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Murcko scaffold

Ring system with 3 rings and 20 atoms

374 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
374
With full pages
17
Scaffold SMILES

O=C1NC(=Nc2ccccc2)SC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=Nc2ccccc2)SC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 374 chemicals

4-[[(5Z)-5-[(4-Methoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-3-methyl-4-oxo-1,3-thiazolidin-2-ylidene]amino]benzoic acid chemical structure, C23H24N2O4S, CAS 443875-21-6
4-[[(5Z)-5-[(4-Methoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-3-methyl-4-oxo-1,3-thiazolidin-2-ylidene]amino]benzoic acid
CAS 443875-21-6C23H24N2O4S
3-{[5-(4-Methoxy-3-methylbenzylidene)-3-methyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoic acid chemical structure, C20H18N2O4S, CAS 443872-80-8
3-{[5-(4-Methoxy-3-methylbenzylidene)-3-methyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoic acid
CAS 443872-80-8C20H18N2O4S
Methyl 4-{[5-(2-ethoxybenzylidene)-3-methyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoate chemical structure, C21H20N2O4S, CAS 443874-82-6
Methyl 4-{[5-(2-ethoxybenzylidene)-3-methyl-4-oxo-1,3-thiazolidin-2-ylidene]amino}benzoate
CAS 443874-82-6C21H20N2O4S
5-(3-Ethoxy-4-hydroxybenzylidene)-3-isobutyl-2-[(4-methoxyphenyl)imino]-1,3-thiazolidin-4-one chemical structure, C23H26N2O4S, CAS 443871-51-0
5-(3-Ethoxy-4-hydroxybenzylidene)-3-isobutyl-2-[(4-methoxyphenyl)imino]-1,3-thiazolidin-4-one
CAS 443871-51-0C23H26N2O4S
(2E,5Z)-3-Allyl-5-(4-(dimethylamino)benzylidene)-2-(phenylimino)thiazolidin-4-one chemical structure, C21H21N3OS, CAS 359817-16-6
(2E,5Z)-3-Allyl-5-(4-(dimethylamino)benzylidene)-2-(phenylimino)thiazolidin-4-one
CAS 359817-16-6C21H21N3OS
4-((E)-((Z)-3-Allyl-5-(3,4-dimethoxybenzylidene)-4-oxothiazolidin-2-ylidene)amino)benzoic acid chemical structure, C22H20N2O5S, CAS 638136-66-0
4-((E)-((Z)-3-Allyl-5-(3,4-dimethoxybenzylidene)-4-oxothiazolidin-2-ylidene)amino)benzoic acid
CAS 638136-66-0C22H20N2O5S
(5Z)-5-(4-Fluorobenzylidene)-2-[(4-hydroxyphenyl)(methyl)amino]-1,3-thiazol-4(5H)-one chemical structure, C17H13FN2O2S, CAS 307544-59-8
(5Z)-5-(4-Fluorobenzylidene)-2-[(4-hydroxyphenyl)(methyl)amino]-1,3-thiazol-4(5H)-one
CAS 307544-59-8C17H13FN2O2S
(5E)-5-[(4-Fluorophenyl)methylidene]-2-(4-hydroxy-N-methylanilino)-1,3-thiazol-4-one chemical structure, C17H13FN2O2S, CAS 6151-85-5
(5E)-5-[(4-Fluorophenyl)methylidene]-2-(4-hydroxy-N-methylanilino)-1,3-thiazol-4-one
CAS 6151-85-5C17H13FN2O2S
(5Z)-5-(4-Chlorobenzylidene)-2-[(4-hydroxyphenyl)(methyl)amino]-1,3-thiazol-4(5H)-one chemical structure, C17H13ClN2O2S, CAS 307544-60-1
(5Z)-5-(4-Chlorobenzylidene)-2-[(4-hydroxyphenyl)(methyl)amino]-1,3-thiazol-4(5H)-one
CAS 307544-60-1C17H13ClN2O2S
(5Z)-2-(4-Hydroxy-N-methylanilino)-5-[(4-nitrophenyl)methylidene]-1,3-thiazol-4-one chemical structure, C17H13N3O4S, CAS 308298-11-5
(5Z)-2-(4-Hydroxy-N-methylanilino)-5-[(4-nitrophenyl)methylidene]-1,3-thiazol-4-one
CAS 308298-11-5C17H13N3O4S
(5E)-5-(2-Chlorobenzylidene)-2-[(4-hydroxyphenyl)(methyl)amino]-1,3-thiazol-4(5H)-one chemical structure, C17H13ClN2O2S, CAS 405919-87-1
(5E)-5-(2-Chlorobenzylidene)-2-[(4-hydroxyphenyl)(methyl)amino]-1,3-thiazol-4(5H)-one
CAS 405919-87-1C17H13ClN2O2S
