethyl 3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate
CAS 312944-57-3C18H18N2O7S
Ethyl 4-cyano-3-methyl-5-(4-methylbenzamido)thiophene-2-carboxylate
CAS 443122-60-9C17H16N2O3S
Methyl 4-(aminocarbonyl)-5-({3-nitrobenzoyl}amino)-3-methyl-2-thiophenecarboxylate
CAS 353471-91-7C15H13N3O6S
![Ethyl 5-carbamoyl-4-methyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C16H15N3O6S, CAS 420092-11-1](/s/CLPMZGYDWDYZGA-UHFFFAOYSA-N.svg)
Ethyl 5-carbamoyl-4-methyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 420092-11-1C16H15N3O6S
![Ethyl 5-(diethylcarbamoyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]thiophene-3-carboxylate chemical structure, C20H19F5N2O4S, CAS 328261-29-6](/s/ODKVGHISWSIBDM-UHFFFAOYSA-N.svg)
Ethyl 5-(diethylcarbamoyl)-4-methyl-2-[(2,3,4,5,6-pentafluorobenzoyl)amino]thiophene-3-carboxylate
CAS 328261-29-6C20H19F5N2O4S
Diisopropyl 5-({2-nitrobenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 419558-44-4C20H22N2O7S
Diisopropyl 5-({2-chloro-5-nitrobenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate
CAS 550353-65-6C20H21ClN2O7S
- Ethyl 5-carbamoyl-2-[(2-chloro-5-nitrobenzoyl)amino]-4-methylthiophene-3-carboxylate557781-91-6C16H14ClN3O6S
- 5-[(3,5-Dinitrobenzoyl)amino]-2-N,2-N-diethyl-3-methylthiophene-2,4-dicarboxamide445249-57-0C18H19N5O7S
- Dimethyl 3-methyl-5-[(3-methyl-4-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate540533-00-4C17H16N2O7S
- Diisopropyl 5-({4-nitro-3-methylbenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate445250-56-6C21H24N2O7S
- Diisopropyl 5-[(4-chlorobenzoyl)amino]-3-methyl-2,4-thiophenedicarboxylate355001-63-7C20H22ClNO5S
- Dimethyl 3-methyl-5-[(2-methyl-3-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate543685-32-1C17H16N2O7S
- Propyl 2-[(2-chlorobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylate444936-91-8C17H18ClNO3S
- Ethyl 5-carbamoyl-4-methyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxylate354548-99-5C19H22N2O7S
- 2,4-Bis(1-methylethyl) 3-methyl-5-((2,3,4,5,6-pentafluorobenzoyl)amino)-2,4-thiophenedicarboxylate438614-47-2C20H18F5NO5S
- 4-Cyano-5-[(2,4-dinitrobenzoyl)amino]-N,N,3-trimethylthiophene-2-carboxamide444940-13-0C16H13N5O6S
- Methyl 2-[(4-propoxybenzoyl)amino]-5-propylthiophene-3-carboxylate444940-22-1C19H23NO4S
- 2-O-Methyl 4-O-propan-2-yl 3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2,4-dicarboxylate444998-36-1C18H18N2O7S
- 2-Ethyl 4-propyl 5-({4-nitrobenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate495382-90-6C19H20N2O7S
- Propyl 2-[(5-chloro-2-methoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate444999-92-2C18H20ClNO4S
- Methyl 2-[(3,5-dinitrobenzoyl)amino]-5-methylthiophene-3-carboxylate445000-43-1C14H11N3O7S
- 2-Methyl 4-propyl 3-methyl-5-[(2-methylbenzoyl)amino]thiophene-2,4-dicarboxylate445000-82-8C19H21NO5S
- 2-Methyl 4-propyl 5-({2-nitrobenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate445001-40-1C18H18N2O7S
- 2-Ethyl 4-propyl 5-({2-chloro-5-nitrobenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate495383-48-7C19H19ClN2O7S
- 2-Ethyl 4-propyl 5-({2-chloro-4-nitrobenzoyl}amino)-3-methyl-2,4-thiophenedicarboxylate445002-07-3C19H19ClN2O7S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-5-methyl-, 2-hydroxyethyl ester78033-82-6C15H15NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-hydroxyethyl ester78033-83-7C16H17NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(dimethylamino)ethyl ester78033-84-8C18H22N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(diethylamino)ethyl ester78033-85-9C20H26N2O3S
- 2-Thiopheneacetic acid, 5-benzamido-4-carboxy-3-methyl-105522-85-8C15H13NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals
O=C(Nc1ccccc1)C1CCCC143 chemicals