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Murcko scaffold

Ring system with 3 rings and 21 atoms

56 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
56
With full pages
11
Scaffold SMILES

O=C1C(=Cc2ccccc2)SC(=S)N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=Cc2ccccc2)SC(=S)N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 56 chemicals

3-Benzyl-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H17NO3S2, CAS 324565-14-2
3-Benzyl-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 324565-14-2C19H17NO3S2
3-Benzyl-5-(2-hydroxy-5-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H15NO3S2, CAS 292077-19-1
3-Benzyl-5-(2-hydroxy-5-methoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 292077-19-1C18H15NO3S2
(5Z)-3-Benzyl-5-[(5-bromo-3-ethoxy-2-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H16BrNO3S2, CAS 292077-14-6
(5Z)-3-Benzyl-5-[(5-bromo-3-ethoxy-2-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 292077-14-6C19H16BrNO3S2
3-Benzyl-5-(4-methylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H15NOS2, CAS 324565-28-8
3-Benzyl-5-(4-methylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 324565-28-8C18H15NOS2
(5E)-3-Benzyl-5-[(4-methoxy-3-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C18H14N2O4S2, CAS 329078-85-5
(5E)-3-Benzyl-5-[(4-methoxy-3-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 329078-85-5C18H14N2O4S2
(5Z)-3-Benzyl-5-[1-(3,4-dimethylphenyl)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H19NOS2, CAS 612803-40-4
(5Z)-3-Benzyl-5-[1-(3,4-dimethylphenyl)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 612803-40-4C20H19NOS2
(5Z)-3-Benzyl-5-[1-(3,4-dimethoxyphenyl)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 612803-41-5
(5Z)-3-Benzyl-5-[1-(3,4-dimethoxyphenyl)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 612803-41-5C20H19NO3S2
(5Z)-3-Benzyl-5-[1-(4-hydroxyphenyl)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C18H15NO2S2, CAS 612803-39-1
(5Z)-3-Benzyl-5-[1-(4-hydroxyphenyl)ethylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 612803-39-1C18H15NO2S2
4-[(E)-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl acetate chemical structure, C19H15NO3S2, CAS 6223-53-6
4-[(E)-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl acetate
CAS 6223-53-6C19H15NO3S2
(5Z)-3-(4-Chlorobenzyl)-2-thioxo-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidin-4-one chemical structure, C20H18ClNO4S2, CAS 404838-30-8
(5Z)-3-(4-Chlorobenzyl)-2-thioxo-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazolidin-4-one
CAS 404838-30-8C20H18ClNO4S2
(5E)-3-Benzyl-5-(2-hydroxy-5-methylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C18H15NO2S2, CAS 429653-93-0
(5E)-3-Benzyl-5-(2-hydroxy-5-methylbenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 429653-93-0C18H15NO2S2
(Z)-3-Benzyl-5-(2-methoxybenzylidene)-2-thioxothiazolidin-4-one chemical structure, C18H15NO2S2, CAS 292077-08-8
(Z)-3-Benzyl-5-(2-methoxybenzylidene)-2-thioxothiazolidin-4-one
CAS 292077-08-8C18H15NO2S2
(5Z)-3-Benzyl-5-(2,3-dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C19H17NO3S2, CAS 330178-53-5
(5Z)-3-Benzyl-5-(2,3-dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 330178-53-5C19H17NO3S2
(5Z)-3-Benzyl-5-(2,4-diethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H21NO3S2, CAS 359624-77-4
(5Z)-3-Benzyl-5-(2,4-diethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 359624-77-4C21H21NO3S2
(Z)-3-Benzyl-5-(4-ethoxy-3-methoxybenzylidene)-2-thioxothiazolidin-4-one chemical structure, C20H19NO3S2, CAS 612802-93-4
(Z)-3-Benzyl-5-(4-ethoxy-3-methoxybenzylidene)-2-thioxothiazolidin-4-one
CAS 612802-93-4C20H19NO3S2
(5E)-3-Benzyl-5-{[4-(diethylamino)phenyl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H22N2OS2, CAS 292077-10-2
(5E)-3-Benzyl-5-{[4-(diethylamino)phenyl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 292077-10-2C21H22N2OS2
(5Z)-3-Benzyl-5-[4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H17NO2S2, CAS 431884-76-3
(5Z)-3-Benzyl-5-[4-(prop-2-en-1-yloxy)benzylidene]-2-thioxo-1,3-thiazolidin-4-one
CAS 431884-76-3C20H17NO2S2
Rhodanine, 3-benzyl-5-benzylidene- chemical structure, C17H13NOS2, CAS 23509-48-0
Rhodanine, 3-benzyl-5-benzylidene-
CAS 23509-48-0C17H13NOS2
(5Z)-3-Benzyl-5-[(4-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H12N2O3S2, CAS 298190-64-4
(5Z)-3-Benzyl-5-[(4-nitrophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 298190-64-4C17H12N2O3S2
Rhodanine, 3-benzyl-5-(p-chlorobenzylidene)- chemical structure, C17H12ClNOS2, CAS 23509-49-1
Rhodanine, 3-benzyl-5-(p-chlorobenzylidene)-
CAS 23509-49-1C17H12ClNOS2
(5E)-3-Benzyl-5-[(3,5-dichloro-4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H11Cl2NO2S2, CAS 299906-20-0
(5E)-3-Benzyl-5-[(3,5-dichloro-4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299906-20-0C17H11Cl2NO2S2
3-Benzyl-5-(4-hydroxy-3-methoxy-benzylidene)-2-thioxo-thiazolidin-4-one chemical structure, C18H15NO3S2, CAS 299964-52-6
3-Benzyl-5-(4-hydroxy-3-methoxy-benzylidene)-2-thioxo-thiazolidin-4-one
CAS 299964-52-6C18H15NO3S2
4-[(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehyde chemical structure, C18H13NO2S2, CAS 344897-92-3
4-[(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]benzaldehyde
CAS 344897-92-3C18H13NO2S2
3-Benzyl-2-thioxo-5-[4-(trifluoromethyl)benzylidene]-1,3-thiazolidin-4-one chemical structure, C18H12F3NOS2, CAS 330178-56-8
3-Benzyl-2-thioxo-5-[4-(trifluoromethyl)benzylidene]-1,3-thiazolidin-4-one
CAS 330178-56-8C18H12F3NOS2