Murcko scaffold
Benzamide, N-2-thienyl- scaffold
930 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 930
- With full pages
- 52
Scaffold SMILES
O=C(Nc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 337 to 384 of 930 chemicals
Diethyl 5-(2,3-dimethoxybenzamido)-3-methylthiophene-2,4-dicarboxylate
CAS 775301-42-3C20H23NO7S
![2-[(3,4,5-Triethoxybenzoyl)amino]thiophene-3-carboxamide chemical structure, C18H22N2O5S, CAS 717868-65-0](/s/UOWPDDZBEUNCDS-UHFFFAOYSA-N.svg)
2-[(3,4,5-Triethoxybenzoyl)amino]thiophene-3-carboxamide
CAS 717868-65-0C18H22N2O5S
5-Bromo-2-chloro-N-(3-cyano-4,5-dimethylthiophen-2-yl)benzamide
CAS 717870-32-1C14H10BrClN2OS
![4-Ethyl-5-methyl-2-[(4-propan-2-yloxybenzoyl)amino]thiophene-3-carboxamide chemical structure, C18H22N2O3S, CAS 717872-53-2](/s/CIEIUJUQURGTNJ-UHFFFAOYSA-N.svg)
4-Ethyl-5-methyl-2-[(4-propan-2-yloxybenzoyl)amino]thiophene-3-carboxamide
CAS 717872-53-2C18H22N2O3S
![2-[(3,5-Dichlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H14Cl2N2O2S, CAS 774575-16-5](/s/RYMHAJYBDMQKOE-UHFFFAOYSA-N.svg)
2-[(3,5-Dichlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 774575-16-5C15H14Cl2N2O2S
![Diethyl 3-methyl-5-[(2,3,5,6-tetrafluoro-4-methoxybenzoyl)amino]-2,4-thiophenedicarboxylate chemical structure, C19H17F4NO6S, CAS 832107-32-1](/s/KKTVUGLOSIUWHL-UHFFFAOYSA-N.svg)
Diethyl 3-methyl-5-[(2,3,5,6-tetrafluoro-4-methoxybenzoyl)amino]-2,4-thiophenedicarboxylate
CAS 832107-32-1C19H17F4NO6S
![Ethyl 4,5-dimethyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C17H18N2O5S, CAS 418780-04-8](/s/SCOFWWJZGWZWCF-UHFFFAOYSA-N.svg)
Ethyl 4,5-dimethyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 418780-04-8C17H18N2O5S
![Ethyl 5-acetyl-4-methyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C18H18N2O6S, CAS 445464-96-0](/s/GOTGQDMTPRYMTQ-UHFFFAOYSA-N.svg)
Ethyl 5-acetyl-4-methyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 445464-96-0C18H18N2O6S
![4-Ethyl 2-methyl 5-{[(2-fluorophenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate chemical structure, C17H16FNO5S, CAS 443122-93-8](/s/PPOXLYOIJCQKRS-UHFFFAOYSA-N.svg)
4-Ethyl 2-methyl 5-{[(2-fluorophenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate
CAS 443122-93-8C17H16FNO5S
![Methyl 2-[(3,4-dimethoxybenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C18H21NO5S, CAS 330657-85-7](/s/PLPGQKXITXYYDN-UHFFFAOYSA-N.svg)
Methyl 2-[(3,4-dimethoxybenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate
CAS 330657-85-7C18H21NO5S
Diethyl 5-(4-isopropoxybenzamido)-3-methylthiophene-2,4-dicarboxylate
CAS 462615-33-4C21H25NO6S
Diethyl 5-(2,4-dimethylbenzamido)-3-methylthiophene-2,4-dicarboxylate
CAS 674361-57-0C20H23NO5S
![Propan-2-yl 4-ethyl-5-methyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C19H22N2O5S, CAS 438463-85-5](/s/UMWFFUVYYBTKEY-UHFFFAOYSA-N.svg)
Propan-2-yl 4-ethyl-5-methyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 438463-85-5C19H22N2O5S
Isopropyl 2-({2-chloro-5-nitrobenzoyl}amino)-4,5-dimethyl-3-thiophenecarboxylate
CAS 445229-50-5C17H17ClN2O5S
![Methyl 2-[(4-chloro-3-nitrobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate chemical structure, C16H15ClN2O5S, CAS 544451-15-2](/s/QTGOHCJIVUKEAQ-UHFFFAOYSA-N.svg)
Methyl 2-[(4-chloro-3-nitrobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate
CAS 544451-15-2C16H15ClN2O5S
![Ethyl 2-[(4-chloro-2-nitrobenzoyl)amino]-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C18H18ClN3O6S, CAS 547703-77-5](/s/IQQVLYTVNDSMRH-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-chloro-2-nitrobenzoyl)amino]-5-(dimethylcarbamoyl)-4-methylthiophene-3-carboxylate
CAS 547703-77-5C18H18ClN3O6S
![Propan-2-yl 4,5-dimethyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C17H18N2O5S, CAS 541544-29-0](/s/WSZCHYIPIMOYQW-UHFFFAOYSA-N.svg)
Propan-2-yl 4,5-dimethyl-2-[(4-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 541544-29-0C17H18N2O5S
![2-[(4-Chloro-2-nitrobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide chemical structure, C15H14ClN3O4S, CAS 544680-09-3](/s/ACQPZBSJACCKGO-UHFFFAOYSA-N.svg)
