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Murcko scaffold

Ring system with 3 rings and 21 atoms

52 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
52
With full pages
15
Scaffold SMILES

O=C1SC(Nc2ccccc2)C(=O)N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1SC(Nc2ccccc2)C(=O)N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

3-[[5-(4-Methylanilino)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acid chemical structure, C18H16N2O4S, CAS 496019-76-2
3-[[5-(4-Methylanilino)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl]benzoic acid
CAS 496019-76-2C18H16N2O4S
3-[(5-Anilino-2,4-dioxo-1,3-thiazolidin-3-yl)methyl]benzoic acid chemical structure, C17H14N2O4S, CAS 1009238-93-0
3-[(5-Anilino-2,4-dioxo-1,3-thiazolidin-3-yl)methyl]benzoic acid
CAS 1009238-93-0C17H14N2O4S
4-[(3-Benzyl-2,4-dioxo-1,3-thiazolidin-5-yl)amino]benzoic acid chemical structure, C17H14N2O4S, CAS 1008003-23-3
4-[(3-Benzyl-2,4-dioxo-1,3-thiazolidin-5-yl)amino]benzoic acid
CAS 1008003-23-3C17H14N2O4S
3-Benzyl-5-(4-chloroanilino)-1,3-thiazolidine-2,4-dione chemical structure, C16H13ClN2O2S, CAS 473720-96-6
3-Benzyl-5-(4-chloroanilino)-1,3-thiazolidine-2,4-dione
CAS 473720-96-6C16H13ClN2O2S
3-Benzyl-5-(4-methoxyanilino)-1,3-thiazolidine-2,4-dione chemical structure, C17H16N2O3S, CAS 474003-91-3
3-Benzyl-5-(4-methoxyanilino)-1,3-thiazolidine-2,4-dione
CAS 474003-91-3C17H16N2O3S
Methyl 3-({5-[(4-ethoxyphenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoate chemical structure, C20H20N2O5S, CAS 1007926-09-1
Methyl 3-({5-[(4-ethoxyphenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoate
CAS 1007926-09-1C20H20N2O5S
5-(4-Ethoxy-phenylamino)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione chemical structure, C19H20N2O3S, CAS 496019-74-0
5-(4-Ethoxy-phenylamino)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione
CAS 496019-74-0C19H20N2O3S
3-[5-(2-Methoxy-phenylamino)-2,4-dioxo-thiazolidin-3-ylmethyl]-benzoic acid chemical structure, C18H16N2O5S, CAS 496019-80-8
3-[5-(2-Methoxy-phenylamino)-2,4-dioxo-thiazolidin-3-ylmethyl]-benzoic acid
CAS 496019-80-8C18H16N2O5S
3-(4-Methylbenzyl)-5-(4-toluidino)-1,3-thiazolidine-2,4-dione chemical structure, C18H18N2O2S, CAS 496019-71-7
3-(4-Methylbenzyl)-5-(4-toluidino)-1,3-thiazolidine-2,4-dione
CAS 496019-71-7C18H18N2O2S
3-[5-(Carbamoylmethyl-p-tolyl-amino)-2,4-dioxo-thiazolidin-3-ylmethyl]-benzoic acid chemical structure, C20H19N3O5S, CAS 496024-53-4
3-[5-(Carbamoylmethyl-p-tolyl-amino)-2,4-dioxo-thiazolidin-3-ylmethyl]-benzoic acid
CAS 496024-53-4C20H19N3O5S
Methyl 3-({5-[(4-methylphenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoate chemical structure, C19H18N2O4S, CAS 1009232-28-3
Methyl 3-({5-[(4-methylphenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoate
CAS 1009232-28-3C19H18N2O4S
3-({5-[(2-Ethoxy-2-oxoethyl)-4-methylanilino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoic acid chemical structure, C22H22N2O6S, CAS 496024-55-6
