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Murcko scaffold

Ring system with 2 rings and 23 atoms

54 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
23
Chemicals
54
With full pages
5
Scaffold SMILES

O=C(CCC(=O)OCC(=O)c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCC(=O)OCC(=O)c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 54 chemicals

2-Oxo-2-phenylethyl 4-(3,4-dichloroanilino)-4-oxobutanoate chemical structure, C18H15Cl2NO4, CAS 311331-14-3
2-Oxo-2-phenylethyl 4-(3,4-dichloroanilino)-4-oxobutanoate
CAS 311331-14-3C18H15Cl2NO4
[2-(4-Bromophenyl)-2-oxoethyl] 4-(4-hydroxyanilino)-4-oxobutanoate chemical structure, C18H16BrNO5, CAS 331269-45-5
[2-(4-Bromophenyl)-2-oxoethyl] 4-(4-hydroxyanilino)-4-oxobutanoate
CAS 331269-45-5C18H16BrNO5
2-(4-Bromophenyl)-2-oxoethyl 4-oxo-4-(3-toluidino)butanoate chemical structure, C19H18BrNO4, CAS 5281-98-1
2-(4-Bromophenyl)-2-oxoethyl 4-oxo-4-(3-toluidino)butanoate
CAS 5281-98-1C19H18BrNO4
2-(4-Bromophenyl)-2-oxoethyl 4-(4-amino-3-bromo-5-chloroanilino)-4-oxobutanoate chemical structure, C18H15Br2ClN2O4, CAS 331269-84-2
2-(4-Bromophenyl)-2-oxoethyl 4-(4-amino-3-bromo-5-chloroanilino)-4-oxobutanoate
CAS 331269-84-2C18H15Br2ClN2O4
2-(4-Bromophenyl)-2-oxoethyl 4-[(2,5-dichlorophenyl)amino]-4-oxobutanoate chemical structure, C18H14BrCl2NO4, CAS 331269-88-6
2-(4-Bromophenyl)-2-oxoethyl 4-[(2,5-dichlorophenyl)amino]-4-oxobutanoate
CAS 331269-88-6C18H14BrCl2NO4
2-(4-Bromophenyl)-2-oxoethyl 4-(2,5-dimethylanilino)-4-oxobutanoate chemical structure, C20H20BrNO4, CAS 331269-83-1
2-(4-Bromophenyl)-2-oxoethyl 4-(2,5-dimethylanilino)-4-oxobutanoate
CAS 331269-83-1C20H20BrNO4
Phenacyl 4-(2,5-dichloroanilino)-4-oxobutanoate chemical structure, C18H15Cl2NO4, CAS 351443-40-8
Phenacyl 4-(2,5-dichloroanilino)-4-oxobutanoate
CAS 351443-40-8C18H15Cl2NO4
Phenacyl 4-(2-chloroanilino)-4-oxobutanoate chemical structure, C18H16ClNO4, CAS 313965-28-5
Phenacyl 4-(2-chloroanilino)-4-oxobutanoate
CAS 313965-28-5C18H16ClNO4
2-Oxo-2-phenylethyl 3-[N-(4-acetylphenyl)carbamoyl]propanoate chemical structure, C20H19NO5, CAS 351994-97-3
2-Oxo-2-phenylethyl 3-[N-(4-acetylphenyl)carbamoyl]propanoate
CAS 351994-97-3C20H19NO5
Methyl 4-({4-[2-(3-nitrophenyl)-2-oxoethoxy]-4-oxobutanoyl}amino)benzoate chemical structure, C20H18N2O8, CAS 352005-30-2
Methyl 4-({4-[2-(3-nitrophenyl)-2-oxoethoxy]-4-oxobutanoyl}amino)benzoate
CAS 352005-30-2C20H18N2O8
[2-(4-Methoxyphenyl)-2-oxoethyl] 4-(2-chloroanilino)-4-oxobutanoate chemical structure, C19H18ClNO5, CAS 351496-86-1
[2-(4-Methoxyphenyl)-2-oxoethyl] 4-(2-chloroanilino)-4-oxobutanoate
CAS 351496-86-1C19H18ClNO5
