Murcko scaffold
Benzamide, N-2-thienyl- scaffold
930 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 930
- With full pages
- 52
Scaffold SMILES
O=C(Nc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 241 to 288 of 930 chemicals
![4-Ethyl-5-methyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxamide chemical structure, C18H22N2O5S, CAS 354548-46-2](/s/GUDVXLFOJSOLRX-UHFFFAOYSA-N.svg)
4-Ethyl-5-methyl-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxamide
CAS 354548-46-2C18H22N2O5S
![Methyl 4-cyano-3-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]-2-thiophenecarboxylate chemical structure, C18H18N2O6S, CAS 354550-04-2](/s/SCMMLTOBZPFSRD-UHFFFAOYSA-N.svg)
Methyl 4-cyano-3-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]-2-thiophenecarboxylate
CAS 354550-04-2C18H18N2O6S
![2-[(4-Bromobenzoyl)amino]-4-(2-methylpropyl)thiophene-3-carboxylic acid chemical structure, C16H16BrNO3S, CAS 326878-56-2](/s/BOGMJXQNEBCXOP-UHFFFAOYSA-N.svg)
2-[(4-Bromobenzoyl)amino]-4-(2-methylpropyl)thiophene-3-carboxylic acid
CAS 326878-56-2C16H16BrNO3S
![Ethyl 2-[(4-bromobenzoyl)amino]-5-ethylthiophene-3-carboxylate chemical structure, C16H16BrNO3S, CAS 312939-87-0](/s/OJPCLDUOLKPGGO-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-bromobenzoyl)amino]-5-ethylthiophene-3-carboxylate
CAS 312939-87-0C16H16BrNO3S
![Ethyl 2-[(2-chlorobenzoyl)amino]-4-isobutyl-3-thiophenecarboxylate chemical structure, C18H20ClNO3S, CAS 325822-68-2](/s/XIRFNFDXRJWXGR-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-chlorobenzoyl)amino]-4-isobutyl-3-thiophenecarboxylate
CAS 325822-68-2C18H20ClNO3S
![5-Ethyl-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester chemical structure, C19H23NO6S, CAS 328089-06-1](/s/NJAUWUHPIUZCDO-UHFFFAOYSA-N.svg)
5-Ethyl-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester
CAS 328089-06-1C19H23NO6S
![Dimethyl 3-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]-2,4-thiophenedicarboxylate chemical structure, C19H21NO8S, CAS 379248-30-3](/s/GDGOHHZUYKJYTF-UHFFFAOYSA-N.svg)
Dimethyl 3-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]-2,4-thiophenedicarboxylate
CAS 379248-30-3C19H21NO8S
![Methyl 2-[(2-chloro-4-nitrobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C15H13ClN2O5S, CAS 447449-20-9](/s/XMKNOWGVIZOPFO-UHFFFAOYSA-N.svg)
Methyl 2-[(2-chloro-4-nitrobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 447449-20-9C15H13ClN2O5S
![Ethyl 2-[(2-acetyloxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 461429-42-5](/s/SREYTTFNYVZYQG-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-acetyloxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 461429-42-5C18H19NO5S
![2-[(4-Iodobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid chemical structure, C14H12INO3S, CAS 312940-66-2](/s/PXBKFCQAWKJTTQ-UHFFFAOYSA-N.svg)
2-[(4-Iodobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid
CAS 312940-66-2C14H12INO3S
![Ethyl 2-[(4-tert-butylbenzoyl)amino]-5-ethyl-3-thiophenecarboxylate chemical structure, C20H25NO3S, CAS 461438-30-2](/s/AXBGQUQKHGMGFK-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-tert-butylbenzoyl)amino]-5-ethyl-3-thiophenecarboxylate
CAS 461438-30-2C20H25NO3S
![Ethyl 2-[(3-acetyloxybenzoyl)amino]-5-ethylthiophene-3-carboxylate chemical structure, C18H19NO5S, CAS 380643-81-2](/s/KTXLWXGTMTXDJW-UHFFFAOYSA-N.svg)
Ethyl 2-[(3-acetyloxybenzoyl)amino]-5-ethylthiophene-3-carboxylate
CAS 380643-81-2C18H19NO5S
![Ethyl 2-{[3-(acetyloxy)benzoyl]amino}-4-isobutylthiophene-3-carboxylate chemical structure, C20H23NO5S, CAS 380643-82-3](/s/BVILNECEXLAKNR-UHFFFAOYSA-N.svg)
Ethyl 2-{[3-(acetyloxy)benzoyl]amino}-4-isobutylthiophene-3-carboxylate
CAS 380643-82-3C20H23NO5S
![Ethyl 2-[(3-bromobenzoyl)amino]-5-methylthiophene-3-carboxylate chemical structure, C15H14BrNO3S, CAS 312939-86-9](/s/GPQCNAWLDOGJLV-UHFFFAOYSA-N.svg)
Ethyl 2-[(3-bromobenzoyl)amino]-5-methylthiophene-3-carboxylate
CAS 312939-86-9C15H14BrNO3S
![Ethyl 4-isobutyl-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thiophenecarboxylate chemical structure, C21H27NO6S, CAS 380644-71-3](/s/ONEFWHKOZKDFPV-UHFFFAOYSA-N.svg)
