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Murcko scaffold

Ring system with 3 rings and 20 atoms

21 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
21
With full pages
7
Scaffold SMILES

O=C1NC(=Nc2ccccc2)SC1=Cc1cccnc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=Nc2ccccc2)SC1=Cc1cccnc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

3-[[(5Z)-3-Methyl-4-oxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-2-ylidene]amino]benzoic acid chemical structure, C17H13N3O3S, CAS 591764-01-1
3-[[(5Z)-3-Methyl-4-oxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-2-ylidene]amino]benzoic acid
CAS 591764-01-1C17H13N3O3S
(5Z)-2-(4-Fluoroanilino)-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4-one chemical structure, C15H10FN3OS, CAS 333409-56-6
(5Z)-2-(4-Fluoroanilino)-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4-one
CAS 333409-56-6C15H10FN3OS
(2E,5Z)-2-[(3,5-Dichlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C15H9Cl2N3OS, CAS 496798-80-2
(2E,5Z)-2-[(3,5-Dichlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 496798-80-2C15H9Cl2N3OS
(2E,5Z)-2-[(4-Chlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C15H10ClN3OS, CAS 488860-55-5
(2E,5Z)-2-[(4-Chlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 488860-55-5C15H10ClN3OS
(2E,5Z)-2-[(2-Bromophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C15H10BrN3OS, CAS 674818-05-4
(2E,5Z)-2-[(2-Bromophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 674818-05-4C15H10BrN3OS
(5Z)-2-{[4-Chloro-2-(trifluoromethyl)phenyl]amino}-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C16H9ClF3N3OS, CAS 849032-08-2
(5Z)-2-{[4-Chloro-2-(trifluoromethyl)phenyl]amino}-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4(5H)-one
CAS 849032-08-2C16H9ClF3N3OS
(2Z,5Z)-2-[(4-Bromophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C15H10BrN3OS, CAS 641997-61-7
(2Z,5Z)-2-[(4-Bromophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 641997-61-7C15H10BrN3OS
(2E,5Z)-2-[(2,4-Dichlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C15H9Cl2N3OS, CAS 498536-35-9
(2E,5Z)-2-[(2,4-Dichlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 498536-35-9C15H9Cl2N3OS
(2Z,5Z)-2-((4-Hydroxyphenyl)imino)-5-(pyridin-3-ylmethylene)thiazolidin-4-one chemical structure, C15H11N3O2S, CAS 1351357-92-0
(2Z,5Z)-2-((4-Hydroxyphenyl)imino)-5-(pyridin-3-ylmethylene)thiazolidin-4-one
CAS 1351357-92-0C15H11N3O2S
(2E,5Z)-5-(Pyridin-3-ylmethylidene)-2-{[2-(trifluoromethyl)phenyl]imino}-1,3-thiazolidin-4-one chemical structure, C16H10F3N3OS, CAS 488744-35-0
(2E,5Z)-5-(Pyridin-3-ylmethylidene)-2-{[2-(trifluoromethyl)phenyl]imino}-1,3-thiazolidin-4-one
CAS 488744-35-0C16H10F3N3OS
(5Z)-2-Anilino-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4-one chemical structure, C15H11N3OS, CAS 331653-96-4
(5Z)-2-Anilino-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4-one
CAS 331653-96-4C15H11N3OS
5-(Pyridin-3-ylmethylene)-2-(3-(trifluoromethyl)phenylamino)thiazol-4(5H)-one chemical structure, C16H10F3N3OS, CAS 488795-70-6
5-(Pyridin-3-ylmethylene)-2-(3-(trifluoromethyl)phenylamino)thiazol-4(5H)-one
CAS 488795-70-6C16H10F3N3OS
5-[(Pyridin-3-yl)methylidene]-2-{[3-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1,3-thiazol-4-one chemical structure, C16H10F3N3OS
5-[(Pyridin-3-yl)methylidene]-2-{[3-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1,3-thiazol-4-one
C16H10F3N3OS
(2Z,5Z)-2-[(2,3-Dichlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C15H9Cl2N3OS, CAS 363577-00-8
(2Z,5Z)-2-[(2,3-Dichlorophenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 363577-00-8C15H9Cl2N3OS
(5Z)-2-[(2,4-Dimethylphenyl)amino]-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C17H15N3OS, CAS 641996-67-0
(5Z)-2-[(2,4-Dimethylphenyl)amino]-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4(5H)-one
CAS 641996-67-0C17H15N3OS
(2Z,5Z)-2-[(3-Methylphenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C16H13N3OS, CAS 641997-55-9
(2Z,5Z)-2-[(3-Methylphenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 641997-55-9C16H13N3OS
(2Z,5Z)-2-((2,3-Dimethylphenyl)imino)-5-(pyridin-3-ylmethylene)thiazolidin-4-one chemical structure, C17H15N3OS, CAS 641996-75-0
(2Z,5Z)-2-((2,3-Dimethylphenyl)imino)-5-(pyridin-3-ylmethylene)thiazolidin-4-one
CAS 641996-75-0C17H15N3OS
(2Z,5Z)-5-(Pyridin-3-ylmethylene)-2-(p-tolylimino)thiazolidin-4-one chemical structure, C16H13N3OS, CAS 463317-02-4
(2Z,5Z)-5-(Pyridin-3-ylmethylene)-2-(p-tolylimino)thiazolidin-4-one
CAS 463317-02-4C16H13N3OS
(5Z)-2-[(2-Methylphenyl)amino]-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4(5H)-one chemical structure, C16H13N3OS, CAS 641997-51-5
(5Z)-2-[(2-Methylphenyl)amino]-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4(5H)-one
CAS 641997-51-5C16H13N3OS
(2E,5Z)-2-[(3,4-Dimethylphenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one chemical structure, C17H15N3OS, CAS 359646-12-1
(2E,5Z)-2-[(3,4-Dimethylphenyl)imino]-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-4-one
CAS 359646-12-1C17H15N3OS
(5Z)-2-(3-Hydroxyanilino)-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4-one chemical structure, C15H11N3O2S, CAS 641996-83-0
(5Z)-2-(3-Hydroxyanilino)-5-(pyridin-3-ylmethylidene)-1,3-thiazol-4-one
CAS 641996-83-0C15H11N3O2S