3-({5-[(2-Ethoxy-2-oxoethyl)-4-methylanilino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoic acid
CAS 496024-55-6C22H22N2O6S
Ethyl 4-[[3-[(4-methylphenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-yl]amino]benzoate chemical structure, C20H20N2O4S, CAS 496019-75-1
Ethyl 4-[[3-[(4-methylphenyl)methyl]-2,4-dioxo-1,3-thiazolidin-5-yl]amino]benzoate
CAS 496019-75-1C20H20N2O4S
5-(4-Methylanilino)-3-[(4-nitrophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C17H15N3O4S, CAS 1009700-80-4
5-(4-Methylanilino)-3-[(4-nitrophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 1009700-80-4C17H15N3O4S
3-{[3-(3-Carboxybenzyl)-2,4-dioxo-1,3-thiazolidin-5-yl]amino}benzoic acid chemical structure, C18H14N2O6S, CAS 496019-83-1
3-{[3-(3-Carboxybenzyl)-2,4-dioxo-1,3-thiazolidin-5-yl]amino}benzoic acid
CAS 496019-83-1C18H14N2O6S
Methyl 3-({5-[(4-chlorophenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoate chemical structure, C18H15ClN2O4S, CAS 1008003-67-5
Methyl 3-({5-[(4-chlorophenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoate
CAS 1008003-67-5C18H15ClN2O4S
3-{[5-(2,4-Dimethylanilino)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}benzoic acid chemical structure, C19H18N2O4S, CAS 496019-82-0
3-{[5-(2,4-Dimethylanilino)-2,4-dioxo-1,3-thiazolidin-3-yl]methyl}benzoic acid
CAS 496019-82-0C19H18N2O4S
5-(4-Chloroanilino)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione chemical structure, C17H15ClN2O2S, CAS 496019-73-9
5-(4-Chloroanilino)-3-(4-methylbenzyl)-1,3-thiazolidine-2,4-dione
CAS 496019-73-9C17H15ClN2O2S
3-({5-[(2-Amino-2-oxoethyl)(3-methylphenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoic acid chemical structure, C20H19N3O5S, CAS 1008189-08-9
3-({5-[(2-Amino-2-oxoethyl)(3-methylphenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoic acid
CAS 1008189-08-9C20H19N3O5S
5-(3-Methylanilino)-3-[(4-nitrophenyl)methyl]-1,3-thiazolidine-2,4-dione chemical structure, C17H15N3O4S, CAS 1008958-64-2
5-(3-Methylanilino)-3-[(4-nitrophenyl)methyl]-1,3-thiazolidine-2,4-dione
CAS 1008958-64-2C17H15N3O4S
3-{[2,4-Dioxo-5-(2-toluidino)-1,3-thiazolidin-3-yl]methyl}benzoic acid chemical structure, C18H16N2O4S, CAS 496019-77-3
3-{[2,4-Dioxo-5-(2-toluidino)-1,3-thiazolidin-3-yl]methyl}benzoic acid
CAS 496019-77-3C18H16N2O4S
Methyl 3-[(5-{[4-(ethoxycarbonyl)phenyl]amino}-2,4-dioxo-1,3-thiazolidin-3-yl)methyl]benzoate chemical structure, C21H20N2O6S, CAS 1024593-98-3
Methyl 3-[(5-{[4-(ethoxycarbonyl)phenyl]amino}-2,4-dioxo-1,3-thiazolidin-3-yl)methyl]benzoate
CAS 1024593-98-3C21H20N2O6S
3-((3-(4-Nitrobenzyl)-2,4-dioxothiazolidin-5-yl)amino)benzoic acid chemical structure, C17H13N3O6S, CAS 1008010-62-5
3-((3-(4-Nitrobenzyl)-2,4-dioxothiazolidin-5-yl)amino)benzoic acid
CAS 1008010-62-5C17H13N3O6S
3-({5-[(4-Chlorophenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoic acid chemical structure, C17H13ClN2O4S, CAS 496019-79-5
3-({5-[(4-Chlorophenyl)amino]-2,4-dioxo-1,3-thiazolidin-3-yl}methyl)benzoic acid
CAS 496019-79-5C17H13ClN2O4S