5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-2-[(4-chlorophenyl)imino]-3-methyl-1,3-thiazolidin-4-one chemical structure, C18H14BrClN2O3S, CAS 486442-41-5
5-(3-Bromo-4-hydroxy-5-methoxybenzylidene)-2-[(4-chlorophenyl)imino]-3-methyl-1,3-thiazolidin-4-one
CAS 486442-41-5C18H14BrClN2O3S
2-[(4-Chlorophenyl)imino]-5-(2,3-dimethoxybenzylidene)-3-methyl-1,3-thiazolidin-4-one chemical structure, C19H17ClN2O3S, CAS 486442-52-8
2-[(4-Chlorophenyl)imino]-5-(2,3-dimethoxybenzylidene)-3-methyl-1,3-thiazolidin-4-one
CAS 486442-52-8C19H17ClN2O3S
5-Benzylidene-2-[(2,6-dimethylphenyl)imino]-3-methyl-1,3-thiazolidin-4-one chemical structure, C19H18N2OS, CAS 491583-12-1
5-Benzylidene-2-[(2,6-dimethylphenyl)imino]-3-methyl-1,3-thiazolidin-4-one
CAS 491583-12-1C19H18N2OS
(2Z,5Z)-3-(2-Methoxyethyl)-2-(phenylimino)-5-[2-(propan-2-yloxy)benzylidene]-1,3-thiazolidin-4-one chemical structure, C22H24N2O3S, CAS 496767-79-4
(2Z,5Z)-3-(2-Methoxyethyl)-2-(phenylimino)-5-[2-(propan-2-yloxy)benzylidene]-1,3-thiazolidin-4-one
CAS 496767-79-4C22H24N2O3S
5-(3,4-Dimethoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one chemical structure, C23H26N2O4S, CAS 443873-17-4
5-(3,4-Dimethoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one
CAS 443873-17-4C23H26N2O4S
5-(3-Chloro-4-hydroxy-5-methoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one chemical structure, C22H23ClN2O4S, CAS 443877-82-5
5-(3-Chloro-4-hydroxy-5-methoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one
CAS 443877-82-5C22H23ClN2O4S
5-(3-Ethoxy-2-hydroxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one chemical structure, C23H26N2O4S, CAS 443871-71-4
5-(3-Ethoxy-2-hydroxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one
CAS 443871-71-4C23H26N2O4S
5-(3-Chloro-4-methoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one chemical structure, C22H23ClN2O3S, CAS 443873-16-3
5-(3-Chloro-4-methoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-propyl-1,3-thiazolidin-4-one
CAS 443873-16-3C22H23ClN2O3S
5-(2,4-Dimethoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-ethyl-1,3-thiazolidin-4-one chemical structure, C22H24N2O4S, CAS 443877-36-9
5-(2,4-Dimethoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-ethyl-1,3-thiazolidin-4-one
CAS 443877-36-9C22H24N2O4S
5-(3-Bromo-4-methoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-ethyl-1,3-thiazolidin-4-one chemical structure, C21H21BrN2O3S, CAS 443874-14-4
5-(3-Bromo-4-methoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-ethyl-1,3-thiazolidin-4-one
CAS 443874-14-4C21H21BrN2O3S
2-[(4-Ethoxyphenyl)imino]-3-ethyl-5-(4-hydroxy-3-iodobenzylidene)-1,3-thiazolidin-4-one chemical structure, C20H19IN2O3S, CAS 443871-87-2
2-[(4-Ethoxyphenyl)imino]-3-ethyl-5-(4-hydroxy-3-iodobenzylidene)-1,3-thiazolidin-4-one
CAS 443871-87-2C20H19IN2O3S
Methyl 4-({2-[(4-ethoxyphenyl)imino]-3-ethyl-4-oxo-1,3-thiazolidin-5-ylidene}methyl)benzoate chemical structure, C22H22N2O4S, CAS 443875-76-1
Methyl 4-({2-[(4-ethoxyphenyl)imino]-3-ethyl-4-oxo-1,3-thiazolidin-5-ylidene}methyl)benzoate
CAS 443875-76-1C22H22N2O4S
5-(2,4-Diethoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-ethyl-1,3-thiazolidin-4-one chemical structure, C24H28N2O4S, CAS 443873-39-0
5-(2,4-Diethoxybenzylidene)-2-[(4-ethoxyphenyl)imino]-3-ethyl-1,3-thiazolidin-4-one
CAS 443873-39-0C24H28N2O4S