[2-(4-Methoxyphenyl)-2-oxoethyl] 4-(2-methoxyanilino)-4-oxobutanoate chemical structure, C20H21NO6, CAS 351496-94-1
[2-(4-Methoxyphenyl)-2-oxoethyl] 4-(2-methoxyanilino)-4-oxobutanoate
CAS 351496-94-1C20H21NO6
2-(4-Methoxyphenyl)-2-oxoethyl 4-{3-nitroanilino}-4-oxobutanoate chemical structure, C19H18N2O7, CAS 348115-18-4
2-(4-Methoxyphenyl)-2-oxoethyl 4-{3-nitroanilino}-4-oxobutanoate
CAS 348115-18-4C19H18N2O7
2-(4-Methoxyphenyl)-2-oxoethyl 4-(4-fluoroanilino)-4-oxobutanoate chemical structure, C19H18FNO5, CAS 351497-37-5
2-(4-Methoxyphenyl)-2-oxoethyl 4-(4-fluoroanilino)-4-oxobutanoate
CAS 351497-37-5C19H18FNO5
[2-(4-Chlorophenyl)-2-oxoethyl] 4-(3-hydroxyanilino)-4-oxobutanoate chemical structure, C18H16ClNO5, CAS 351497-44-4
[2-(4-Chlorophenyl)-2-oxoethyl] 4-(3-hydroxyanilino)-4-oxobutanoate
CAS 351497-44-4C18H16ClNO5
2-(4-Bromophenyl)-2-oxoethyl 4-oxo-4-[3-(trifluoromethyl)anilino]butanoate chemical structure, C19H15BrF3NO4, CAS 351497-51-3
2-(4-Bromophenyl)-2-oxoethyl 4-oxo-4-[3-(trifluoromethyl)anilino]butanoate
CAS 351497-51-3C19H15BrF3NO4
2-{3-Nitrophenyl}-2-oxoethyl 4-(2-methoxyanilino)-4-oxobutanoate chemical structure, C19H18N2O7, CAS 329049-10-7
2-{3-Nitrophenyl}-2-oxoethyl 4-(2-methoxyanilino)-4-oxobutanoate
CAS 329049-10-7C19H18N2O7
2-(4-Bromophenyl)-2-oxoethyl 4-(4-ethoxyanilino)-4-oxobutanoate chemical structure, C20H20BrNO5, CAS 348116-78-9
2-(4-Bromophenyl)-2-oxoethyl 4-(4-ethoxyanilino)-4-oxobutanoate
CAS 348116-78-9C20H20BrNO5
2-{3-Nitrophenyl}-2-oxoethyl 4-(3-chloroanilino)-4-oxobutanoate chemical structure, C18H15ClN2O6, CAS 351497-47-7
2-{3-Nitrophenyl}-2-oxoethyl 4-(3-chloroanilino)-4-oxobutanoate
CAS 351497-47-7C18H15ClN2O6
2-{4-Nitrophenyl}-2-oxoethyl 4-(2-chloroanilino)-4-oxobutanoate chemical structure, C18H15ClN2O6, CAS 351497-49-9
2-{4-Nitrophenyl}-2-oxoethyl 4-(2-chloroanilino)-4-oxobutanoate
CAS 351497-49-9C18H15ClN2O6
2-{4-Nitrophenyl}-2-oxoethyl 4-oxo-4-[3-(trifluoromethyl)anilino]butanoate chemical structure, C19H15F3N2O6, CAS 329049-11-8
2-{4-Nitrophenyl}-2-oxoethyl 4-oxo-4-[3-(trifluoromethyl)anilino]butanoate
CAS 329049-11-8C19H15F3N2O6
2-(4-Bromophenyl)-2-oxoethyl 4-anilino-4-oxobutanoate chemical structure, C18H16BrNO4, CAS 331269-44-4
2-(4-Bromophenyl)-2-oxoethyl 4-anilino-4-oxobutanoate
CAS 331269-44-4C18H16BrNO4
2-(4-Bromophenyl)-2-oxoethyl 4-(4-bromoanilino)-4-oxobutanoate chemical structure, C18H15Br2NO4, CAS 331269-53-5
2-(4-Bromophenyl)-2-oxoethyl 4-(4-bromoanilino)-4-oxobutanoate
CAS 331269-53-5C18H15Br2NO4
2-(4-Bromophenyl)-2-oxoethyl 4-oxo-4-(2-toluidino)butanoate chemical structure, C19H18BrNO4, CAS 331269-43-3
2-(4-Bromophenyl)-2-oxoethyl 4-oxo-4-(2-toluidino)butanoate
CAS 331269-43-3C19H18BrNO4