2-[(4-Chloro-2-nitrobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide
CAS 544680-09-3C15H14ClN3O4S
Dimethyl 5-(4-methoxybenzamido)-3-methylthiophene-2,4-dicarboxylate
CAS 503432-82-4C17H17NO6S
![2-[(2-Chloro-5-nitrobenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C14H12ClN3O4S, CAS 550306-75-7](/s/BDLMZMPXYVTPTQ-UHFFFAOYSA-N.svg)
2-[(2-Chloro-5-nitrobenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide
CAS 550306-75-7C14H12ClN3O4S
![Ethyl 2-{[(3,5-dichloro-4-methoxyphenyl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate chemical structure, C17H17Cl2NO4S, CAS 824422-73-3](/s/MSSBIKLQMJRUBT-UHFFFAOYSA-N.svg)
Ethyl 2-{[(3,5-dichloro-4-methoxyphenyl)carbonyl]amino}-4,5-dimethylthiophene-3-carboxylate
CAS 824422-73-3C17H17Cl2NO4S
![Methyl 5-acetyl-2-[(3,5-dichloro-4-ethoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate chemical structure, C18H17Cl2NO5S, CAS 692279-99-5](/s/AKPJASJZLPYNQP-UHFFFAOYSA-N.svg)
Methyl 5-acetyl-2-[(3,5-dichloro-4-ethoxybenzoyl)amino]-4-methyl-3-thiophenecarboxylate
CAS 692279-99-5C18H17Cl2NO5S
Ethyl 5-acetyl-2-(4-ethoxybenzamido)-4-methylthiophene-3-carboxylate
CAS 544655-46-1C19H21NO5S
![Ethyl 2-[(4-iodobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H16INO3S, CAS 312939-99-4](/s/OUKNVRCYHSKFSN-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-iodobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 312939-99-4C16H16INO3S
- 4-Ethyl 2-methyl 5-{[(3-chloro-4-ethoxyphenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate433705-63-6C19H20ClNO6S
- 4-Ethyl 2-methyl 5-{[(3-chloro-4-methylphenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate433707-69-8C18H18ClNO5S
- Methyl 5-(4-(tert-butyl)benzamido)-4-cyano-3-methylthiophene-2-carboxylate462613-27-0C19H20N2O3S
- Diethyl 5-[(5-chloro-2-methoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate351061-65-9C19H20ClNO6S
- Diethyl 3-methyl-5-({[4-(propan-2-yl)phenyl]carbonyl}amino)thiophene-2,4-dicarboxylate461411-55-2C21H25NO5S
- Diethyl 5-{[(4-ethoxyphenyl)carbonyl]amino}-3-methylthiophene-2,4-dicarboxylate431933-07-2C20H23NO6S
- 2-[[3-Ethoxycarbonyl-4-(2-methylpropyl)thiophen-2-yl]carbamoyl]benzoic acid325739-96-6C19H21NO5S
- Ethyl 2-[(2-iodobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate312528-77-1C16H16INO3S
- Ethyl 5-ethyl-2-(2-iodobenzamido)thiophene-3-carboxylate312528-78-2C16H16INO3S
- Ethyl 4-carbamoyl-5-[(3,5-dimethoxybenzoyl)amino]-3-methylthiophene-2-carboxylate5691-69-0C18H20N2O6S
- Propan-2-yl 5-[(3-chlorobenzoyl)amino]-4-cyano-3-methylthiophene-2-carboxylate5692-21-7C17H15ClN2O3S
- Ethyl 5-acetyl-2-[(3,4-dimethylbenzoyl)amino]-4-methylthiophene-3-carboxylate419558-43-3C19H21NO4S
- 5-{[(4-Chlorophenyl)carbonyl]amino}-4-cyano-N,N-diethyl-3-methylthiophene-2-carboxamide5693-10-7C18H18ClN3O2S
- Propan-2-yl 2-[(3-bromobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate419558-98-8C17H18BrNO3S
- N-(3-Cyano-4-ethyl-5-methylthiophen-2-yl)-3,4,5-trimethoxybenzamide352679-01-7C18H20N2O4S
- Propan-2-yl 2-[(2-chloro-4-nitrobenzoyl)amino]-5-(diethylcarbamoyl)-4-methylthiophene-3-carboxylate419559-47-0C21H24ClN3O6S
- Dipropan-2-yl 5-[(4-methoxybenzoyl)amino]-3-methylthiophene-2,4-dicarboxylate419559-83-4C21H25NO6S
- Ethyl 2-(5-chloro-2-nitrobenzamido)-4,5-dimethylthiophene-3-carboxylate419559-94-7C16H15ClN2O5S
- Methyl 5-(diethylcarbamoyl)-2-{[(4-ethoxyphenyl)carbonyl]amino}-4-methylthiophene-3-carboxylate420089-60-7C21H26N2O5S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-5-methyl-, 2-hydroxyethyl ester78033-82-6C15H15NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-hydroxyethyl ester78033-83-7C16H17NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(dimethylamino)ethyl ester78033-84-8C18H22N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(diethylamino)ethyl ester78033-85-9C20H26N2O3S
- 2-Thiopheneacetic acid, 5-benzamido-4-carboxy-3-methyl-105522-85-8C15H13NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals
O=C(Nc1ccccc1)C1CCCC143 chemicals