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Murcko scaffold

Ring system with 3 rings and 21 atoms

113 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
113
With full pages
11
Scaffold SMILES

O=C1SC(=Cc2ccccc2)C(=O)N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1SC(=Cc2ccccc2)C(=O)N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 113 chemicals

(5Z)-3-Benzyl-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione chemical structure, C19H18N2O2S, CAS 50616-71-2
(5Z)-3-Benzyl-5-[4-(dimethylamino)benzylidene]-1,3-thiazolidine-2,4-dione
CAS 50616-71-2C19H18N2O2S
2-[2,6-Dichloro-4-[[3-[(2-cyanophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]acetic acid chemical structure, C20H12Cl2N2O5S, CAS 6447-28-5
2-[2,6-Dichloro-4-[[3-[(2-cyanophenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]phenoxy]acetic acid
CAS 6447-28-5C20H12Cl2N2O5S
5-(2,4-Dimethoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione chemical structure, C19H16FNO4S, CAS 428834-76-8
5-(2,4-Dimethoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
CAS 428834-76-8C19H16FNO4S
3-[(4-Fluorophenyl)methyl]-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione chemical structure, C17H11F2NO2S, CAS 137660-69-6
3-[(4-Fluorophenyl)methyl]-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS 137660-69-6C17H11F2NO2S
5-[4-(Diethylamino)benzylidene]-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione chemical structure, C21H21FN2O2S, CAS 428828-22-2
5-[4-(Diethylamino)benzylidene]-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
CAS 428828-22-2C21H21FN2O2S
(5Z)-3-[(4-Bromophenyl)methyl]-5-[(3-hydroxy-4-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione chemical structure, C18H14BrNO4S, CAS 428846-99-5
(5Z)-3-[(4-Bromophenyl)methyl]-5-[(3-hydroxy-4-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS 428846-99-5C18H14BrNO4S
(5Z)-3-[(4-Bromophenyl)methyl]-5-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione chemical structure, C19H15BrN2O6S, CAS 428830-93-7
(5Z)-3-[(4-Bromophenyl)methyl]-5-[(4,5-dimethoxy-2-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS 428830-93-7C19H15BrN2O6S
Methyl 4-{[3-(4-bromobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate chemical structure, C19H14BrNO4S, CAS 428847-45-4
Methyl 4-{[3-(4-bromobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate
CAS 428847-45-4C19H14BrNO4S
(5Z)-3-[(4-Bromophenyl)methyl]-5-[(2-chloro-4,5-dimethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione chemical structure, C19H15BrClNO4S, CAS 428849-36-9
(5Z)-3-[(4-Bromophenyl)methyl]-5-[(2-chloro-4,5-dimethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS 428849-36-9C19H15BrClNO4S
3-(4-Fluorobenzyl)-5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-1,3-thiazolidine-2,4-dione chemical structure, C18H13FN2O6S, CAS 429622-05-9
3-(4-Fluorobenzyl)-5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-1,3-thiazolidine-2,4-dione
CAS 429622-05-9C18H13FN2O6S
(5Z)-5-[(2-Bromo-5-ethoxy-4-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C20H17BrFNO4S, CAS 428503-76-8
(5Z)-5-[(2-Bromo-5-ethoxy-4-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 428503-76-8C20H17BrFNO4S
5-(3-Bromo-4,5-dimethoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione chemical structure, C19H15BrFNO4S, CAS 428835-83-0
5-(3-Bromo-4,5-dimethoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
CAS 428835-83-0C19H15BrFNO4S
5-(2-Chloro-4,5-dimethoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione chemical structure, C19H15ClFNO4S, CAS 428835-72-7
5-(2-Chloro-4,5-dimethoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
CAS 428835-72-7C19H15ClFNO4S
5-(3,5-Dichloro-2-methoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione chemical structure, C18H12Cl2FNO3S, CAS 428829-69-0
5-(3,5-Dichloro-2-methoxybenzylidene)-3-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione
CAS 428829-69-0C18H12Cl2FNO3S
(5Z)-5-[(2,4-Diethoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C21H20FNO4S, CAS 428830-72-2
(5Z)-5-[(2,4-Diethoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 428830-72-2C21H20FNO4S
(5Z)-5-[(3-Chloro-4-hydroxy-5-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C18H13ClFNO4S, CAS 429623-18-7
(5Z)-5-[(3-Chloro-4-hydroxy-5-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 429623-18-7C18H13ClFNO4S
(5Z)-5-[(3-Ethoxy-2-hydroxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C19H16FNO4S, CAS 428850-39-9
(5Z)-5-[(3-Ethoxy-2-hydroxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 428850-39-9C19H16FNO4S
(5Z)-3-[(4-Fluorophenyl)methyl]-5-[(4-methoxy-3-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione chemical structure, C19H16FNO3S, CAS 428844-31-9
(5Z)-3-[(4-Fluorophenyl)methyl]-5-[(4-methoxy-3-methylphenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS 428844-31-9C19H16FNO3S
(5Z)-5-[(5-Bromo-2-ethoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C19H15BrFNO3S, CAS 428853-90-1
(5Z)-5-[(5-Bromo-2-ethoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 428853-90-1C19H15BrFNO3S
(5Z)-5-[(3-Chloro-4-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C18H13ClFNO3S, CAS 364737-29-1
(5Z)-5-[(3-Chloro-4-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 364737-29-1C18H13ClFNO3S
(5Z)-5-[(5-Bromo-2-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C18H13BrFNO3S, CAS 428834-30-4
(5Z)-5-[(5-Bromo-2-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 428834-30-4C18H13BrFNO3S
Methyl 4-{[3-(4-chlorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate chemical structure, C19H14ClNO4S, CAS 428842-46-0
Methyl 4-{[3-(4-chlorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}benzoate
CAS 428842-46-0C19H14ClNO4S
(5-Bromo-4-{(Z)-[3-(4-fluorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-2-methoxyphenoxy)acetic acid chemical structure, C20H15BrFNO6S, CAS 364739-30-0
(5-Bromo-4-{(Z)-[3-(4-fluorobenzyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl}-2-methoxyphenoxy)acetic acid
CAS 364739-30-0C20H15BrFNO6S
(5Z)-5-[(4-Ethoxy-3-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C20H18FNO4S, CAS 428847-44-3
(5Z)-5-[(4-Ethoxy-3-methoxyphenyl)methylidene]-3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 428847-44-3C20H18FNO4S