Ethyl 4-isobutyl-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thiophenecarboxylate
CAS 380644-71-3C21H27NO6S
Diethyl 5-(3-iodobenzamido)-3-methylthiophene-2,4-dicarboxylate
CAS 313229-98-0C18H18INO5S
![2-[(3-Bromobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid chemical structure, C14H12BrNO3S, CAS 461438-40-4](/s/CFSZZPWVSFJPDG-UHFFFAOYSA-N.svg)
2-[(3-Bromobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid
CAS 461438-40-4C14H12BrNO3S
Diethyl 3-methyl-5-(4-methylbenzamido)thiophene-2,4-dicarboxylate
CAS 300826-14-6C19H21NO5S
Ethyl 2-(3-acetoxybenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 380643-79-8C18H19NO5S
5-Ethyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylic acid
CAS 342381-71-9C17H19NO6S
![Dimethyl 5-[(2-methoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C17H17NO6S, CAS 424817-98-1](/s/DEEQGSXVFAZZFJ-UHFFFAOYSA-N.svg)
Dimethyl 5-[(2-methoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 424817-98-1C17H17NO6S
![Dimethyl 5-[(3,4-dimethoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate chemical structure, C18H19NO7S, CAS 420091-70-9](/s/YEJHRKKJCOZUIG-UHFFFAOYSA-N.svg)
Dimethyl 5-[(3,4-dimethoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate
CAS 420091-70-9C18H19NO7S
![Ethyl 2-[(2,4-dichlorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H15Cl2NO3S, CAS 314022-16-7](/s/STDLKWPRTZXBPP-UHFFFAOYSA-N.svg)
Ethyl 2-[(2,4-dichlorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 314022-16-7C16H15Cl2NO3S
Diethyl 5-(4-bromobenzamido)-3-methylthiophene-2,4-dicarboxylate
CAS 324065-57-8C18H18BrNO5S
- 2,4-Diethyl 5-(3-methoxybenzamido)-3-methylthiophene-2,4-dicarboxylate307342-19-4C19H21NO6S
- Diethyl 5-(4-fluorobenzamido)-3-methylthiophene-2,4-dicarboxylate307524-38-5C18H18FNO5S
- Ethyl 2-[[4-(dipropylsulfamoyl)benzoyl]amino]-4,5-dimethylthiophene-3-carboxylate331850-87-4C22H30N2O5S2
- Methyl 5-(dipropylcarbamoyl)-2-(4-fluorobenzamido)-4-methylthiophene-3-carboxylate335405-83-9C21H25FN2O4S
- Methyl 2-(4-chlorobenzamido)-5-(dipropylcarbamoyl)-4-methylthiophene-3-carboxylate335407-21-1C21H25ClN2O4S
- Methyl 2-(2,4-dichlorobenzamido)-5-(dipropylcarbamoyl)-4-methylthiophene-3-carboxylate335407-57-3C21H24Cl2N2O4S
- 4-Cyano-N,N-diethyl-3-methyl-5-[(3-nitrobenzoyl)amino]thiophene-2-carboxamide493027-02-4C18H18N4O4S
- Methyl 5-(dipropylcarbamoyl)-4-methyl-2-(2-methylbenzamido)thiophene-3-carboxylate335407-58-4C22H28N2O4S
- Methyl 5-(diethylcarbamoyl)-4-methyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylate505096-31-1C22H28N2O7S
- Methyl 5-(diethylcarbamoyl)-4-methyl-2-[(4-methyl-3-nitrobenzoyl)amino]thiophene-3-carboxylate506416-33-7C20H23N3O6S
- Methyl 5-(dipropylcarbamoyl)-2-(2-fluorobenzamido)-4-methylthiophene-3-carboxylate335410-03-2C21H25FN2O4S
- Methyl 5-(diethylcarbamoyl)-4-methyl-2-[(3-methylbenzoyl)amino]thiophene-3-carboxylate506416-60-0C20H24N2O4S
- Isopropyl 4,5-dimethyl-2-{[3-(trifluoromethyl)benzoyl]amino}-3-thiophenecarboxylate332874-22-3C18H18F3NO3S
- Isopropyl 5-[(diethylamino)carbonyl]-2-[(3-methoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate332874-28-9C22H28N2O5S
- Ethyl 2-[(2-bromo-3,4,5-trimethoxybenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylate302805-63-6C19H22BrNO6S
- Diethyl 5-(2,6-difluorobenzamido)-3-methylthiophene-2,4-dicarboxylate307343-80-2C18H17F2NO5S
- 5-(2-Fluorobenzoylamino)-3-methylthiophene-2,4-dicarboxylic acid, dimethyl ester420094-43-5C16H14FNO5S
- 5-(4-Fluorobenzoylamino)-3-methylthiophene-2,4-dicarboxylic acid, dimethyl ester448915-00-2C16H14FNO5S
- Ethyl 2-[4-(dimethylsulfamoyl)benzamido]-4,5-dimethylthiophene-3-carboxylate314275-36-0C18H22N2O5S2
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-5-methyl-, 2-hydroxyethyl ester78033-82-6C15H15NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-hydroxyethyl ester78033-83-7C16H17NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(dimethylamino)ethyl ester78033-84-8C18H22N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(diethylamino)ethyl ester78033-85-9C20H26N2O3S
- 2-Thiopheneacetic acid, 5-benzamido-4-carboxy-3-methyl-105522-85-8C15H13NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals
O=C(Nc1ccccc1)C1CCCC143 chemicals